Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Chris D, St Laurent"'
Autor:
Ghazaleh Eskandari-Sedighi, Madeline Crichton, Sameera Zia, Erik Gomez-Cardona, Leonardo M. Cortez, Zain H. Patel, Kei Takahashi-Yamashiro, Chris D. St. Laurent, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew S. Macauley
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-27 (2024)
Abstract Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility
Externí odkaz:
https://doaj.org/article/e2bd71e630ca42e2903e16f780fc40b0
Autor:
Cristina Di Carluccio, Linda Cerofolini, Miguel Moreira, Frédéric Rosu, Luis Padilla-Cortés, Giulia Roxana Gheorghita, Zhuojia Xu, Abhishek Santra, Hai Yu, Shinji Yokoyama, Taylor E. Gray, Chris D. St. Laurent, Yoshiyuki Manabe, Xi Chen, Koichi Fukase, Matthew S. Macauley, Antonio Molinaro, Tiehai Li, Barbara A. Bensing, Roberta Marchetti, Valérie Gabelica, Marco Fragai, Alba Silipo
Publikováno v:
ACS Central Science, Vol 10, Iss 2, Pp 447-459 (2024)
Externí odkaz:
https://doaj.org/article/f888054ea1c443f9aeac1a296ab0f10a
Autor:
Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-22 (2021)
Abstract Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 a
Externí odkaz:
https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2
Autor:
Emily Rodrigues, Jaesoo Jung, Heajin Park, Caleb Loo, Sepideh Soukhtehzari, Elena N. Kitova, Fahima Mozaneh, Gour Daskhan, Edward N. Schmidt, Vivian Aghanya, Susmita Sarkar, Laura Streith, Chris D. St. Laurent, Linh Nguyen, Jean-Philippe Julien, Lori J. West, Karla C. Williams, John S. Klassen, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, wh
Externí odkaz:
https://doaj.org/article/c0a8a14897d44e9db090036236f8b1ee
Autor:
Matthew D. Benson, MD, Kimberly M. Papp, BSc, Geoffrey A. Casey, BSc(EE), BSc(MolBiol), Alina Radziwon, BSc, Chris D. St Laurent, BSc, Lance P. Doucette, PhD, Ian M. MacDonald, MD, CM
Publikováno v:
Ophthalmology Science, Vol 1, Iss 2, Pp 100028- (2021)
Purpose: Peroxisomal biogenesis disorders (PBDs) represent a spectrum of conditions that result in vision loss, sensorineural hearing loss, neurologic dysfunction, and other abnormalities resulting from aberrant peroxisomal function caused by mutatio
Externí odkaz:
https://doaj.org/article/53a69df201ae4fe7b07ce21f724d1d22
Autor:
Santiago Tijaro Bulla, Eiman A. Osman, Chris D. St Laurent, Matthew S. Macauley, Julianne M. Gibbs
CRISPR-Cas9 is currently the most versatile technique to perform gene editing in living organisms. In this approach, the Cas9 endonuclease is guided towards its DNA target sequence by the guide RNA (gRNA). Chemical synthesis of a functional 97-nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bb42ba181fec211de747cc38ae91613
https://doi.org/10.26434/chemrxiv-2023-qhhkz
https://doi.org/10.26434/chemrxiv-2023-qhhkz
Autor:
Hansol Park, Eiman A. Osman, Christopher R. Cromwell, Chris D. St Laurent, Yuning Liu, Elena N. Kitova, John S. Klassen, Basil P. Hubbard, Matthew S. Macauley, Julianne M. Gibbs
Publikováno v:
Bioconjugate Chemistry. 33:858-868
Gene-editing systems such as CRISPR-Cas9 readily enable individual gene phenotypes to be studied through loss of function. However, in certain instances, gene compensation can obfuscate the results of these studies, necessitating the editing of multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e87a055248ac42594d1066a86e1361
https://doi.org/10.1021/acs.bioconjchem.2c00106
https://doi.org/10.1021/acs.bioconjchem.2c00106
Autor:
Jhon R. Enterina, Matthew S. Macauley, Chris D. St. Laurent, Kay-Hooi Khoo, Abhishek Bhattacherjee, Chu-Wei Kuo, Wesley F. Zandberg, Fahima Mozaneh, Emily Rodrigues, Parisa Raeisimakiani, Gour Chand Daskhan, Jaesoo Jung, H Nitin, Po-Han Lin, Xuefei Huang, Lara K. Mahal, Duong T Bui, John S. Klassen
Publikováno v:
ACS Chemical Biology. 16:2673-2689
The immunomodulatory family of Siglecs recognize sialic acid-containing glycans as ‘self’, which is exploited in cancer for immune-evasion. The biochemical nature of Siglec ligands remains incompletely understood with emerging evidence suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58d2915757580089f07892034a10641
https://doi.org/10.1021/acschembio.1c00501
https://doi.org/10.1021/acschembio.1c00501
Autor:
Madelene Ho, Chris D. St. Laurent, Kelli A. McCord, Abhishek Bhattacherjee, Ghazaleh Eskandari-Sedighi, Sameera Zia, Matthew S. Macauley, Jaesoo Jung, Gaurav Sidhu, Jason R. Plemel, Arjun Bains, Susmita Sarkar
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-22 (2021)
Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 allele (rs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf832cb6f85bf4d28a1c0ce4f84ecb4b
https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2
https://doaj.org/article/9d903e7fcaaf46188f4b75d343f185d2
Autor:
Abhishek Bhattacherjee, Chris D. St. Laurent, Ghazaleh Eskandari-Sedighi, Gour Chand Daskhan, Anastassia Voronova, Arjun Bains, Adrianne E.S. Watson, Matthew S. Macauley
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 338
CD33 is an immunomodulatory receptor expressed by microglia and genetically linked to Alzheimer's disease (AD) susceptibility. While antibodies targeting CD33 have entered clinical trials to treat neurodegeneration, it is unknown whether the glycan-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850efb12eeb818fbbff2d850a13cea6b
https://pubmed.ncbi.nlm.nih.gov/34517042
https://pubmed.ncbi.nlm.nih.gov/34517042