Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Chris, Bladen"'
Publikováno v:
Anser. 2022, Vol. 61 Issue 2, p56-61. 6p.
Autor:
Thomas Harman, Michael Udoh, Dan L. McElroy, Lyndsey L. Anderson, Richard C. Kevin, Samuel D. Banister, Adam Ametovski, Jack Markham, Chris Bladen, Peter T. Doohan, Quentin Greba, Robert B. Laprairie, Terrance P. Snutch, Iain S. McGregor, John G. Howland, Jonathon C. Arnold
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: T-type Ca2+ channels (Cav3) represent emerging therapeutic targets for a range of neurological disorders, including epilepsy and pain. To aid the development and optimisation of new therapeutics, there is a need to identify novel chemical
Externí odkaz:
https://doaj.org/article/8b1b021c9bdb4638b63894720a9176fe
Autor:
Michael Udoh, Chris Bladen, Marika Heblinski, Jia Lin Luo, Vaishali S. Janve, Lyndsey L. Anderson, Iain S. McGregor, Jonathon C. Arnold
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Introduction: Cannabidiol (CBD) has been clinically approved for intractable epilepsies, offering hope that novel anticonvulsants in the phytocannabinoid class might be developed. Looking beyond CBD, we have recently reported that a series of biosynt
Externí odkaz:
https://doaj.org/article/2ac18aa921254e2e99480afe336e1cce
Autor:
Shivani Sachdev, Samuel D. Banister, Marina Santiago, Chris Bladen, Michael Kassiou, Mark Connor
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Synthetic cannabinoid receptor agonists (SCRAs) are new psychoactive substances associated with acute intoxication and even death. However, the molecular mechanisms through which SCRAs may exert their toxic effects remain unclear—including
Externí odkaz:
https://doaj.org/article/f0169851f2814f0abf981ce1dee90fed
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-6 (2018)
Abstract N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission. However, excessive activity of thes
Externí odkaz:
https://doaj.org/article/4d5b15efef6542db946d37b8936708ea
Publikováno v:
Cannabis Cannabinoid Res
Introduction: Low voltage-activated T-type calcium channels (T-type I(Ca)), Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3, are opened by small depolarizations from the resting membrane potential in many cells and have been associated with neurological disorders,
Autor:
Somayeh Mirlohi, Chris Bladen, Marina J. Santiago, Jonathon C. Arnold, Iain McGregor, Mark Connor
Publikováno v:
British Journal of Pharmacology. 179:4031-4043
T-type Ca channels (IA fluorometric (fluorescence imaging plate reader [FLIPR]) assay was used to investigate modulation of human T-type IIn the FLIPR assay, all 11 phytocannabinoids tested modulated T-type IModulation of T-type calcium channels is a
Autor:
Richard C. Kevin, Somayeh Mirlohi, Jamie J. Manning, Rochelle Boyd, Elizabeth A. Cairns, Adam Ametovski, Felcia Lai, Jia Lin Luo, William Jorgensen, Ross Ellison, Roy R. Gerona, David E. Hibbs, Iain S. McGregor, Michelle Glass, Mark Connor, Chris Bladen, Gerald W. Zamponi, Samuel D. Banister
Publikováno v:
ACS Chemical Neuroscience. 13:1395-1409
Publikováno v:
Cannabis and Cannabinoid Research. 7:34-45
IntroductionLow voltage-activated T-type calcium channels (T-type ICa), CaV3.1, CaV3.2, and CaV3.3 are opened by small depolarizations from the resting membrane potential in many cells and have been associated with neurological disorders including ab
Autor:
Agustin Garcia-Caballero, Vinicius M. Gadotti, Md Yousof Ali, Chris Bladen, Eder Gambeta, Jeffrey F. Van Humbeck, Justin L. MacCallum, Gerald W. Zamponi
Publikováno v:
ACS chemical neuroscience. 13(4)
Cav3.2 calcium channels are important mediators of nociceptive signaling in the primary afferent pain pathway, and their expression is increased in various rodent models of chronic pain. Previous work from our laboratory has shown that this is in par