Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Chris A. Tarling"'
Autor:
Georg Schitter, Elisabeth Scheucher, Andreas J. Steiner, Arnold E. Stütz, Martin Thonhofer, Chris A. Tarling, Stephen G. Withers, Jacqueline Wicki, Katrin Fantur, Eduard Paschke, Don J. Mahuran, Brigitte A. Rigat, Michael Tropak, Tanja M. Wrodnigg
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 21 (2010)
N-Alkylation at the ring nitrogen of the D-galactosidase inhibitor 1-deoxygalactonojirimycin with a functionalised C6 alkyl chain followed by modification with different aromatic substituents provided lipophilic 1-deoxygalactonojirimycin derivatives
Externí odkaz:
https://doaj.org/article/758f56058e784db1bcd1da10f98431f3
Autor:
Adeleke Aguda, Leonard J. Foster, Jacqueline Wicki, Ethan D. Goddard-Borger, Gary D. Brayer, Christina Tysoe, Robert A. Keyzers, Stephen G. Withers, Leslie K. Williams, Nham T. Nguyen, Raymond J. Andersen, Suzanne Perry, Chris A. Tarling
Publikováno v:
ACS Central Science
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Selective inhibitors of human pancreatic α-amylase (HPA) are an effective means of controlling blood sugar levels in the management of diabetes. A high-throughput screen of marine natural product extracts led to the identification of a potent (Ki =
Autor:
Katrin Fantur, Gerit Pototschnig, Arnold E. Stütz, Don J. Mahuran, Georg Schitter, Stephen G. Withers, Robert Saf, Brigitte Rigat, Andreas Steiner, Carina Illaszewicz, Eduard Paschke, Chris A. Tarling, Elisabeth Scheucher, Michael B. Tropak, Tanja M. Wrodnigg, Martin Thonhofer
Publikováno v:
ChemBioChem. 11:2026-2033
A collection of new reversible glycosidase inhibitors of the iminoalditol type featuring N-substituents containing perfluorinated regions has been prepared for evaluation of physicochemical, biochemical and diagnostic properties. The vast variety of
Autor:
James M. Macdonald, Chris A. Tarling, Edward J. Taylor, Rebecca J. Dennis, David S. Myers, Spencer Knapp, Gideon J. Davies, Stephen G. Withers
Publikováno v:
Angewandte Chemie. 122:2653-2656
Publikováno v:
Analytical Biochemistry. 382:48-54
A high-throughput screen to detect the synthesis of natural and non-natural gangliosides by cell lysates has been developed and automated. Utilizing the binding specificity of cholera toxin B-subunit for the oligosaccharide moiety of the ganglioside
Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols—A proof-of-concept study
Autor:
Albin Hermetter, Chris A. Tarling, Stephen G. Withers, Andreas Steiner, Arnold E. Stütz, Tanja M. Wrodnigg, Hannes Schmidinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1922-1925
Three typical glycosidase-inhibiting iminoalditols were attached to a polyamine surface displayed on a silicon chip. Exposure to a representative beta-glucosidase revealed selective binding events reflecting the different structural features of the i
Publikováno v:
Carbohydrate Research. 342:1850-1858
Cyclization by double reductive amination of D-xylo-hexos-5-ulose with the terminal amino group of alpha-N-Boc-lysine methyl ester gave a 4:1-mixture of (1'R)-N-methoxycarbonyl-(1-N-Boc-amino)pentyl-1-deoxynojirimycin and the corresponding L-ido epim
Autor:
Emily Kwan, Stephen G. Withers, Jacqueline Wicki, Mario Schubert, David K. Y. Poon, Jens Erik Nielsen, Lawrence P. McIntosh, Chris A. Tarling
Publikováno v:
Biochemistry. 46:7383-7395
We have characterized by NMR spectroscopy the three active site (His80, His85, and His205) and two non-active site (His107 and His114) histidines in the 34 kDa catalytic domain of Cellulomonas fimi xylanase Cex in its apo, noncovalently aza-sugar-inh
Publikováno v:
Biochemistry. 46:6996-7005
The contributions of enzyme-substrate hydrogen-binding interactions to catalysis by two different families of xylanases were evaluated through kinetic studies with two representative wild-type enzymes, Cellulomonas fimi xylanase (Cex) and Bacillus ci
Autor:
Andreas Steiner, Stefan Ully, Tanja M. Wrodnigg, Stephen G. Withers, Arnold E. Stütz, Inge Lundt, Chris A. Tarling
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1737-1742
1,5-Dideoxy-1,5-imino- d -glucitol, the corresponding d - manno and l - ido epimers as well as the powerful β-glucosidase inhibitor isofagomine were N-alkylated with di-, tri-, as well as tetraethylene glycol derived straight chain spacer arms by a