Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype

Autor: Axel Stoit, Sjoerd van Schaik, Josephus H. M. Lange, Annemieke Rensink, Adri van den Hoogenband, Chris G. Kruse, Hein K. A. C. Coolen, Arnold P. den Hartog

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:459-465

The synthesis and SAR of a novel class of spirobenzofuranpiperidinyl-derived alkanoic acids 6-34 as sphingosine S1P5 receptor agonists are described. The target compounds generally elicit high S1P5 receptor agonistic potencies and in general are sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd3ebf6ed30fa1e94992ef7801db2807
https://doi.org/10.1016/j.bmcl.2017.12.018

Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex

Autor: Wytse J. Wadman, Tania Vitalis, Pascal Chameau, Qiluan Schaafsma-Zhao, Chris G. Kruse, Kas Houthuijs, Taco R. Werkman, Femke S. den Boon

Publikováno v: Plügers Archiv, 467(7), 1551-1564. Springer Verlag

Activation of the endocannabinoid (eCB) system by exogenous cannabinoids (drug abuse) can alter the physiology of the brain circuits involved in higher-order cognitive functions such as the medial prefrontal cortex (mPFC). A proper balance between ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201c4e65cd4c4e45806f8a6162ab97aa
https://hdl.handle.net/11245/1.447959

Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats

Autor: Clementina M. van Rijn, Chris G. Kruse, Natasja de Bruin, Liesbeth Heijink, Gilles van Luijtelaar, Lyudmila V. Vinogradova, Annika Lüttjohann, Martin F.J. Perescis

Publikováno v: PLoS ONE
PLoS One, 12, 2
PLoS One, 12
PLoS ONE, Vol 12, Iss 2, p e0165363 (2017)

Contains fulltext : 166569.pdf (Publisher’s version ) (Open Access) Cannabinoid CB1 antagonists have been investigated for possible treatment of e.g. obesity-related disorders. However, clinical application was halted due to their symptoms of anxie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099f07915680462082524eaf2382ab95
http://publikationen.ub.uni-frankfurt.de/files/42890/container.zip

