Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Chris Boshoff"'
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1833-1841 (2014)
APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC signature mutations occur at high frequency in cervical cancers (CESC), over
Externí odkaz:
https://doaj.org/article/f206e1c685524a278c6bf04162cb2729
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004400 (2014)
Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KS tumour cells display features of
Externí odkaz:
https://doaj.org/article/31d4ddc1da7c4f0c917825280bf144af
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.
Autor:
Victoria Emuss, Dimitrios Lagos, Arnold Pizzey, Fiona Gratrix, Stephen R Henderson, Chris Boshoff
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000616 (2009)
Increased expression of Notch signaling pathway components is observed in Kaposi sarcoma (KS) but the mechanism underlying the manipulation of the canonical Notch pathway by the causative agent of KS, Kaposi sarcoma herpesvirus (KSHV), has not been f
Externí odkaz:
https://doaj.org/article/c0c852d5360c4fc39ab192ad09a59dca
Autor:
Rebecca C Robey, Dimitrios Lagos, Fiona Gratrix, Stephen Henderson, Nick C Matthews, Richard J Vart, Mark Bower, Chris Boshoff, Frances M Gotch
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5890 (2009)
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), the most common malignancy in untreated individuals with HIV/AIDS. The adaptive T-cell immune response against KSHV has not been fully characterized. To achi
Externí odkaz:
https://doaj.org/article/7634a9f174c849208c374355c5b934b4
Autor:
Nora Mutalima, Elizabeth Molyneux, Harold Jaffe, Steve Kamiza, Eric Borgstein, Nyengo Mkandawire, George Liomba, Mkume Batumba, Dimitrios Lagos, Fiona Gratrix, Chris Boshoff, Delphine Casabonne, Lucy M Carpenter, Robert Newton
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2505 (2008)
Burkitt lymphoma, a childhood cancer common in parts of sub-Saharan Africa, has been associated with Epstein Barr Virus (EBV) and malaria, but its association with human immunodeficiency virus (HIV) is not clear.We conducted a case-control study of B
Externí odkaz:
https://doaj.org/article/30b95ed305b840458690d7a6213fe3bd
Autor:
Chris Boshoff, Nessa Carey, Laurence Wild, Stephen Henderson, Juan M. Funes, James M. Flanagan
Supplementary Table S4 from Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53bcc5a33358ef6aa7733c28cf7b545
https://doi.org/10.1158/1535-7163.22483698.v1
https://doi.org/10.1158/1535-7163.22483698.v1
Autor:
Nita Ahuja, Stephen B. Baylin, Kornel E. Schuebel, James G. Herman, Christine A. Iacobuzio-Donahue, Matty P. Weijenberg, Manon van Engeland, Kim M. Smits, Chris Boshoff, Juan M. Funes, Craig M. Hooker, Marilia de Freitas Calmon, Sabine C. Glöckner, Jana Jeschke, Stephanie R. Downing, Leander Van Neste, Mashaal Dhir, Joo Mi Yi
Purpose: The importance of genetic and epigenetic alterations maybe in their aggregate role in altering core pathways in tumorigenesis.Experimental Design: Merging genome-wide genomic and epigenomic alterations, we identify key genes and pathways alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8582dc340df4f26b275d021a95cced32
https://doi.org/10.1158/1078-0432.c.6519395
https://doi.org/10.1158/1078-0432.c.6519395
Autor:
Chris Boshoff, Nessa Carey, Laurence Wild, Stephen Henderson, Juan M. Funes, James M. Flanagan
Since the sequencing of the human genome, recent efforts in cancer drug target discovery have focused more on the identification of novel functions of known genes and the development of more appropriate tumor models. In the present study, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299b98443513cd7466ea97e7c0152552
https://doi.org/10.1158/1535-7163.c.6531213.v1
https://doi.org/10.1158/1535-7163.c.6531213.v1
Autor:
Nita Ahuja, Stephen B. Baylin, Kornel E. Schuebel, James G. Herman, Christine A. Iacobuzio-Donahue, Matty P. Weijenberg, Manon van Engeland, Kim M. Smits, Chris Boshoff, Juan M. Funes, Craig M. Hooker, Marilia de Freitas Calmon, Sabine C. Glöckner, Jana Jeschke, Stephanie R. Downing, Leander Van Neste, Mashaal Dhir, Joo Mi Yi
CCR Translation for This Article from Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a35872f75443096e51aeae5f401a9de
https://doi.org/10.1158/1078-0432.22442729
https://doi.org/10.1158/1078-0432.22442729
Autor:
Chris Boshoff, Nessa Carey, Laurence Wild, Stephen Henderson, Juan M. Funes, James M. Flanagan
Supplementary Fig from Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bd6fbe5eddfa45ca8a19c048b877ab
https://doi.org/10.1158/1535-7163.22483710.v1
https://doi.org/10.1158/1535-7163.22483710.v1