Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Chris A. Edwards"'
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation
Autor:
Sorif Uddin, Augustin Amour, David J. Lewis, Chris D. Edwards, Matthew G. Williamson, Simon Hall, Lisa A. Lione, Edith M. Hessel
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Phosphoinositide-3-kinase-delta (PI3Kδ) inhibition is a promising therapeutic approach for inflammatory conditions due to its role in leucocyte proliferation, migration and activation. However, the effect of PI3Kδ inhibition on
Externí odkaz:
https://doaj.org/article/257ef4c6a3614587b0988d96a2e954dd
Autor:
Jessica L. Puranda, Danilo F. da Silva, Chris M. Edwards, Taniya S. Nagpal, Sara S. Souza, Kevin Semeniuk, Kristi B. Adamo
Publikováno v:
Journal of Women's Health. 32:199-207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe9174ee23786279b39a487daa3dc26
https://doi.org/10.1089/jwh.2021.0647
https://doi.org/10.1089/jwh.2021.0647
Publikováno v:
International Journal of Engine Research. 24:1916-1937
Previous efforts aimed at increasing the efficiencies of systems where a piston engine serves as a primary work producer have led to interest in operating direct-injection, compression-ignition (DI/CI) engines at overall stoichiometric or fuel-rich e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce976be2d842c682f30a3d76a5b87cba
https://doi.org/10.1177/14680874221105703
https://doi.org/10.1177/14680874221105703
Autor:
Catherine Everest, Danilo F. da Silva, Jessica Puranda, Sara C.S. Souza, Alexandra D. Goudreau, Taniya S. Nagpal, Chris M. Edwards, Rhea Gupta, Kristi B. Adamo
Publikováno v:
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC.
Maternal serum and umbilical cord (UC) lipid and glucose levels are influenced by a variety of maternal factors over the course of pregnancy, including maternal physical activity (PA) levels and gestational weight gain (GWG). However, previous resear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ed1d6a7110fd585fa6c8b4fdc59fd5
https://pubmed.ncbi.nlm.nih.gov/36216221
https://pubmed.ncbi.nlm.nih.gov/36216221
Autor:
Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
Publikováno v:
Journal of medicinal chemistry. 64(18)
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd30d2dabfe0764f96af2bbb1bd2724
https://pubmed.ncbi.nlm.nih.gov/34510892
https://pubmed.ncbi.nlm.nih.gov/34510892
Autor:
Chris D. Edwards, Edward Taylor, Rebecca H Graves, Olivia J. Robb, Brett O'Brien, Andrew W Harrell, Edith M. Hessel, Augustin Amour, Aarti Patel, Neil A Miller
Publikováno v:
Clinical pharmacokinetics. 61(2)
Physiologically based pharmacokinetic (PBPK) modelling has evolved to accommodate different routes of drug administration and enables prediction of drug concentrations in tissues as well as plasma. The inhalation route of administration has proven su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81f740786cad5a758f64fe8d78e115d
https://pubmed.ncbi.nlm.nih.gov/34458976
https://pubmed.ncbi.nlm.nih.gov/34458976
Autor:
Giovanna Bergamini, Stefano Livia, Kenneth David Down, Marcus Bantscheff, Nick Barton, Friedrich B M Reinhard, Paola Grandi, Daniel Thomas, David N. Mallett, Paul Martin Gore, Sophie M. Bertrand, Z.A. Henley, Edith M. Hessel, James E. Rowedder, Mark Price, J. Nicole Hamblin, Birgit Dümpelfeld, Augustin Amour, Steve Keeling, Christina Rau, Máire A. Convery, Chris D. Edwards, Jonathan A. Taylor, Paul Rowland, Aoife C. Maxwell
Publikováno v:
Journal of Medicinal Chemistry. 63:638-655
Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee509ec4ce8051c7f53718e7e95b2637
https://doi.org/10.1021/acs.jmedchem.9b01585
https://doi.org/10.1021/acs.jmedchem.9b01585
Autor:
Malcolm Begg, Eleni Pefani, Jonathan Clark, Carla F. Newman, Miriam Marotti, Martin I. Hingle, Disala Fernando, David N. Mallett, Anthony Cahn, Sorif Uddin, Filzah Ehtesham, Josie Morrell, Robert Wilson, Giovanni Vitulli, J. Nicole Hamblin, Jane Gilbert, Chris D. Edwards, Edith M. Hessel, Andrew W Harrell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:443-453
This study describes the pharmacokinetic (PK) and pharmaco-dynamic (PD) profile of N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide (GSK2292767A), a novel low-solubility inhaled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d458b382120aa5c2397a9f4a956bd6f
https://doi.org/10.1124/jpet.119.257311
https://doi.org/10.1124/jpet.119.257311
Autor:
Chris Margaret Edwards, Danilo F. da Silva, Sara C.S. Souza, Jessica L. Puranda, Taniya S. Nagpal, kevin Semeniuk, Kristi B. Adamo
Publikováno v:
Medicine & Science in Sports & Exercise. 54:139-139
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd14cf8b6d46af414e1bdcb83278ec9
https://doi.org/10.1249/01.mss.0000876780.96756.37
https://doi.org/10.1249/01.mss.0000876780.96756.37
Autor:
Jennifer Y. Liu, Owen W. Peng, Alan Y. Lu, Alexander Kizhner, Ashley R. Gao, Mark C. Xu, Zita T. Chan, Kelly A. Hu, Elisa De Togni, Erica P. Ryu, Barrie Cascella, Sophia Shi, Luis A. Goicouria, Cynthia K. Holland, Erin M. Hall, Rebecca S. Yang, Maria L. Sorkin, Soon Goo Lee, Patricia L. Walker, Regina Liu, Grace Wang, Chris T. Edwards, Trenton J. Dawson, Katherine Huang, Andrew Z. Lin, Kaleena Zhang, Sheri A. McClerkin, Josephine S. Lee, Kelsie C. Kodama, Wilhelm Cruz, Barbara N. Kunkel, Joseph M. Jez, Isabel K. Eng
Publikováno v:
Bioscience Reports. 40
Aldehyde dehydrogenases (ALDHs) catalyze the conversion of various aliphatic and aromatic aldehydes into corresponding carboxylic acids. Traditionally considered as housekeeping enzymes, new biochemical roles are being identified for members of ALDH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7870a7d75c8cb3b0dc27ec7bbf38bd1d
https://doi.org/10.1042/bsr20202959
https://doi.org/10.1042/bsr20202959