Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Autor: Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Alicia Stievenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela Vogt Weisenhorn, Wolfgang Wurst, Armin Giese, Francisco Pan-Montojo

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Parkinson´s disease (PD) pathology progresses throughout the nervous system. Whereas motor symptoms are always present, there is a high variability in the prevalence of non-motor symptoms. It has been postulated that the progression of the

Externí odkaz: https://doaj.org/article/df9b737ba1f5425f9e76fb14819c51e7

Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury

Autor: Laura Empl, Alexandra Chovsepian, Maryam Chahin, Wing Yin Vanessa Kan, Julie Fourneau, Valérie Van Steenbergen, Sanofer Weidinger, Maite Marcantoni, Alexander Ghanem, Peter Bradley, Karl Klaus Conzelmann, Ruiyao Cai, Alireza Ghasemigharagoz, Ali Ertürk, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Sabine Liebscher, Florence M. Bareyre

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Which contralesional circuits adapt after traumatic brain injury (TBI) is unclear. Here the authors used in vivo imaging, retrograde labeling, rabies tracing, clearing and functional imaging to demonstrate that callosal neurons selectively adapt afte

Externí odkaz: https://doaj.org/article/1ae8af63caf147c5851d208a6526975f

A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity

Autor: Alexandra Chovsepian, Daniel Berchtold, Katarzyna Winek, Uta Mamrak, Inés Ramírez Álvarez, Yanina Dening, Dominika Golubczyk, Luis Weitbrecht, Claudia Dames, Marine Aillery, Celia Fernandez‐Sanz, Zdzislaw Gajewski, Marianne Dieterich, Miroslaw Janowski, Peter Falkai, Piotr Walczak, Nikolaus Plesnila, Andreas Meisel, Francisco Pan‐Montojo

Publikováno v: Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)

Abstract Stroke is the second leading cause of death and disability worldwide. Current treatments, such as pharmacological thrombolysis or mechanical thrombectomy, reopen occluded arteries but do not protect against ischemia‐induced damage that occ

Externí odkaz: https://doaj.org/article/4c17a29e254942508edb664ac0ac7987

A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity.

Autor: Chovsepian, Alexandra¹ (AUTHOR), Berchtold, Daniel² (AUTHOR), Winek, Katarzyna² (AUTHOR), Mamrak, Uta³ (AUTHOR), Ramírez Álvarez, Inés^4,5 (AUTHOR), Dening, Yanina^1,4 (AUTHOR), Golubczyk, Dominika⁶ (AUTHOR), Weitbrecht, Luis² (AUTHOR), Dames, Claudia² (AUTHOR), Aillery, Marine² (AUTHOR), Fernandez‐Sanz, Celia^4,5 (AUTHOR), Gajewski, Zdzislaw⁷ (AUTHOR), Dieterich, Marianne^4,5 (AUTHOR), Janowski, Miroslaw⁸ (AUTHOR), Falkai, Peter¹ (AUTHOR), Walczak, Piotr⁸ (AUTHOR), Plesnila, Nikolaus^3,5 (AUTHOR), Meisel, Andreas² (AUTHOR), Pan‐Montojo, Francisco^1,4,5 (AUTHOR) Francisco.Pan-Montojo@med.uni-muenchen.de

Publikováno v: Advanced Science. 2/3/2022, Vol. 9 Issue 4, p1-19. 19p.

PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy

Autor: Susann Schröder, Thu Hang Lai, Magali Toussaint, Mathias Kranz, Alexandra Chovsepian, Qi Shang, Sladjana Dukić-Stefanović, Winnie Deuther-Conrad, Rodrigo Teodoro, Barbara Wenzel, Rareş-Petru Moldovan, Francisco Pan-Montojo, Peter Brust

Publikováno v: Molecules, Vol 25, Iss 7, p 1633 (2020)

The adenosine A2A receptor (A2AR) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A2AR availability has been found in the human striatum at early stages of PD and in patients

Externí odkaz: https://doaj.org/article/a6ba38be238e498699ccd57b2c5d72c9