Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Chris Hillier"'
Publikováno v:
Leukemia Research. 33:1440-1447
Tumor cell demise is an important event in the elimination of abnormal malignant cells and provides an important mechanism of natural tumor suppression. Abnormalities incapacitating these finely tuned processes provide a strong advantage for cancer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a830bb307d0df01992f4827e06ea53e
https://doi.org/10.1016/j.leukres.2009.05.025
https://doi.org/10.1016/j.leukres.2009.05.025
Publikováno v:
Equine Veterinary Journal. 40:488-492
Summary Reasons for performing study: Endothelin-1 (ET-1) may be a key mediator in the pathogenesis of laminitis, but endothelin-mediated responses in the venous microcirculation of the equine foot have yet to be fully characterised. Objectives: To c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5643600c2c27f60b208bb2e508a1c84
https://doi.org/10.2746/042516408x313634
https://doi.org/10.2746/042516408x313634
Autor:
Merete T. Wiiger, Mohammad Amarzguioui, Michael A. Collingwood, Chris Hillier, John J. Rossi, Mark A. Behlke, Lingyan Huang, Harris S. Soifer, Scott D. Rose
Publikováno v:
Oligonucleotides. 18:187-200
Dicer-substrate small interfering RNAs (DsiRNAs) are synthetic RNA duplexes that are processed by Dicer into 21-mer species and show improved potency as triggers of RNA interference, particularly when used at low dose. Chemical modification patterns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61404f3e7fae0c184de41ca2d1b2237
https://doi.org/10.1089/oli.2008.0123
https://doi.org/10.1089/oli.2008.0123
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 57:92-99
Introduction Pharmacological evaluation of the unique equine laminar microvasculature is crucial to understanding its role in health and in diseases such as laminitis. However, separating the distinctive characteristics of arterial versus venous comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fc9df69d0ce23f475aae58b590c47f
https://doi.org/10.1016/j.vascn.2007.10.005
https://doi.org/10.1016/j.vascn.2007.10.005
Autor:
Christopher Sainsbury, Chris Hillier, John R. Petrie, J Coleman, J. M. C. Connell, Adrian J. B. Brady
Publikováno v:
Journal of Human Hypertension. 21:808-814
In human essential hypertension (EH), endothelium-dependent relaxation can occur independent of nitric oxide (NO) and prostacyclin (PGI(2)). Recent in vivo data suggest that rapid compensatory upregulation of endothelial cytochrome P450 epoxygenase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18862771c2d96b3757b8b619fbc3c643
https://doi.org/10.1038/sj.jhh.1002226
https://doi.org/10.1038/sj.jhh.1002226
Publikováno v:
European Journal of Pharmacology. 503:155-163
Arteries were isolated from male DBA/2 mice and mounted on a small vessel wire myograph for isometric recording. Responses to exogenous noradrenaline were inhibited with high affinity by prazosin (pKB, 9.3) and 5-methyl-urapidil (pKB, 9.2) and with l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597b4fc17ae8836c2dc4728152269103
https://doi.org/10.1016/j.ejphar.2004.09.046
https://doi.org/10.1016/j.ejphar.2004.09.046
Publikováno v:
Pharmacology & Therapeutics. 103:179-201
Adrenomedullin (AM) is a peptide that possesses potentially beneficial properties. Since the initial discovery of the peptide by Kitamura et al. in 1993, the literature has been awash with reports describing its novel mechanisms of action and huge po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8632a698be8f4a2718808666b0b85b54
https://doi.org/10.1016/j.pharmthera.2004.07.002
https://doi.org/10.1016/j.pharmthera.2004.07.002
Publikováno v:
Experimental Physiology. 88:547-554
Resistance arteries isolated from patients with critical limb ischaemia (CLI), a hypotensive/hypoperfusion state of the lower leg, have been shown to undergo morphological changes opposite to those observed in hypertension, that is, decreased wall th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f3df1380863bde70ffe8eeacea2111
https://doi.org/10.1113/eph8802552
https://doi.org/10.1113/eph8802552
Publikováno v:
Cardiovascular Research. 57:554-562
We recently reported the hyper-responsiveness of human skeletal muscle resistance arteries (SkMRAs) to noradrenaline in critical limb ischaemia (CLI). In this study we investigated the characteristics of alpha(1)-adrenoceptor subtypes and evaluated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27028a7287b2fe6ced0b1c139aabcf23
https://doi.org/10.1016/s0008-6363(02)00669-7
https://doi.org/10.1016/s0008-6363(02)00669-7
Autor:
John R. Petrie, Chris Hillier, J. M. C. Connell, Mary Ann Lumsden, Mahesh Perera, Naveed Sattar, Michael Small
Publikováno v:
Human Reproduction. 17:497-502
BACKGROUND: Diabetes is a major risk factor for coronary heart disease in women and event rates increase substantially after the menopause. Observational studies have suggested that estrogens may provide cardioprotection by regulating endothelial nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa93518dc7c6db20aad42919235807bb
https://doi.org/10.1093/humrep/17.2.497
https://doi.org/10.1093/humrep/17.2.497