19th biennial IPEG Meeting

Autor: Sonja Simpraga, Rosanna Tortelli, Jill C. Richardson, Bernhard Mueller, Berrie J.L. Gerrits, Marieke Jepma, Silvia Armenise, Martin F.J. Perescis, Inga Griskova-Bulanova, C. Wintmolders, Haitham S. Mohammed, J. Leon Kenemans, Matteo Demuru, Paolo Ranzi, Jakub Korcak, J. A. Kemp, Georg Gruber, T. A. Iseger, N. Marzano, Giuseppe Bertini, Caitlyn Kruiper, Anke Sambeth, Ronald J. Swatzyna, Iris Schutte, Robert A. Comley, Frans C. T. van der Helm, Juergen Dukart, Robin L. Carhart-Harris, Flavio Nobili, Martin Brunovsky, Maria Vasileva, José Carlos Millán-Calenti, Kelly Holt, Jan A. Freund, S. Deepeshwar, Alexandra Kirsten, Yasser A. Khadrawy, Daniel Brandeis, Martin Bareš, Roshan Cools, Eduardo Ekman Schenberg, Sigita Melynyte, Antonio Ivano Triggiani, Ashley Baddeley, Karlijn I. van Aerde, Gerhard Trube, Leonardo Jose Trejo, Stephane Nave, D. A. Jackson, Tomáš Páleníček, Raffaella Franciotti, A. E. Maqueda, Laura Bonanni, E. Saifutdinova, Rahul Chaudhary, Natasja de Bruin, Christoph Mulert, Gilles van Luijtelaar, Hans-Christian Pape, Jeannette Hofmeijer, Martin Brunovský, Marijtje L.A. Jongsma, L. Raeymaekers, Boris Ferger, Donna Palmer, Robert Aidelbaum, Nash N. Boutros, Hanneke E. M. den Ouden, Genevieve N. Izzo, Jessica I. Määttä, Lucilla Parnetti, Gerald P. Kozlowski, Arjan Hillebrand, C. Bouyssières, Philip L.C. van den Broek, David J. Nutt, Jay D. Tarnow, Vlastimil Koudelka, Paolo Maria Rossini, Anna-Lena Dohrmann, Peter Veselcic, Asbjørn Mohr Drewes, Antonio Giannini, Ole Jensen, Christiane M. Thiel, Grazia Buenza, Tomas Novak, Chris G. Kruse, Alexander Sumich, Gaetano Scianatico, Jan-Mathijs Schoffelen, V. Duveau, K. Tahon, Lana Donse, Vladimir Krajca, Pierre Payoux, Vaclava Sedlamyerova, Else A. Tolner, M. Arns, Jennifer Mollon, Michael Derks, Nazimah Hamid, Andrea Szabo, Loreto Gesualdo, Shelly M. Menolascino, M. A. Mañanas, Thorsten Mikoteit, D. Balschun, Mitchell Belgin, Giacomo Tattoli, Cestmir Vejmola, Bob Oranje, Barbora Kohutova, Giovanni B. Frisoni, Iris E. C. Sommer, Dylan Smith, Rosa van Mourik, Michel D. Ferrari, Christian Zöllner, Maria-Clemancia Hernandez, Nick Seneca, James Miller, Martijn Arns, Timothy K. Murphy, Giancarlo Logroscino, Annika Lüttjohann, Noreen Rahmani, Christopher Timmermann, Martien J H Kas, Grace Y. Wang, Klaus Linkenkaer-Hansen, F. Nobili, Tieme W. P. Janssen, R. Biermans, Fernando H. Lopes da Silva, Bernd Saletu, Brian A. Coffman, Ileana L. Hanganu-Opatz, Sian Lennon-Chrimes, Madelon A. Vollebregt, D. Moechars, Brittany Duncan, Joerg F. Hipp, Y. Roche, Valentina Cardinali, Neveen A. Noor, Christoph Wandel, S. Romero, Anna Bravermanová, J. Koprivova, Gerda M. Saletu-Zyhlarz, Nicola Walter Falasca, Marco Onofrj, Jaap Oosterlaan, J. L. Kenemans, J. Prasko, Jürgen Gallinat, C. Roucard, Vaclava Piorecka, Karsten Wicke, Jennifer C. Swart, Peterjan Ris, Heba S. Aboul Ezz, M Valle, Jesper F. Bastlund, Ivo Heitland, Paul B. Fitzgerald, Katleen Geladé, W. H. Drinkenburg, Lillian E. Fisher, Lars Eichler, J. Riba, Hélène Brisebois, Régis Bordet, Robert Leech, Roberta Lizio, Cornelis J. Stam, M. Avinash, N. K. Manjunath, Parissa Azadi, Raffaele Ferri, Cyril Höschl, Susanna Cordone, Sander Nieuwenhuis, Gregor Leicht, Alexandra J. Roark, Esben Bolvig Mark, Jakub Polak, Alexander T. Sack, Iris Eichler, Heidi Haavik, Athanasios Maras, Dirk J. Heslenfeld, Hans-Peter Landolt, A. Bottelbergs, Galina Surova, Ross Apparies, Lin Tiffany, Angelisa Frasca, Ida A. Nissen, Dario Arnaldi, Alessandro Bertolino, Wilhelmus Drinkenburg, Philip Scheltens, Cristina Bagnoli, Matthijs J.L. Perenboom, Dane M. Chetkovich, Thomas Budde, Annette Beatrix Brühl, Wilfried Dimpfel, Yuan Yang, Jonathan Kelley, Hervé Caci, Christoph Herrmann, Olivier Blin, Robert P. Turner, Georg Dorffner, Michaela Viktorinova, Igor Timofeev, Stephanie Thiebes, Dina Lelic, K. Van Kolen, P. F. Fabene, Frédéric Knoflach, S. Jacob, John Wallerius, Claudio Del Percio, Marina Bentivoglio, Mendel Kaelen, Peter Anderer, Imran Khan Niazi, Iman M. Mourad, S. Barker, Muhammad Samran Navid, Giuseppe Noce, Dean F. Salisbury, Huibert D. Mansvelder, Premysl Vlcek, Marek Adamczyk, Emmanouil Spanakis, Vitoantonio Bevilacqua, Orietta Barulli, Roy P. C. Kessels, Axel Steiger, Darren Bentley, Antonio Brunetti, Clementina M. van Rijn, Nikita van der Vinne, Evian Gordon, Nash Boutros, Lukáš Kadeřábek, Brendan Parsons, A. Ahnaou, Tilman Hensch, Christian Sander, Torsten Meyer, Barbora Cimrová, Marleen C. Tjepkema-Cloostermans, Molly Hyde, Robert Oostenveld, Liesbeth Heijink, Eléonore Czarik, Paolo F. Fabene, Jean-Paul Laurent, Stig Hollup, Leon Kenemans, Ana Buján, Vadim Ilivitsky, Danielle Impey, Alfred C. Schouten, Claudio Babiloni, M. Pawlowski, Ricardo Alvarez-Jimenez, Joop M. A. van Gerven, Filip Tylš, Jan van Egmond, Saskia Steinmann, Caroline Dupont, B. Mandé-Nidergang, Sebastian Olbrich, Geert Jan Groeneveld, H. Huysmans, Kastytis Dapsys, P. Sos, M. Raszka, C. Walsh, Justin Piché, Giovanni Frisoni, Silvia Parapatics, Annika Lütjohann, Simon-Shlomo Poil, Erin K. MacInerney, T. Nekovarova, Jana Nöldeke, Michel J.A.M. van Putten, Ilse E. C. W. van Straaten, Suresh D. Muthukumaraswamy, Mehrnoush Zobeiri, Magda Tsolaki, Ulrich Hegerl, Jaap C. Reijneveld, Patrizia Voehringer, N. V. Manyakov, Sandra K. Loo, Patrick Meuth, Bettina Clausen, Roman Rosipal, David Bartrés Faz, Nenad Polomac, Renata Androvicova, Pantaleo Spagnolo, Pilar Garcés, Andrea Soricelli, Amanda Feilding, R. Maury, Aleksandras Voicikas, Stjepan Curic, Verner Knott, Tabitha A. Iseger, Jiri Horacek, Susanna Lopez, Joelle Choueiry, Gianluigi Forloni, Andrew WThomas, Lyudmila V. Vinogradova, Alida A. Gouw, Sarah M. Haigh, B. Pouyatos

Publikováno v: Neuropsychiatric Electrophysiology. 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b3645dd372ee3dc7a51d9db9303cdbd
https://doi.org/10.1186/s40810-016-0021-4

NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig

Autor: Taco R. Werkman, Wytse J. Wadman, Andrew C. McCreary, Chris G. Kruse

Publikováno v: Synapse, 65(8), 814-826. Wiley-Liss Inc.

This in vitro study investigates and compares the effects of NK3 receptor ligands on the firing rate of rat and guinea pig midbrain dopamine neurons. The findings are discussed in the light of choosing suitable animal models for investigating pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798d56d69623ee212f0706123f82e330
https://doi.org/10.1002/syn.20908