Výsledky vyhledávání

Akademický článek

Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

Autor: Chou Sunwen, Hartline Caroll B, Frederick Samuel L, Gill Rachel B, Prichard Mark N

Publikováno v: Virology Journal, Vol 6, Iss 1, p 9 (2009)

Abstract The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motif

Externí odkaz: https://doaj.org/article/148a5a0c458f494ca7057bbb1a3da719

Zobrazit plný text záznamu

Akademický článek

Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice

Autor: Chou Sunwen, Komazin Gloria, Bidanset Deborah J, Quenelle Debra C, Prichard Mark N, Drach John C, Kern Earl R

Publikováno v: Virology Journal, Vol 3, Iss 1, p 18 (2006)

Abstract Inhibition of the human cytomegalovirus UL97 kinase by maribavir is thought to be responsible for the antiviral activity of this compound. Some mutations that confer resistance to maribavir map to UL97, however additional mutations that also

Externí odkaz: https://doaj.org/article/c0b429a53c0f4f918fb5b11aeddd1060

Zobrazit plný text záznamu

Akademický článek

Analysis of the human cytomegalovirus genomic region from UL146 through UL147A reveals sequence hypervariability, genotypic stability, and overlapping transcripts

Autor: Huang Diana D, Ware Carl F, Bhorade Sangeeta M, Lichy Heather M, Fox Andrea M, Lurain Nell S, Kwan Sau-Ping, Garrity Edward R, Chou Sunwen

Publikováno v: Virology Journal, Vol 3, Iss 1, p 4 (2006)

Abstract Background Although the sequence of the human cytomegalovirus (HCMV) genome is generally conserved among unrelated clinical strains, some open reading frames (ORFs) are highly variable. UL146 and UL147, which encode CXC chemokine homologues

Externí odkaz: https://doaj.org/article/a00f8ee947bc4085b9e334df856e3445

Zobrazit plný text záznamu