CD38-PyP2 axis-mediated signaling impedes CD8⁺ T cell response to anti-PD1 therapy in cancer.

Autor: Kar, Anwesha, Ghosh, Puspendu, Gautam, Anupam, Chowdhury, Snehanshu, Basak, Debashree, Sarkar, Ishita, Bhoumik, Arpita, Barman, Shubhrajit, Chakraborty, Paramita, Mukhopadhyay, Asima, Mehrotra, Shikhar, Ganesa, Senthil Kumar, Paul, Sandip, Chatterjee, Shilpak

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 3/12/2024, Vol. 121 Issue 11, p1-12, 30p

Intratumoral PD1 + CD38 + Tim3 + CD8 + T Cells in Pre-BCG Tumor Tissues Are Associated with Poor Responsiveness to BCG Immunotherapy in Patients with Non-Muscle Invasive Bladder Cancer.

Autor: Basak, Debashree, Mondal, Soumya, Srivastava, Swadeep Kumar, Sarkar, Deborpita, Sarkar, Ishita, Basu, Sukanya, Bhoumik, Arpita, Chowdhury, Snehanshu, Pal, Dilip Kumar, Chatterjee, Shilpak

Publikováno v: Cells (2073-4409); Aug2023, Vol. 12 Issue 15, p1939, 12p

CD38-RyR2 axis-mediated signaling impedes CD8 ⁺ T cell response to anti-PD1 therapy in cancer.

Autor: Kar A; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India., Ghosh P; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India., Gautam A; Algorithms in Bioinformatics, Institute for Bioinformatics and Medical Informatics, University of Tübingen, Sand 14 72076, Tübingen, Baden-Württemberg, Germany.; International Max Planck Research School 'From Molecules to Organisms', Max Planck Institute for Biology Tübingen 72076, Tübingen, Baden-Württemberg, Germany., Chowdhury S; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India., Basak D; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India., Sarkar I; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India., Bhoumik A; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India., Barman S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India.; Division of Structural Biology & Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India., Chakraborty P; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina SC- 29425., Mukhopadhyay A; Kolkata Gynaecology Oncology Trials and Translational Research Group, Kolkata 700156, West Bengal, India., Mehrotra S; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina SC- 29425., Ganesan SK; Division of Structural Biology & Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India., Paul S; System Biology Informatics Lab, Center for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata 700091, West Bengal, India., Chatterjee S; Division of Cancer Biology and Inflammatory Disorder, Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 12; Vol. 121 (11), pp. e2315989121. Date of Electronic Publication: 2024 Mar 07.