Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells

Autor: Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Paola Cornejo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O’ Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda

SummaryHematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - bind regulatory eleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41942e05e1ce4a56162d13a406b33d8c
https://doi.org/10.1101/2023.04.18.537282

Mesoderm-derived PDGFRA

Autor: Vashe, Chandrakanthan, Prunella, Rorimpandey, Fabio, Zanini, Diego, Chacon, Jake, Olivier, Swapna, Joshi, Young Chan, Kang, Kathy, Knezevic, Yizhou, Huang, Qiao, Qiao, Rema A, Oliver, Ashwin, Unnikrishnan, Daniel R, Carter, Brendan, Lee, Chris, Brownlee, Carl, Power, Robert, Brink, Simon, Mendez-Ferrer, Grigori, Enikolopov, William, Walsh, Berthold, Göttgens, Samir, Taoudi, Dominik, Beck, John E, Pimanda

Publikováno v: Nature cell biology. 24(8)

Mouse haematopoietic stem cells (HSCs) first emerge at embryonic day 10.5 (E10.5), on the ventral surface of the dorsal aorta, by endothelial-to-haematopoietic transition. We investigated whether mesenchymal stem cells, which provide an essential nic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bc7c1c4c85047e3ffd504d405af0e46
https://pubmed.ncbi.nlm.nih.gov/35902769

Unexpected host dependency of Antarctic Nanohaloarchaeota

Autor: Martin A. Smith, Shaun Carswell, Timothy J. Williams, Sarah Brazendale, Chris Brownlee, Ling Zhong, Mark J. Raftery, Allegra Angeloni, Ricardo Cavicchioli, Susanne Erdmann, Alyce M. Hancock, Michelle A. Allen, Joshua N Hamm, Emiley A. Eloe-Fadrosh, Kirston Barton

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 29
Proceedings of the National Academy of Sciences of the United States of America

Significance We demonstrate that Candidatus Nanohaloarchaeum antarcticus requires Halorubrum lacusprofundi for growth, illustrating that Nanohaloarchaeota require a host rather than being free living as previously proposed. Developing the means of cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1816761b205731e5ec7ff9eb5dcb159d
https://escholarship.org/uc/item/7n91964x

Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Definitive Hematopoiesis

Autor: Young Chan Kang, John E. Pimanda, Carl Power, Chris Brownlee, Brendan Lee, Rema A. Oliver, Qiao Qiao, Vashe Chandrakanthan, Dominik Beck, Kathy Knezevic, Ashwin Unnikrishnan

Publikováno v: Mechanisms of Development. 145:S55-S56

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28ad9b8120cfdf625b01ad1d1e6a126a
https://doi.org/10.1016/j.mod.2017.04.109