Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chris E. Pollard"'
Autor:
Jean-Pierre Valentin, Hitesh Mistry, Najah Abi-Gerges, Chris E. Pollard, L. Hussein, Jonathan Swinton, Mark R. Davies
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H1466-H1480
Cell lines expressing ion channels (IC) and the advent of plate-based electrophysiology device have enabled a molecular understanding of the action potential (AP) as a means of early QT assessment. We sought to develop an in silico AP (isAP) model th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e538f9a49efe02bc7c2984744e08f713
https://doi.org/10.1152/ajpheart.00808.2011
https://doi.org/10.1152/ajpheart.00808.2011
Autor:
Gail A. Robertson, H. Holkham, Eugenia M.C. Jones, J-P Valentin, Chris E. Pollard, Najah Abi-Gerges
Publikováno v:
British Journal of Pharmacology. 164:419-432
BACKGROUND AND PURPOSE The majority of human ether-a-go-go-related gene (hERG) screens aiming to minimize the risk of drug-induced long QT syndrome have been conducted using heterologous systems expressing the hERG 1a subunit, although both hERG 1a a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e97cd94cb1a04634dfdd0f13050def
https://doi.org/10.1111/j.1476-5381.2011.01378.x
https://doi.org/10.1111/j.1476-5381.2011.01378.x
Publikováno v:
British Journal of Pharmacology. 159:77-92
Background and purpose: Evaluation of the potential for delayed ventricular repolarization and proarrhythmia by new drugs is essential. We investigated if dog left ventricular midmyocardial myocytes (LVMMs) that can be used as a preclinical model to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0c0fd64700f94a87b7ac13de2565ac
https://doi.org/10.1111/j.1476-5381.2009.00338.x
https://doi.org/10.1111/j.1476-5381.2009.00338.x
Autor:
Chris E. Pollard, Najah Abi-Gerges, Ann J. Woods, Ben G Small, Matthew E.L. Hardy, Jean-Pierre Valentin, Matthew Bridgland-Taylor
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 60:94-106
Introduction Evaluation of drug candidates in in-vitro assays of action potential duration (APD) is one component of preclinical safety assessment. Current assays are limited by technically-demanding, time-consuming electrophysiological methods. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb777cdec9eb4d586ef585ea4db6a97
https://doi.org/10.1016/j.vascn.2009.03.005
https://doi.org/10.1016/j.vascn.2009.03.005
Publikováno v:
British Journal of Pharmacology. 154:1516-1522
Proarrhythmia models use electrophysiological markers to predict the risk of torsade de pointes (TdP) in patients. The set of variables used by each model to predict the torsadogenic propensity of a drug has been reported to correlate with clinical o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa5db0709e4a3f8f7cf0f2651860509
https://doi.org/10.1038/bjp.2008.195
https://doi.org/10.1038/bjp.2008.195
Autor:
Najah Abi-Gerges, Jean-Pierre Valentin, Tim G Hammond, Chris L Lawrence, Ben G Small, Chris E. Pollard
Publikováno v:
British Journal of Pharmacology. 147:653-660
As the beagle dog is a commonly used preclinical species to test the effects of new drugs on cardiac repolarisation and Purkinje fibres have become an established in vitro preparation to assess the effects of these new drugs on action potential durat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989a0a213770a4638b2ab10c112cf2db
https://doi.org/10.1038/sj.bjp.0706491
https://doi.org/10.1038/sj.bjp.0706491
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 52:46-59
Prolongation of the QT interval and the cardiac action potential have been linked to a potentially fatal but rare tachyarrhythmia known as Torsades de Pointes (TdP). Nonclinical assays, such as those investigating the effect on I(Kr) (the hERG channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208e32857da78d99e24fcb475816373c
https://doi.org/10.1016/j.vascn.2005.04.011
https://doi.org/10.1016/j.vascn.2005.04.011
Autor:
Jean-Pierre Valentin, Ben G Small, Chris E. Pollard, Najah Abi-Gerges, Tim G Hammond, Chris L Lawrence
Publikováno v:
British Journal of Pharmacology. 142:1255-1264
Women are more prone to develop torsades de pointes, a rare life-threatening polymorphic ventricular tachycardia, than are men during administration of medicines that have the potential to block IKr (rapid delayed rectifier cardiac K+ current) and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7657cc0e00c7a5e51234d9aab0cb912
https://doi.org/10.1038/sj.bjp.0705880
https://doi.org/10.1038/sj.bjp.0705880
Autor:
Joanna Parkinson, Chris E. Pollard, Sandra A.G. Visser, Jean-Pierre Valentin, James W.T. Yates, Lorna Ewart, Philip Jarvis
Publikováno v:
Journal of pharmacological and toxicological methods. 68(3)
Introduction Preclinical assessment of the heart rate corrected QT interval (QTc) is an important component of the cardiovascular safety evaluation in drug discovery. Here we aimed to quantify the translational relationship between QTc prolongation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e60cc96ddb34b198a8952d629ab191
https://pubmed.ncbi.nlm.nih.gov/23567074
https://pubmed.ncbi.nlm.nih.gov/23567074
Autor:
Chris E, Pollard, N, Abi Gerges, M H, Bridgland-Taylor, A, Easter, T G, Hammond, J-P, Valentin
Publikováno v:
British journal of pharmacology. 159(1)
Owing to its association with Torsades de Pointes, drug-induced QT interval prolongation has been and remains a significant hurdle to the development of safe, effective medicines. Genetic and pharmacological evidence highlighting the pivotal role the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f54ff7c21c8d505414286241dabc455
https://pubmed.ncbi.nlm.nih.gov/20141517
https://pubmed.ncbi.nlm.nih.gov/20141517