Descriptive epidemiology and phylogenetic analysis of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada, September 2022 to June 2023

Autor: Shannon L. Russell, Cassandra L. Andrew, Kevin C. Yang, Michelle Coombe, Glenna McGregor, Tony Redford, Agatha N. Jassem, James E. A. Zlosnik, Jolene Giacinti, Kevin S. Kuchinski, John L. Palmer, John R. Tyson, Chris Fjell, Megan Willie, Megan V. Ross, Maeve Winchester, Laurie Wilson, Yohannes Berhane, Caeley Thacker, N. Jane Harms, Catherine Soos, Theresa Burns, Natalie Prystajecky, Chelsea Himsworth

Publikováno v: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Surveillance data from wildlife and poultry was used to describe the spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in British Columbia (B.C.) and the Yukon, Canada from September 2022 – June 2023 compared to the first “wa

Externí odkaz: https://doaj.org/article/386e01dba7274cdf9e27fb84d7eea79c

Rapid Increase in SARS-CoV-2 P.1 Lineage Leading to Codominance with B.1.1.7 Lineage, British Columbia, Canada, January–April 2021

Autor: Catherine A. Hogan, Agatha N. Jassem, Hind Sbihi, Yayuk Joffres, John R. Tyson, Kyle Noftall, Marsha Taylor, Tracy Lee, Chris Fjell, Amanda Wilmer, John Galbraith, Marc G. Romney, Bonnie Henry, Mel Krajden, Eleni Galanis, Natalie Prystajecky, Linda M.N. Hoang

Publikováno v: Emerging Infectious Diseases, Vol 27, Iss 11, Pp 2802-2809 (2021)

Several severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) emerged in late 2020; lineage B.1.1.7 initially dominated globally. However, lineages B.1.351 and P.1 represent potentially greater risk for transmission and immune es

Externí odkaz: https://doaj.org/article/54cec6baaa024ce1a8ea5daafb6c843f

DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis

Autor: Sahil Gupta, Hajera Amatullah, James N. Tsoporis, Kuiru Wei, Ana Paula Teixeira Monteiro, Amin M. Ektesabi, Amir K. Varkouhi, Chirag M. Vaswani, Amanda Formosa, Alexandre T. Fabro, Sri Nagarjun Batchu, Chris Fjell, James A. Russell, Keith R. Walley, Andrew Advani, Thomas G. Parker, John C. Marshall, Patricia R. M. Rocco, Gregory D. Fairn, Tak Wah Mak, Claudia C. dos Santos

Publikováno v: Cell Death & Differentiation. 29:2024-2033

The ability to effectively clear infection is fundamental to host survival. Sepsis, defined as dysregulated host response to infection, is a heterogenous clinical syndrome that does not uniformly clear intact bacterial or sterile infection (i.e., lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0ffe6c7edb91e1827bdc2f23575e12
https://doi.org/10.1038/s41418-022-00993-2

Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients

Autor: Alex K. K. Leung, Elena Topchiy, James A. Russell, Kelly R. Genga, Chris Fjell, Mihai Cirstea, Keith R. Walley, John H. Boyd, Tadanaga Shimada

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)

Previous studies have shown lipopolysaccharide from Gram-negative bacteria is cleared from the circulation via LDL receptors on hepatocytes, which are downregulated by PCSK9. Whether clearance of Gram positive bacterial lipoteichoic acid (LTA) shows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ddf0a67254428ded5dbe2b93a7aa67
https://doi.org/10.1038/s41598-019-46745-0

Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients

Autor: Helen M. Ryan, Peter von Dadelszen, Chris Fjell, Laura A. Magee, Alice B R Aarvold, Keith R. Walley

Publikováno v: Aarvold, A B R, Ryan, H M, Magee, L A, Von Dadelszen, P, Fjell, C & Walley, K R 2017, ' Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients ', Critical Care Medicine, vol. 45, no. 1, pp. e49-e57 . https://doi.org/10.1097/CCM.0000000000002018
Critical Care Medicine

Objectives: Mortality prediction scores have been used for a long time in ICUs; however, numerous studies have shown that they over-predict mortality in the obstetric population. With sepsis remaining a major cause of obstetric mortality, we aimed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f3a2be46614b064d888611f5295e69
https://kclpure.kcl.ac.uk/ws/files/85566821/Multiple_Organ_Dysfunction_Score_AARVOLD_Published_GOLD_VoR_CC_BY_NC_ND_.pdf