Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chou-Hong Tann"'
Autor:
Xiongwei Shi, Junning Lee, Chou-Hong Tann, Mcallister Timothy L, T. K. Thiruvengadam, Xiaoyong Fu
Publikováno v:
Organic Process Research & Development. 7:692-695
An efficient process for the preparation of 10-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (7), an intermediate to an antitumor agent SCH 66336, is described. This one-pot method consists of a selective reduction of 8-chloro-
Publikováno v:
Tetrahedron Letters. 44:801-804
The S alcohol in the benzylic position of compound 2, a key feature of a novel cholesterol lowering agent Ezetimibe, was introduced by the (R)-MeCBS catalyzed asymmetric carbonyl reduction of ketone 1 using borane tetrahydrofuran complex (BTHF) as th
Publikováno v:
Steroids. 67:549-554
Two new C-nor/D-homo corticosteroids were isolated from the filtrate of the triene carbonate intermediate during the production of betamethasone. Their structures were elucidated based on NMR spectroscopic studies and mass spectral analyses. The mech
Autor:
Chou-Hong Tann, S. Anna Jiang, Mcallister Timothy L, Xiaoyong Fu, T. K. Thiruvengadam, Shuyi Zhang, Fucheng Zhang, Jianguo Yin
Publikováno v:
Tetrahedron Letters. 43:573-576
The palladium-catalyzed cross coupling Heck reaction of tosylate ( 2 ) and methyl acrylate has been developed as an efficient method for carboncarbon bond formation. The tosylate ( 2 ) was reacted with methyl acrylate using palladium acetate as ca
Publikováno v:
Organic Process Research & Development. 5:376-382
Corticosteroid 9,11β-epoxides are key intermediates in the preparation of pharmaceutically important compounds such as betamethasone, mometasone, beclomethasone, and dexamethasone. A new process for the 9,11β-epoxide was developed using a PCl5-medi
Publikováno v:
Tetrahedron Letters. 42:2639-2642
A regioselective PCl 5 -induced dehydration of 11α-hydroxy corticosteroids was invented to provide the corresponding Δ 9,11 double bond trienes in excellent yield (>90%) with 99:1 regioisomeric ratio to the Δ 11,12 isomers. A syn -elimination mech
Publikováno v:
ChemInform. 32
A regioselective PCl 5 -induced dehydration of 11α-hydroxy corticosteroids was invented to provide the corresponding Δ 9,11 double bond trienes in excellent yield (>90%) with 99:1 regioisomeric ratio to the Δ 11,12 isomers. A syn -elimination mech
Publikováno v:
ChemInform. 32
Autor:
Shuyi Zhang, Fucheng Zhang, T. K. Thiruvengadam, Chou-Hong Tann, Xiaoyong Fu, S. Anna Jiang, Mcallister Timothy L, Jianguo Yin
Publikováno v:
ChemInform. 33
The palladium-catalyzed cross coupling Heck reaction of tosylate ( 2 ) and methyl acrylate has been developed as an efficient method for carboncarbon bond formation. The tosylate ( 2 ) was reacted with methyl acrylate using palladium acetate as ca
Autor:
D. John Aberhart, Chou-Hong Tann
Publikováno v:
Bioorganic Chemistry. 10:375-387
Nuclear magnetic resonance methods have been developed for assignment of the absolute configuration of (4,4,4- d 3 )-β-hydroxyisovalerate and (2- d 1 )-β-hydroxyisovalerate. ( E ) and ( Z )-(4,4,4- d 3 )-β-methylcrotonate and (2- d )-β-methylcrot