Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Chozhavendan Rathinam"'
Autor:
Chozhavendan Rathinam, Christoph Klein
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e306 (2007)
Hematopoietic stem cell differentiation is specified by cytokines and transcription factors, but the mechanisms controlling instructive and permissive signalling networks are poorly understood. We provide evidence that CLP1-dependent IL7-receptor med
Externí odkaz:
https://doaj.org/article/cb02ebc1381b49529dc5524f7685af91
Publikováno v:
Stem cell research
Stem Cell Research, Vol 33, Iss, Pp 199-205 (2018)
Stem Cell Research, Vol 33, Iss, Pp 199-205 (2018)
Inflammatory signals have been shown to play a critical role in controlling the maintenance and functions of hematopoietic stem cells (HSCs). While the significance of inflammation in hematopoiesis has begun to unfold, molecular mechanisms and player
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b47213c1fbdf9f2bb46c4f2b7be5d0
https://doi.org/10.1016/j.scr.2018.10.020
https://doi.org/10.1016/j.scr.2018.10.020
Autor:
Richard A. Flavell, David M. Valenzuela, George D. Yancopoulos, Markus G. Manz, Wojtek Auerbach, Chozhavendan Rathinam, Sean Stevens, Elizabeth E. Eynon, Hitoshi Takizawa, Anthony Rongvaux, Andrew J. Murphy, Tim Willinger
Hematopoietic stem cells (HSCs) both self-renew and give rise to all blood cells for the lifetime of an individual. Xenogeneic mouse models are broadly used to study human hematopoietic stem and progenitor cell biology in vivo. However, maintenance,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daccb12ab6dde2f0602de8f36aad625
http://doc.rero.ch/record/324259/files/rongvaux_pnas_2011.pdf
http://doc.rero.ch/record/324259/files/rongvaux_pnas_2011.pdf
Publikováno v:
Stem Cells. 34:1343-1353
Hematopoietic stem cells (HSCs) are capable of both self-renewing throughout the lifetime of an organism and differentiating into all lineages of the blood system. A proper balance between quiescence and proliferation is critical for the self-renewal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e221cf32e13bc823570171d7f6b9cc
https://doi.org/10.1002/stem.2302
https://doi.org/10.1002/stem.2302
Publikováno v:
Cell reports
Cell Reports, Vol 25, Iss 8, Pp 2094-2109.e4 (2018)
Cell Reports, Vol 25, Iss 8, Pp 2094-2109.e4 (2018)
SUMMARY Constitutive activation of the canonical NF-κB pathway has been associated with a variety of human pathologies. However, molecular mechanisms through which canonical NF-κB affects hematopoiesis remain elusive. Here, we demonstrate that dere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe96f9cc0dde4df59fb146646be1f6
https://pubmed.ncbi.nlm.nih.gov/30463008
https://pubmed.ncbi.nlm.nih.gov/30463008
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Inflammation and inflammatory cytokines have been shown to exert both positive and negative effects on hematopoietic stem cells (HSCs) and hematopoiesis. While the significance of inflammation driven hematopoiesis has begun to unfold, molecular playe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ce6b004415ee0b34ddac89018ca386
https://pubmed.ncbi.nlm.nih.gov/31477755
https://pubmed.ncbi.nlm.nih.gov/31477755
Publikováno v:
EMBO reports. 15:775-783
A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a ubiquitin-editing enzyme that removes K63-linked ubiquitin chains from adaptor proteins, such as RIP1, and then conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97ef056641b6c635e8823ca31120c6b
https://doi.org/10.15252/embr.201338305
https://doi.org/10.15252/embr.201338305
Publikováno v:
Proceedings of the National Academy of Sciences. 109:3457-3462
Development of type 1 diabetes in the nonobese diabetic (NOD) mouse is preceded by an immune cell infiltrate in the pancreatic islets. The exact role of the attracted cells is still poorly understood. Chemokine CCL2/MCP-1 is known to attract CCR2 + m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028968632e5132190edd03d86e1d62d1
https://doi.org/10.1073/pnas.1115308109
https://doi.org/10.1073/pnas.1115308109
Autor:
Chozhavendan Rathinam, Richard A. Flavell, Indrajit Sinha, Minghui Zeng, Ramin Massoumi, Neesar Ahmed, Wei Zen Wei, Lisa Polin, K. Venuprasad
Publikováno v:
Nature immunology
Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162ecce7dc4f9e7b4750b7d2ad71aeeb
http://europepmc.org/articles/PMC3219826
http://europepmc.org/articles/PMC3219826
Autor:
Richard A. Flavell, Liming Hao, Samuel Huber, William T. O'Connor, Chozhavendan Rathinam, Susumu Nakae, Masahito Kamanaka, Yisong Y. Wan, Lauren A. Zenewicz, Yoichiro Iwakura, Nicola Gagliani
Publikováno v:
The Journal of Experimental Medicine
Interleukin-10 acts directly on CD45RBlo but not CD45RBhi cells to control colitis upon transfer into Rag1-deficient recipients.
The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated
The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3ee7dcc099f9e0e1262a0dd657f77e
https://doi.org/10.1084/jem.20102149
https://doi.org/10.1084/jem.20102149