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Akademický článek

Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndromeResearch in context

Autor: Mauro S.B. Silva, Elodie Desroziers, Sabine Hessler, Melanie Prescott, Chris Coyle, Allan E. Herbison, Rebecca E. Campbell

Publikováno v: EBioMedicine, Vol 44, Iss , Pp 582-596 (2019)

Background: Enhanced GABA activity in the brain and a hyperactive hypothalamic-pituitary-gonadal axis are associated with polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility. Women with PCOS exhibit elevated cerebrospina

Externí odkaz: https://doaj.org/article/04e185871f794c2aa414df5e6871c075

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Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndrome

Autor: Chris Coyle, Mauro S.B. Silva, Rebecca Campbell, Elodie Desroziers, Allan E. Herbison, Sabine Hessler, Melanie Prescott

Publikováno v: EBioMedicine. 44:582-596

Background Enhanced GABA activity in the brain and a hyperactive hypothalamic-pituitary-gonadal axis are associated with polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility. Women with PCOS exhibit elevated cerebrospinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6dde7de86c4b334605d23752aa0a0c
https://doi.org/10.1016/j.ebiom.2019.05.065

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Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus

Autor: Perry Barrett, Kenneth G. Onishi, Javier Tello, Chris Coyle, Tyler J. Stevenson, Federico Caso, Elisabetta Tolla

TJS thanks the British Society for Neuroendocrinology and the Society for Reproduction and Fertility for research project funds. PB acknowledges the Scottish Government for funding. Experiments investigated neuroanatomically localized changes in de n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4ed694b2377f1ba4af2fe033aeea7a
https://hdl.handle.net/10023/21382

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Chronic Excess of Non-Aromatizable Androgens From Puberty Does Not Drive a Neuroendocrine Phenotype Observed in Other Preclinical Rodent Models of PCOS

Autor: Chris Coyle, Amy Ruddenklau, Mel Prescott, Kirsty A Walters, Rebecca Campbell

Publikováno v: Journal of the Endocrine Society

Polycystic ovary syndrome (PCOS) is the most common form of anovulatory infertility in women of reproductive age, characterised by androgen excess, polycystic appearance of the ovary and irregular menstruation. PCOS is also frequently associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e73751f42500abf300f6d377bc3823a
http://europepmc.org/articles/PMC8090661

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Pathological pulses in PCOS

Autor: Rebecca Campbell, Chris Coyle

Publikováno v: Molecular and cellular endocrinology. 498

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder associated with hyperandrogenism and anovulation. Although a spectrum disorder, many women with PCOS exhibit elevated luteinizing hormone (LH) pulse frequency and an elevated L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be51df3dce92b6436b92a7b86e0a161
https://pubmed.ncbi.nlm.nih.gov/31461666

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Cyclical DNA Methyltransferase 3a Expression Is a Seasonal and Estrus Timer in Reproductive Tissues

Autor: Eloise W. J. Lynch, Alan S. Bowman, Chris Coyle, Tyler J. Stevenson, Ewan M. Campbell, Marlene Lorgen

Publikováno v: Endocrinology. 157:2469-2478

It is becoming clear that epigenetic modifications such as DNA methylation can be dynamic and, in many cases, reversible. Here we investigated the photoperiod and hormone regulation of DNA methylation in testes, ovaries, and uterine tissue across mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b87961787887d07d815cc5f9051200
https://doi.org/10.1210/en.2015-1988

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Photoperiodic and ovarian steroid regulation of histone deacetylase 1, 2, and 3 in Siberian hamster (Phodopus sungorus) reproductive tissues

Autor: Chris Coyle, Tyler J. Stevenson, Eloise W. J. Lynch

Publikováno v: General and comparative endocrinology. 246

Epigenetic modifications in reproductive tissues have predominantly focused on pathological conditions, such as ovarian and uterine cancers. The contribution of DNA methylation and histone acetylation to the timing and control of fertility is not wel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ddfdab0b93eea7252fa52192b0835
https://pubmed.ncbi.nlm.nih.gov/28017732

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Cyclical DNA methyltransferase and histone deacetylase expression across multiple timescales in the uterus of the Siberian hamster (Phodopus sungorus)

Autor: Tyler J. Stevenson, Eloise W. J. Lynch, Chris Coyle

Publikováno v: Reproduction Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2848cbad53887b77a003191c601adbf8
https://doi.org/10.1530/repabs.3.o007

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(Invited) Direct Conversion of Methane to Methanol and Other Value Products in SOFC

Autor: Olga A Marina, Evgueni Polikarpov, Lirong Zhong, Alex Mitroshkov, Larry Pederson, Chris Coyle, Gregory W Coffey

Publikováno v: ECS Meeting Abstracts. :3071-3071

The direct conversion of methane to liquid fuels and chemicals is highly sought, especially at low-scale to more effectively utilize remote natural gas resources. Direct conversion has proven to be a very difficult problem, because methane is highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::374ebe90244ee2e93a210f918d86c923
https://doi.org/10.1149/ma2016-02/40/3071

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