Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Chris D. Madsen"'
Autor:
Michael Bartoschek, Nikolay Oskolkov, Matteo Bocci, John Lövrot, Christer Larsson, Mikael Sommarin, Chris D. Madsen, David Lindgren, Gyula Pekar, Göran Karlsson, Markus Ringnér, Jonas Bergh, Åsa Björklund, Kristian Pietras
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putative
Externí odkaz:
https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf
Autor:
Carmen Rodriguez-Cupello, Monica Dam, Laura Serini, Shan Wang, David Lindgren, Emelie Englund, Pontus Kjellman, Håkan Axelson, Alberto García-Mariscal, Chris D. Madsen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffol
Externí odkaz:
https://doaj.org/article/e069d909a6e749478abe8f3b7ee5b908
Autor:
Caroline S. Hill, Erik Sahai, Yigit Erker, Debipriya Das, Chris D. Madsen, Laurence Levy, Marco A. Briones-Orta
Supplementary Figure S6 PDF File - 35K, Validation of RNA-seq data by qPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18664e2b1aa5eeca671d94e1ea1003ba
https://doi.org/10.1158/0008-5472.22399341.v1
https://doi.org/10.1158/0008-5472.22399341.v1
Autor:
Caroline S. Hill, Erik Sahai, Yigit Erker, Debipriya Das, Chris D. Madsen, Laurence Levy, Marco A. Briones-Orta
Supplementary Table S1 PDF File - 52K, Number of tumors observed in the lungs 20 and 30 days post-injection for parental NCI-H460 cells and clones NCI-H460 WT Ark 1 and NCI H460 Ark 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b38690201a7f5ae0cf12b2c513cc14d
https://doi.org/10.1158/0008-5472.22399323.v1
https://doi.org/10.1158/0008-5472.22399323.v1
Autor:
Caroline S. Hill, Erik Sahai, Yigit Erker, Debipriya Das, Chris D. Madsen, Laurence Levy, Marco A. Briones-Orta
Supplementary Legends PDF File - 120K, Legends for Supplementary Figures, Table, and Movies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf2b0a856d5f56a0e14841c5c4a9cb6
https://doi.org/10.1158/0008-5472.22399335
https://doi.org/10.1158/0008-5472.22399335
Autor:
Caroline S. Hill, Erik Sahai, Yigit Erker, Debipriya Das, Chris D. Madsen, Laurence Levy, Marco A. Briones-Orta
Supplementary Movie S1 AVI file - 1075K, GFP-labeled parental MDA-MB-231 cells were seeded on top of a layer of HUVEC cells, and images were acquired every 5 min using a Plan apochromat 20x 0.8 objective on a Zeiss LSM 780 confocal microscope. The mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700f18a97c15ac2c4730ca0aab32e059
https://doi.org/10.1158/0008-5472.22399329
https://doi.org/10.1158/0008-5472.22399329
Autor:
Kristian Pietras, Shan Wang, Vinay Swaminathan, Zhen Li, Emelie Englund, David Lindgren, Chris D. Madsen, Håkan Axelson, Mattia Saggioro, Johannes Kumra Ahnlide, Pontus Kjellman, Ryu Kanzaki, Christelle N. Prinz, Carmen Rodriguez-Cupello
Publikováno v:
Nature Cell Biology. 23:758-770
The YAP/TAZ transcriptional programme is not only a well-established driver of cancer progression and metastasis but also an important stimulator of tissue regeneration. Here we identified Cerebral cavernous malformations 3 (CCM3) as a regulator of m
Autor:
Anu Laitala, Sarah McNeilly, Sina Zendehroud, Lene B. Oddershede, Maria Rafaeva, Wilhelm Bloch, Monica Nicolau, Stefanie Sudhop, Stefanie Kiderlen, Janine T. Erler, Alejandro E Mayorca-Guiliani, Frank Suhr, Carina Prein, Lutz Fleischhauer, Kamilla Westarp Zornhagen, Benjamin Furtwängler, Chris D. Madsen, Denise Nikodemus, Tom Van Agtmael, Kyoung-Jae Won, Hyobin Kim, Erwin M. Schoof, Manuel Koch, Eleni Maniati, Hauke Clausen-Schaumann, Oliver M. T. Pearce, Sebastian R. Nielsen, Lena Wullkopf, Roland R. Netz, Bo T. Porse, Raphael Reuten
Publikováno v:
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, McNeilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-Guiliani, A E, Bloch, W, Netz, R R, Clausen-Schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892-903 . https://doi.org/10.1038/s41563-020-00894-0
Nature Materials
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, Mcneilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-guiliani, A E, Bloch, W, Netz, R R, Clausen-schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892–903 . https://doi.org/10.1038/s41563-020-00894-0
Nature Materials
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, Mcneilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-guiliani, A E, Bloch, W, Netz, R R, Clausen-schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892–903 . https://doi.org/10.1038/s41563-020-00894-0
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in seve
Autor:
Chris D. Madsen, Emelie Englund, Adriana Mañas, Sujeethkumar Prithiviraj, Pontus Kjellman, Anne-Katrine Frank, Alejandro Garcia Garcia, Kristina Aaltonen, Paul Bourgine, Ani Grigoryan, Alexander Balhuizen, Christophe Côme, Dimitra Zacharaki, Bo T. Porse, Nasim Kalantari, Daniel Bexell, Javanshir Esfandyari
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Pre-clinical research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032b3631264950c4e8d6b58d585a4aed
https://doi.org/10.1101/2021.09.11.459806
https://doi.org/10.1101/2021.09.11.459806
Autor:
Alejandro E Mayorca-Guiliani, Oliver Willacy, Raphael Reuten, Chris D. Madsen, Janine T. Erler, Maria Rafaeva
Publikováno v:
Mayorca-Guiliani, A E, Rafaeva, M, Willacy, O, Madsen, C D, Reuten, R & Erler, J T 2021, ' Decellularization of the Murine Cardiopulmonary Complex ', Journal of Visualized Experiments, vol. 171, e61854 . https://doi.org/10.3791/61854
We present here a decellularization protocol for mouse heart and lungs. It produces structural ECM scaffolds that can be used to analyze ECM topology and composition. It is based on a microsurgical procedure designed to catheterize the trachea and ao