Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Chris A Kieslich"'
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148974 (2016)
HIV-1 entry into host cells is mediated by interactions between the V3-loop of viral glycoprotein gp120 and chemokine receptor CCR5 or CXCR4, collectively known as HIV-1 coreceptors. Accurate genotypic prediction of coreceptor usage is of significant
Externí odkaz:
https://doaj.org/article/4b76a8ead4ba4ad8a2232cf06eb8836f
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49925 (2012)
The V3 loop of the glycoprotein 120 (gp120) is a contact point for cell entry of HIV-1 leading to infection. Despite sequence variability and lack of specific structure, the highly flexible V3 loop possesses a well-defined role in recognizing and sel
Externí odkaz:
https://doaj.org/article/a02e42bae4d146e4bbe997edaeb4c708
Autor:
Chris A Kieslich, Dimitrios Morikis
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 12, p e1002840 (2012)
The interaction between complement fragment C3d and complement receptor 2 (CR2) is a key aspect of complement immune system activation, and is a component in a link between innate and adaptive immunities. The complement immune system is an ancient me
Externí odkaz:
https://doaj.org/article/801ec3caa0eb4f88a3f9beb56c33a176
Autor:
Rohith R. Mohan, Mark Wilson, Ronald D. Gorham, Reed E. S. Harrison, Vasilios A. Morikis, Chris A. Kieslich, Asuka A. Orr, Alexis V. Coley, Phanourios Tamamis, Dimitrios Morikis
Publikováno v:
ACS Omega, Vol 3, Iss 6, Pp 6427-6438 (2018)
Externí odkaz:
https://doaj.org/article/275d093bb4fb465ab24b9e2d7c7c11b9
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: Cysteine cathepsins are implicated in breast cancer progression, produced by both transformed epithelial cells and infiltrated stromal cells in tumors, but to date, no cathepsin inhibitor has been approved for clinical use due to unexpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ab133efc27416261bab9eb2d8bb24a
https://doi.org/10.1007/s12195-019-00580-5
https://doi.org/10.1007/s12195-019-00580-5
Publikováno v:
31st European Symposium on Computer Aided Process Engineering ISBN: 9780323885065
With the emergence of new pathogens, e.g., methicillin-resistant Staphylococcus aureus (MRSA), and the recent novel coronavirus pandemic, there has been an ever-increasing need for novel antimicrobial therapeutics. In this work, we have developed sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe850873cacbf491ca67d4f6986a7b0
https://doi.org/10.1016/b978-0-323-88506-5.50312-0
https://doi.org/10.1016/b978-0-323-88506-5.50312-0
Publikováno v:
AIChE J
In this article, we present (1) a feature selection algorithm based on nonlinear support vector machine (SVM) for fault detection and diagnosis in continuous processes and (2) results for the Tennessee Eastman benchmark process. The presented feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1b776452d2449fc47c6b7d69abbbfc
https://pubmed.ncbi.nlm.nih.gov/32377021
https://pubmed.ncbi.nlm.nih.gov/32377021
Autor:
Melis Onel, Chris A. Kieslich, Yannis A. Guzman, Christodoulos A. Floudas, Efstratios N. Pistikopoulos
Publikováno v:
Computers & Chemical Engineering. 116:503-520
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::306680e678c447f797ffc74c4e0128dc
https://doi.org/10.1016/j.compchemeng.2018.10.016
https://doi.org/10.1016/j.compchemeng.2018.10.016
Autor:
Phanourios Tamamis, Ronald D. Gorham, Dimitrios Morikis, Alexis V. Coley, Rohith R. Mohan, Chris A. Kieslich, Reed E.S. Harrison, Mark Wilson, Vasilios A. Morikis, Asuka A. Orr
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 6, Pp 6427-6438 (2018)
ACS Omega, Vol 3, Iss 6, Pp 6427-6438 (2018)
The complement system is our first line of defense against foreign pathogens, but when it is not properly regulated, complement is implicated in the pathology of several autoimmune and inflammatory disorders. Compstatin is a peptidic complement inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a934b4aa3aa48fe883b87210b320ef1
http://europepmc.org/articles/PMC6130793
http://europepmc.org/articles/PMC6130793
Publikováno v:
Journal of Global Optimization. 71:845-869
A surrogate-based optimization method is presented, which aims to locate the global optimum of box-constrained problems using input–output data. The method starts with a global search of the n-dimensional space, using a Smolyak (Sparse) grid which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a41e77c4c401b575f062e69961774fca
https://doi.org/10.1007/s10898-018-0643-0
https://doi.org/10.1007/s10898-018-0643-0