Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Chou Long Huang"'
Autor:
Lewis Mann, Patrick Ten Eyck, Chaorong Wu, Maria Story, Sree Jenigiri, Jayesh Patel, Iiro Honkanen, Kandi O'Connor, Janis Tener, Meenakshi Sambharia, Mony Fraer, Lama Noureddine, Douglas Somers, Jonathan Nizar, Lisa Antes, Sarat Kuppachi, Melissa Swee, Elizabeth Kuo, Chou-Long Huang, Diana I Jalal, Benjamin R Griffin
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0306216 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0278550.].
Externí odkaz:
https://doaj.org/article/b2695cb196654c0bab0fdff04fbe25f1
Autor:
Ru-pin Alicia Chi, Xiaojiang Xu, Jian-Liang Li, Xin Xu, Guang Hu, Paula Brown, Cynthia Willson, Oleksandr Kirsanov, Christopher Geyer, Chou-Long Huang, Marcos Morgan, Francesco DeMayo
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107616- (2023)
Summary: WNK1 is an important regulator in many physiological functions, yet its role in male reproduction is unexplored. In the male germline, WNK1 is upregulated in preleptotene spermatocytes indicating possible function(s) in spermatogenic meiosis
Externí odkaz:
https://doaj.org/article/d47ae584b41947e0acbc4325621d253b
Autor:
Xin Jin, Jian Xie, Chia-Wei Yeh, Jen-Chi Chen, Chih-Jen Cheng, Cheng-Chang Lien, Chou-Long Huang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Maintaining internal osmolality constancy is essential for life. Release of arginine vasopressin (AVP) in response to hyperosmolality is critical. Current hypotheses for osmolality sensors in circumventricular organs (CVOs) of the brain focus on mech
Externí odkaz:
https://doaj.org/article/88c834904d0b4678b48994bb0beda76e
Autor:
Gabriel C. Baccam, Jian Xie, Xin Jin, Hyejung Park, Bing Wang, Hervé Husson, Oxana Ibraghimov-Beskrovnaya, Chou-Long Huang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract A significant population of patients with chronic kidney disease (CKD) develops cardiac hypertrophy, which can lead to heart failure and sudden cardiac death. Soluble klotho (sKL), the shed ectodomain of the transmembrane protein klotho, pro
Externí odkaz:
https://doaj.org/article/dc4c66cb84784ecfa69801c093ee0755
Autor:
Lewis Mann, Patrick Ten Eyck, Chaorong Wu, Maria Story, Sree Jenigiri, Jayesh Patel, Iiro Honkanen, Kandi O'Connor, