Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Chris B. Schaffer"'
Autor:
Seth Lieberman, Daniel A. Rivera, Ryan Morton, Amrit Hingorani, Teresa L. Southard, Lynn Johnson, Jennifer Reukauf, Ryan E. Radwanski, Mingrui Zhao, Nozomi Nishimura, Oliver Bracko, Theodore H. Schwartz, Chris B. Schaffer
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract In partial onset epilepsy, seizures arise focally in the brain and often propagate. Patients frequently become refractory to medical management, leaving neurosurgery, which can cause neurologic deficits, as a primary treatment. In the cortex
Externí odkaz:
https://doaj.org/article/d22684f893044b91ac604fc32f314fdc
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/42a03ce2a673476487af60ad53485dbe
Publikováno v:
Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Electrical neural recordings measured using direct electrical interfaces with neural tissue suffer from a short lifespan because the signal strength decreases over time. The inflammatory response to the inserted microprobe can create insulat
Externí odkaz:
https://doaj.org/article/00d038b4fc60488eaf31b75d9b9b220b
Autor:
Oliver Bracko, Lindsay K. Vinarcsik, Jean C. Cruz Hernández, Nancy E. Ruiz-Uribe, Mohammad Haft-Javaherian, Kaja Falkenhain, Egle M. Ramanauskaite, Muhammad Ali, Aditi Mohapatra, Madisen A. Swallow, Brendah N. Njiru, Victorine Muse, Pietro E. Michelucci, Nozomi Nishimura, Chris B. Schaffer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Obesity is linked to increased risk for and severity of Alzheimer’s disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We recently showed that non-flowing capillaries, caused by ad
Externí odkaz:
https://doaj.org/article/e9f076f1a1ac4a1ca9d345e6325e1739
Autor:
Amy F. Smith, Vincent Doyeux, Maxime Berg, Myriam Peyrounette, Mohammad Haft-Javaherian, Anne-Edith Larue, John H. Slater, Frédéric Lauwers, Pablo Blinder, Philbert Tsai, David Kleinfeld, Chris B. Schaffer, Nozomi Nishimura, Yohan Davit, Sylvie Lorthois
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Despite the key role of the capillaries in neurovascular function, a thorough characterization of cerebral capillary network properties is currently lacking. Here, we define a range of metrics (geometrical, topological, flow, mass transfer, and robus
Externí odkaz:
https://doaj.org/article/5c6eea44e62e4684b2c3294c3d750b78
Publikováno v:
Structural Dynamics, Vol 3, Iss 5, Pp 054301-054301-19 (2016)
Knowledge of protein structure provides essential insight into function, enhancing our understanding of diseases and enabling new treatment development. X-ray crystallography has been used to solve the structures of more than 100 000 proteins; howeve
Externí odkaz:
https://doaj.org/article/75cd408d3de043518209609fe6683ee3
Autor:
Zachary T. Hilt, Wisler Charles, Katarina E. Cheng, Cybelle Tabilas, Megan Steinhilber, Samantha P. Wesnak, Norah L. Smith, Chris B. Schaffer, Brian D. Rudd
Publikováno v:
The Journal of Immunology. 209:2281-2286
CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing
Autor:
Kaja Falkenhain, Nancy E Ruiz-Uribe, Mohammad Haft-Javaherian, Muhammad Ali, Stall Catchers, Pietro E Michelucci, Chris B Schaffer, Oliver Bracko
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235691 (2020)
Exercise exerts a beneficial effect on the major pathological and clinical symptoms associated with Alzheimer's disease in humans and mouse models of the disease. While numerous mechanisms for such benefits from exercise have been proposed, a clear u
Externí odkaz:
https://doaj.org/article/0521d3d81acc40cd8c8991ee0a0c0624
Autor:
Kara A. Zielinski, Shuo Sui, Suzette A. Pabit, Daniel A. Rivera, Tong Wang, Qingyue Hu, Maithri M. Kashipathy, Stella Lisova, Chris B. Schaffer, Valerio Mariani, Mark S. Hunter, Christopher Kupitz, Frank R. Moss, Frédéric P. Poitevin, Thomas D. Grant, Lois Pollack
Publikováno v:
bioRxiv
RNA macromolecules, like proteins, fold to assume shapes that are intimately connected to their broadly recognized biological functions; however, because of their high charge and dynamic nature, RNA structures are far more challenging to determine. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b885ff5ce5121ba5ca2fc76f661ff1b2
https://europepmc.org/articles/PMC10245879/
https://europepmc.org/articles/PMC10245879/
Autor:
Pavel Sidorenko, Michael Buttolph, Menansili Mejooli, Chi-Yong Eom, Chris B. Schaffer, Frank Wise
Publikováno v:
Biomed Opt Express
Two-photon excited fluorescence microscopy is a widely-employed imaging technique that enables the noninvasive study of biological specimens in three dimensions with sub-micrometer resolution. Here, we report an assessment of a gain-managed nonlinear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e4235fc2729eafd0f13ef838533de6
https://europepmc.org/articles/PMC10191666/
https://europepmc.org/articles/PMC10191666/