Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Chris Ebeling"'
Autor:
Todd Juan, Murielle M. Véniant, Joan Helmering, Philip Babij, Daniel M. Baker, Michael A. Damore, Michael B. Bass, Tibor Gyuris, Mark Chhoa, Chi-Ming Li, Chris Ebeling, Julie Amato, George A. Carlson, David J. Lloyd
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 534-545 (2009)
We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice. We screened 7,546 G3 mice that were of mixed C57BL/6J (B6)×C3.SW-H2b/SnJ (C3) genomes and i
Externí odkaz:
https://doaj.org/article/c01f6f3ea8d54e55b1a419cd8a290684
Autor:
Daniel M. Baker, George A. Carlson, Murielle M. Véniant, Mark Chhoa, Julie Amato, Michael Bass, Chi-Ming Li, Philip Babij, Michael A. Damore, Joan Helmering, Chris Ebeling, David Lloyd, Tibor Gyuris, Todd Juan
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 534-545 (2009)
We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice. We screened 7,546 G3 mice that were of mixed C57BL/6J (B6) x C3.SW-H2(b)/SnJ (C3) genomes an
Autor:
Heather Pelly, Patrick Horne, Stephen D. Schmidt, George A. Carlson, Janaky Coomaraswamy, David Westaway, Georges Lévesque, Peter St George-Hyslop, Bob Strome, Matthew J. Mazzella, Paul M. Mathews, Ying Jiang, Paul E. Fraser, Peter Mastrangelo, Ralph A. Nixon, M. Azhar Chishti, Chris Ebeling, Richard Rozmahel, Yongjun Gu, Jing Yang
Publikováno v:
Proceedings of the National Academy of Sciences. 102:8972-8977
γ-secretase depends on presence of presenilins (PS), Nct, Aph-1, and PEN-2 within a core complex. This endoproteolytic activity cleaves within transmembrane domains of amyloid-β precursor protein (APP) and Notch, and familial Alzheimer's disease (F
Autor:
Pei Shu, Chris Ebeling, George A. Carlson, John S. Smutko, Paul D. Markel, Karen J. Moore, Deborah L. Nagle
Publikováno v:
Nature Genetics. 17:280-284
Congenic breeding strategies are becoming increasingly important as a greater number of complex trait linkages are identified. Traditionally, the development of a congenic strain has been a time-consuming endeavour, requiring ten generations of backc
Autor:
Chris Ebeling, Elizabeth A. Woolf, Dennis Huszar, Deborah L. Nagle, Sonja H. McGrail, Karen J. Moore, Barry J. Dussault, Paul Burn, Victoria Fairchild-Huntress, George A. Carlson, Peer Bork, Lisa DiRocco, Pei Ge, Jill Montagno, James Vitale, Lisa Holmgren, Linda Baldini, Julie Gilchrist, John Keilty
Publikováno v:
Nature. 398(6723)
Genetic studies have shown that mutations within the mahogany locus suppress the pleiotropic phenotypes, including obesity, of the agouti-lethal-yellow mutant. Here we identify the mahogany gene and its product; this study, to our knowledge, represen
Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family
Autor:
Ye Wu, Nathan D Lakey, Thomas Brody, Karen J. Moore, Janice A. Culpepper, George A. Carlson, Lisa Holmgren, Geoffrey D Alperin, John Lee, Patrick W. Kleyn, Jim Deeds, Elizabeth A. Woolf, Don J Misumi, Lucy R Berkemeier, Olga Tayber, Chris Ebeling, Linda Baldini, Olga Charlat, Jacqueline C. Pulido, Pei Shu, M.Alexandra Glücksmann-Kuis, Geoffrey M. Duyk, Steve G. Kovats, Brenda Kennedy, Fiona Hawkins, Hong Chen, Wei Fan
Publikováno v:
Cell. (2):281-290
The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The conse
Conference
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