Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chris J, Weston"'
Autor:
Gideon M. Hirschfield, Katherine Arndtz, Amanda Kirkham, Yung-Yi Chen, Richard Fox, Anna Rowe, Jessica Douglas-Pugh, Douglas Thorburn, Eleanor Barnes, Guruprasad P. Aithal, Diana Hull, Khushpreet Bhandal, Kathryn Olsen, Paul Woodward, Siân Lax, Philip Newsome, David J. Smith, Antero Kallio, David H. Adams, Victoria Homer, Chris J. Weston
Publikováno v:
Hepatology Communications, Vol 8, Iss 5 (2024)
Background:. Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We evaluated the
Externí odkaz:
https://doaj.org/article/1b222fe6ac3c4e409c92ca04f98f474a
Autor:
Caitlin Hall, Jonathan P. Law, Jasmeet S. Reyat, Max J. Cumberland, Shaun Hang, Nguyen T. N. Vo, Kavita Raniga, Chris J. Weston, Christopher O’Shea, Jonathan N. Townend, Katja Gehmlich, Charles J. Ferro, Chris Denning, Davor Pavlovic
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are characterised by increased α-smooth muscle actin (
Externí odkaz:
https://doaj.org/article/0120de0a24174c8798d8cc3427fd584c
Autor:
Juma El-Awaisi, Dean P.J. Kavanagh, Marco R. Rink, Chris J. Weston, Nigel E. Drury, Neena Kalia
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Following myocardial infarction (MI), elderly patients have a poorer prognosis than younger patients, which may be linked to increased coronary microvessel susceptibility to injury. Interleukin-36 (IL-36), a newly discovered proinflammatory member of
Externí odkaz:
https://doaj.org/article/ce0d8a51a5314581bed63a00d79bb977
Autor:
Yung-Yi Chen, Kathryn Arndtz, Gwilym Webb, Margaret Corrigan, Sarah Akiror, Evaggelia Liaskou, Paul Woodward, David H. Adams, Chris J. Weston, Gideon M. Hirschfield
Publikováno v:
JHEP Reports, Vol 1, Iss 5, Pp 369-376 (2019)
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive inflammatory and fibrotic injury to the biliary tree. We sought to further delineate the contribution of macrophage lineages i
Externí odkaz:
https://doaj.org/article/f2463d17726849958175a35e455840f2
Autor:
Wafa, Khamri, Cathrin, Gudd, Tong, Liu, Rooshi, Nathwani, Marigona, Krasniqi, Sofia, Azam, Thomas, Barbera, Francesca M, Trovato, Lucia, Possamai, Evangelos, Triantafyllou, Rocio Castro, Seoane, Fanny, Lebosse, Arjuna, Singanayagam, Naveenta, Kumar, Christine, Bernsmeier, Sujit, Mukherjee, Mark, McPhail, Chris J, Weston, Charalambos Gustav, Antoniades, Mark R, Thursz
Publikováno v:
Gut. 71(6)
Identifying components of immuneparesis, a hallmark of chronic liver failure, is crucial for our understanding of complications in cirrhosis. Various suppressor CD4Flow cytometry was used to determine the proportion and immunophenotype of CD4Patients
Autor:
Christophe, Fromont, Alessio, Atzori, Divneet, Kaur, Lubna, Hashmi, Graziella, Greco, Alejandro, Cabanillas, Huy Van, Nguyen, D Heulyn, Jones, Miguel, Garzón, Ana, Varela, Brett, Stevenson, Greg P, Iacobini, Marc, Lenoir, Sundaresan, Rajesh, Clare, Box, Jitendra, Kumar, Paige, Grant, Vera, Novitskaya, Juliet, Morgan, Fiona J, Sorrell, Clara, Redondo, Andreas, Kramer, C John, Harris, Brendan, Leighton, Steven P, Vickers, Sharon C, Cheetham, Colin, Kenyon, Anna M, Grabowska, Michael, Overduin, Fedor, Berditchevski, Chris J, Weston, Stefan, Knapp, Peter M, Fischer, Sam, Butterworth
Publikováno v:
Journal of Medicinal Chemistry
Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr
Autor:
Daniel A. Patten, Sivesh K. Kamarajah, Joanne M. Rose, Joseph Tickle, Emma L. Shepherd, David H. Adams, Chris J. Weston, Shishir Shetty
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Liver-resident cells are constantly exposed to gut-derived antigens via portal blood and, as a consequence, they express a unique repertoire of scavenger receptors. Whilst there is increasing evidence that the gut contributes to chronic inflammatory
Publikováno v:
Journal of Hepatology. 73:S525
Autor:
Evangelos, Triantafyllou, Oltin T, Pop, Lucia A, Possamai, Annika, Wilhelm, Evaggelia, Liaskou, Arjuna, Singanayagam, Christine, Bernsmeier, Wafa, Khamri, Gemma, Petts, Rebecca, Dargue, Scott P, Davies, Joseph, Tickle, Muhammed, Yuksel, Vishal C, Patel, Robin D, Abeles, Zania, Stamataki, Stuart M, Curbishley, Yun, Ma, Ian D, Wilson, Muireann, Coen, Kevin J, Woollard, Alberto, Quaglia, Julia, Wendon, Mark R, Thursz, David H, Adams, Chris J, Weston, Charalambos G, Antoniades
Publikováno v:
Gut
OBJECTIVE: Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms underlying resolution of acute hepatic inflammation are largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0aabdd9205cb86ecb69f5be231eb05e9
Autor:
Palak J, Trivedi, Joseph, Tickle, Mette Nåmdal, Vesterhus, Peter J, Eddowes, Tony, Bruns, Jani, Vainio, Richard, Parker, David, Smith, Evaggelia, Liaskou, Liv Wenche, Thorbjørnsen, Gideon M, Hirschfield, Kaisa, Auvinen, Stefan G, Hubscher, Marko, Salmi, David H, Adams, Chris J, Weston
Publikováno v:
Gut
Objective Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of IBD. This clinical association is linked pathologically to the recruitment of mucosal T cells to the liver, via vascular adhesion protein (VAP)-1-dependent