Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Chris Chung Sing Chan"'
Autor:
Ming Liu, Bingtai Lu, Yue Li, Shuofeng Yuan, Zhen Zhuang, Guangyu Li, Dong Wang, Liuheyi Ma, Jianheng Zhu, Jinglu Zhao, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Kenn Ka-Heng Chik, Zhiyao Zhao, Huifang Xian, Jingxian Zhao, Jincun Zhao, Jasper Fuk-Woo Chan, Yuxia Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant impact on healthcare systems and economies worldwide. The continuous emergence of new viral strai
Externí odkaz:
https://doaj.org/article/c02112b836a14ac28ad39f3d5eb26d75
Autor:
Biao Zhou, Runhong Zhou, Jasper Fuk-Woo Chan, Jianwei Zeng, Qi Zhang, Shuofeng Yuan, Li Liu, Rémy Robinot, Sisi Shan, Na Liu, Jiwan Ge, Hugo Yat-Hei Kwong, Dongyan Zhou, Haoran Xu, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Hin Chu, Ming Yue, Ka-Yi Kwan, Chun-Yin Chan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Zhenglong Du, Ka-Kit Au, Haode Huang, Hiu-On Man, Jianli Cao, Cun Li, Ziyi Wang, Jie Zhou, Youqiang Song, Man-Lung Yeung, Kelvin Kai-Wang To, David D. Ho, Lisa A. Chakrabarti, Xinquan Wang, Linqi Zhang, Kwok-Yung Yuen, Zhiwei Chen
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Prevention of robust severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in nasal turbinate (NT) requires in vivo evaluation of IgA neutralizing antibodies. Here, we report the efficacy of receptor binding domain (RBD)-specific mon
Externí odkaz:
https://doaj.org/article/06e5de52ccad4802879063fc0fd250b8
Autor:
Ronghui Liang, Zi-Wei Ye, Chon Phin Ong, Zhenzhi Qin, Yubin Xie, Yilan Fan, Kaiming Tang, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Xiaomeng Yang, Hehe Cao, Kun Wang, Haoran Sun, Bodan Hu, Jian-Piao Cai, Cuiting Luo, Kenn Ka-Heng Chik, Hin Chu, Yi Zheng, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Dong-Yan Jin, Shuofeng Yuan
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2093-2101 (2022)
The replication and pathogenicity of SARS-CoV-2 Omicron BA.2 are comparable to that of BA.1 in experimental animal models. However, BA.2 has rapidly emerged to overtake BA.1 to become the predominant circulating SARS-CoV-2 variant worldwide. Here, we
Externí odkaz:
https://doaj.org/article/b55a2f57759b43ee8b1fbc2b83098836
Autor:
Biao Zhou, Runhong Zhou, Bingjie Tang, Jasper Fuk-Woo Chan, Mengxiao Luo, Qiaoli Peng, Shuofeng Yuan, Hang Liu, Bobo Wing-Yee Mok, Bohao Chen, Pui Wang, Vincent Kwok-Man Poon, Hin Chu, Chris Chung-Sing Chan, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Ka-Kit Au, Hiu-On Man, Lu Lu, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen, Shangyu Dang, Zhiwei Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicro
Externí odkaz:
https://doaj.org/article/36f166867713422db16d612a9572ffc2
Autor:
Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yong Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan, Kelvin Wai-Kwok Yeung
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Although extrapulmonary complications of different organ systems are recognized in patients with severe COVID19 effects are less well studied. Here, Qiao et al. characterize the pathogenesis of SARS-CoV-2 on bone metabolism in Syrian hamster and find
Externí odkaz:
https://doaj.org/article/fb441b0001af4a89876779dbf201b795
Autor:
Tomokazu Yamaguchi, Midori Hoshizaki, Takafumi Minato, Satoru Nirasawa, Masamitsu N. Asaka, Mayumi Niiyama, Masaki Imai, Akihiko Uda, Jasper Fuk-Woo Chan, Saori Takahashi, Jianbo An, Akari Saku, Ryota Nukiwa, Daichi Utsumi, Maki Kiso, Atsuhiro Yasuhara, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Yuji Fujino, Satoru Motoyama, Satoshi Nagata, Josef M. Penninger, Haruhiko Kamada, Kwok-Yung Yuen, Wataru Kamitani, Ken Maeda, Yoshihiro Kawaoka, Yasuhiro Yasutomi, Yumiko Imai, Keiji Kuba
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-
Externí odkaz:
https://doaj.org/article/37a0f877c7f0425f889b230ea8fdf522
Autor:
Hanjun Zhao, Kelvin K. W. To, Hoiyan Lam, Xinxin Zhou, Jasper Fuk-Woo Chan, Zheng Peng, Andrew C. Y. Lee, Jianpiao Cai, Wan-Mui Chan, Jonathan Daniel Ip, Chris Chung-Sing Chan, Man Lung Yeung, Anna Jinxia Zhang, Allen Wing Ho Chu, Shibo Jiang, Kwok-Yung Yuen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo
Externí odkaz:
https://doaj.org/article/7afe365d9513460da362a27eacf0cb49
Autor:
Bao-Zhong Zhang, Xiaolei Wang, Shuofeng Yuan, Wenjun Li, Ying Dou, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Kenn KaHeng Chik, Kaiming Tang, Chris Chun-Yiu Chan, Ye-Fan Hu, Jing-Chu Hu, Smaranda Ruxandra Badea, Hua-Rui Gong, Xuansheng Lin, Hin Chu, Xuechen Li, Kelvin Kai-Wang To, Li Liu, Zhiwei Chen, Ivan Fan-Ngai Hung, Kwok Yung Yuen, Jasper Fuk-Woo Chan, Jian-Dong Huang
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 874-884 (2021)
The Coronavirus Disease 2019 (COVID-19) pandemic is unlikely to abate until sufficient herd immunity is built up by either natural infection or vaccination. We previously identified ten linear immunodominant sites on the SARS-CoV-2 spike protein of w
Externí odkaz:
https://doaj.org/article/5541589f744e4dea8384c34ffc7a4702
Autor:
Zi-Wei Ye, Shuofeng Yuan, Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Ching-Yun Yu, Chon Phin Ong, Dong Yang, Chris Chun-Yiu Chan, Kaiming Tang, Jianli Cao, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Hin Chu, Kwok-Yung Yuen, Dong-Yan Jin
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 291-304 (2021)
Effective treatments for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Dexamethasone has been shown to confer survival benefits to certain groups of hospitalized patien
Externí odkaz:
https://doaj.org/article/7b85688b98f94ddbba93c4479cc9dc95
Autor:
Huiping Shuai, Jasper Fuk-Woo Chan, Terrence Tsz-Tai Yuen, Chaemin Yoon, Jing-Chu Hu, Lei Wen, Bingjie Hu, Dong Yang, Yixin Wang, Yuxin Hou, Xiner Huang, Yue Chai, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Lu Lu, Rui-Qi Zhang, Wan-Mui Chan, Jonathan Daniel Ip, Allen Wing-Ho Chu, Ye-Fan Hu, Jian-Piao Cai, Kwok-Hung Chan, Jie Zhou, Siddharth Sridhar, Bao-Zhong Zhang, Shuofeng Yuan, Anna Jinxia Zhang, Jian-Dong Huang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Hin Chu
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103643- (2021)
Background: Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-CoV-2 variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike that has been suggested to associate with an increased recognition of mouse ACE2
Externí odkaz:
https://doaj.org/article/9dcd3276c6884e1cb41446a790d36182