Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Chris D. Rielly"'
Publikováno v:
Chemistry Proceedings, Vol 9, Iss 1, p 21 (2022)
This work aims at the production of uniformly sized, equant shaped crystals using a direct nucleation control (DNC) strategy to help achieve enhanced manufacturability and bioavailability of the active pharmaceutical ingredients (API). A crystallizat
Externí odkaz:
https://doaj.org/article/68e05621793348768219b428493136cf
Publikováno v:
CrystEngComm. 23:8159-8168
Heterogeneous surfaces, such as solid particles, are known to efficiently increase nucleation rates during crystallisations from solution. In this work, air bubbles have been used to act as heterogeneous surfaces, to facilitate the critical nuclei fo
Publikováno v:
Computer Aided Chemical Engineering ISBN: 9780323958790
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7edac0a8a618e32903dd0893c2a5100
https://doi.org/10.1016/b978-0-323-95879-0.50183-1
https://doi.org/10.1016/b978-0-323-95879-0.50183-1
Autor:
Lauren E. Hatcher, Brahim Benyahia, Pollyanna Payne, Chick C. Wilson, Wei Li, Chris D. Rielly
Publikováno v:
Crystal Growth & Design. 20:5854-5862
Additive crystallization routes to control the crystal habit of the active pharmaceutical ingredient (API) lovastatin are presented, at small scale up to 25 mL. Lovastatin is an archetypical example of an API that forms needle-like crystals via solut
Publikováno v:
Journal of Chemical Technology and Biotechnology
BACKGROUND The loss of efficiency and performance of bioprocesses on scale‐up is well known, but not fully understood. This work addresses this problem, by studying the effect of some fermentation gradients (pH, glucose and oxygen) that occur at th
Publikováno v:
Crystal growthdesign. 22(8)
The objective of the research was to improve the process design of a combined antisolvent-cooling crystallization to reduce the degree of agglomeration of a real active pharmaceutical ingredient product, which was manufactured using a crystallization
Publikováno v:
31st European Symposium on Computer Aided Process Engineering ISBN: 9780323885065
In crystallization processes, the control of particle size distribution, shape and purity are crucial to achieve the targeted critical quality attributes of the final drug product and meet the pharmaceutical regulatory requirements. This work present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e6d746eb7a99d7d0b2b2efa0ad0c5c6
https://doi.org/10.1016/b978-0-323-88506-5.50211-4
https://doi.org/10.1016/b978-0-323-88506-5.50211-4
Optimal trajectory tracking control of batch crystallization process based on reinforcement learning
Publikováno v:
Proceedings of The 2nd International Online Conference on Crystals.
Publikováno v:
Proceedings of The 2nd International Online Conference on Crystals.
To improve drug product quality, the size and shape of active pharmaceutical ingredient (API) crystals need to meet tight specifications, in part determined by downstream manufacturing requirements. Improved critical quality attributes may also lead
Publikováno v:
Journal of Chemical Technology & Biotechnology. 94:647-657
Scaled‐down models are small‐scale bioreactors, used to mimic the chemical (pH, nutrient and dissolved oxygen) and physical (pressure, viscosity and temperature) gradients known to occur in the large‐scale fermenter. Conventionally, before scal