Výsledky vyhledávání - "Chris, Arthur"

Akademický článek

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

Autor: Stefan Gerhardy, Mark Ultsch, Wanjian Tang, Evan Green, Jeffrey K. Holden, Wei Li, Alberto Estevez, Chris Arthur, Irene Tom, Alexis Rohou, Daniel Kirchhofer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The protease HTRA1 is a genetic risk factor for geographic atrophy. Here, Gerhardy et al. describe its inhibition by a clinical Fab, whose binding locks it in an inactive state. The mechanism identifies an essential function of LoopA with this protea

Externí odkaz: https://doaj.org/article/55461e6817b145b7b4f3d1b202ec723c

Zobrazit plný text záznamu

Akademický článek

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing

Publikováno v: Viruses, Vol 15, Iss 12, p 2335 (2023)

Marburg virus (MARV) causes severe disease and high mortality in humans. The objective of this study was to characterize disease manifestations and pathogenesis in cynomolgus macaques exposed to MARV. The results of this natural history study may be

Externí odkaz: https://doaj.org/article/888ce560fbcf4156b170e652f06b91dc

Zobrazit plný text záznamu

Elektronická kniha

On the Shoreline of Knowledge : Irish Wanderings

Autor: Chris Arthur

The carefully crafted, meditative essays in On the Shoreline of Knowledge sometimes start from unlikely objects or thoughts, a pencil or some fragments of commonplace conversation, but they soon lead the reader to consider fundamental themes in human

Zobrazit plný text záznamu

Akademický článek

Spontaneous coronary artery dissection in the third trimester—Implications for investigation and delivery

Autor: Thomas Paxton‐Hall, Pranali Desai, Nicholas Seton, Chris Arthur

Publikováno v: Clinical Case Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)

Abstract This case of spontaneous coronary artery dissection in pregnancy highlights the diagnostic, treatment and delivery dilemmas in the antepartum period. This is a rare condition that usually manifests in the postpartum period. This case provide

Externí odkaz: https://doaj.org/article/085bb7b72c514fb1a7eb42f22cf2a7d3

Zobrazit plný text záznamu

Elektronická kniha

The New Dialectic and Marx's Capital

Autor: Chris Arthur

This book both argues for, and demonstrates, a new turn to dialectic. Marx's Capital was clearly influenced by Hegel's dialectical figures: here, case by case, the significance of these is clarified. More, it is argued that, instead of the dialectic

Zobrazit plný text záznamu