Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Chris DeSantis"'
Publikováno v:
Journal of the American Chemical Society. 141:9365-9372
We report herein the synthesis and DNA/RNA binding properties of bPNA+, a new variant of bifacial peptide nucleic acid (bPNA) that binds oligo T/U nucleic acids to form triplex hybrids. By virtue of a new bivalent side chain on bPNA+, similar DNA aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd374f7bf1df9568aa11aaea1fdb1811
https://doi.org/10.1021/jacs.9b03435
https://doi.org/10.1021/jacs.9b03435
Publikováno v:
Journal of Chemical Education
The COVID pandemic forced many higher education institutions to pivot and switch to an online learning environment with minimal preparation. This transition was put in place during the middle of the spring semester, in March. During this transition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5790ed15fc403dde275c4cc18b05e541
Publikováno v:
Biochemistry
Herein, we demonstrate context-dependent molecular recognition of DNA by synthetic bPNA iron and copper complexes, using oxidative backbone cleavage as a chemical readout for binding. Oligoethylenimine bPNAs displaying iron·EDTA or copper·phenanthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db984b19cd1359fc06f1a8eb4c00f467
https://pubmed.ncbi.nlm.nih.gov/32519542
https://pubmed.ncbi.nlm.nih.gov/32519542
In this manuscript, we demonstrate the utility of polyacrylates modified with both an artificial base-triple and a sugar (GalNAc) to serve as an siRNA packaging and delivery platform to hepatocytes in culture and in vivo (mice). This work is based up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664df15b580d400c872b9e0c2553a6ba
https://doi.org/10.26434/chemrxiv.7581578.v2
https://doi.org/10.26434/chemrxiv.7581578.v2
We have submitted a new manuscript, entitled “Triplex hybridization of siRNA with bifacial glycopolymer nucleic acid enables hepatocyte-targeted silencing” for consideration as an article in ACS Chemical Biology. My co-authors, Xin Xia, Zhun Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf10566efc2b915d4ef23b5317c66af
https://doi.org/10.26434/chemrxiv.7581578.v1
https://doi.org/10.26434/chemrxiv.7581578.v1