Zobrazeno 1 - 10 of 519 pro vyhledávání: '"Chris H, Senanayake"'
5
Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir
Autor: Sarabindu Roy, Ajay Yadaw, Subho Roy, Gopal Sirasani, Aravind Gangu, Jack D. Brown, Joseph D. Armstrong, Rodger W. Stringham, B. Frank Gupton, Chris H. Senanayake, David R. Snead
Publikováno v: Organic Process Research & Development
Pyrrolo[2,1-f][1,2,4]triazine (1) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound 1 was produced through a newly developed synthetic methodology utilizing simple building blocks such as pyrrol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983e136e84bfddd6c883973d853a5823
http://europepmc.org/articles/PMC8787819
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6
Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine
Autor: Ajay Yadaw, Saeed Ahmad, Grace P. Ahlqvist, Joseph D. Armstrong, Sarabindu Roy, Chris H. Senanayake, Catherine P. McGeough, Timothy F. Jamison, David R. Snead
Publikováno v: ACS Omega, Vol 6, Iss 15, Pp 10396-10402 (2021)
ACS Omega
Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d446c4710171dfaacbbff36a29d09d35
https://doi.org/10.1021/acsomega.1c00772
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7
A Noncoordinating Acid–Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols
Autor: Suttipol Radomkit, Daniel R. Fandrick, Stefan Braith, Chris H. Senanayake, Arindom Chatterjee, Keith R. Fandrick, Carl A. Busacca, Nitinchandra D. Patel
Publikováno v: The Journal of Organic Chemistry. 86:4877-4882
A mild and nonreversible tert-butylation of alcohols and phenols can be achieved in high yields using the noncoordinating acid–base catalyst [bis(trifluoromethane)sulfonimide and 2,6-lutidine] with...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d01f15e7e61ea756fd23e50d5102485
https://doi.org/10.1021/acs.joc.1c00193
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8
Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene
Autor: Xiao-Jun Wang, Lifen Wu, Guisheng Li, Scott Pennino, Bo Qu, Heewon Lee, Xiaowen Hou, Anjan Saha, Jinhua J. Song, Xingzhong Zeng, Chris H. Senanayake, Nizar Haddad, Jon C. Lorenz
Publikováno v: Organic Process Research & Development. 25:583-590
The development of multikilogram scale green and economical synthetic route of enantiomerically pure cis-4-amino-3-fluoro-1-methylpiperidine 1 is described. The synthesis features a highly regio-, ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::650146305739e8743b8a842da574ba06
https://doi.org/10.1021/acs.oprd.0c00525
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9
Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More—Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420
Autor: Heewon Lee, Nelu Grinberg, Nitinchandra D. Patel, Andrew Ye, Azad Hossain, Carl A. Busacca, Jon C. Lorenz, Chris H. Senanayake, Anjan Saha, Denis Byrne, Nizar Haddad, Suresh R. Kapadia, Xudong Wei, Nathan K. Yee, Philomen DeCroos, Bikshandarkoil A. Narayanan, Max Sarvestani, Scott Pennino
Publikováno v: The Journal of Organic Chemistry. 85:8339-8351
An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive SNAr reaction of 4-quinolinyl sulfones with a range of structurally diversified 1°, 2°, and 3° alcohols with a wide substrate scope and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa509fb05026c473613a347b4e4659f
https://doi.org/10.1021/acs.joc.0c00554
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10
Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides
Autor: Nathan K. Yee, Jinghua J. Song, Chris H. Senanayake, Soumik Biswas, Nizar Haddad, Younggi Choi, Bo Qu, Jean-Nicolas Desrosiers
Publikováno v: The Journal of Organic Chemistry. 85:8214-8220
5-Cyanoimidazole was identified as an inexpensive ligand for nickel-catalyzed cross-electrophile couplings by screening a diverse set of pharmaceutical compound library. A strategic screening approach led to the discovery of this novel ligand, which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793a899aea74f72643a669e888e1309f
https://doi.org/10.1021/acs.joc.0c00549
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