The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

Autor: Chen, Yanxia, Moutal, Aubin, Navratilova, Edita, Kopruszinski, Caroline, Yue, Xu, Ikegami, Megumi, Chow, Michele, Kanazawa, Iori, Bellampalli, Shreya Sai, Xie, Jennifer, Patwardhan, Amol, Rice, Kenner, Fields, Howard, Akopian, Armen, Neugebauer, Volker, Dodick, David, Khanna, Rajesh, Porreca, Frank

Publikováno v: Science translational medicine, vol 12, iss 529

Pain is more prevalent in women for reasons that remain unclear. We have identified a mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) promoted by prolactin (PRL) in females. PRL signals through mutually inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::320210e2ace5d53eee8236dc774dd0f9
https://escholarship.org/uc/item/20d0v7sz

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.

Autor: Chen Y; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Moutal A; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Navratilova E; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Kopruszinski C; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Yue X; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Ikegami M; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Chow M; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Kanazawa I; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Bellampalli SS; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Xie J; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Patwardhan A; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Rice K; National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA., Fields H; Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA., Akopian A; University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA., Neugebauer V; Texas Tech University Health Science Center, Lubbock, TX 79430, USA., Dodick D; Mayo Clinic, Scottsdale, AZ 85752, USA., Khanna R; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Porreca F; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ 85724, USA. frankp@medadmin.arizona.edu.; Mayo Clinic, Scottsdale, AZ 85752, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Feb 05; Vol. 12 (529).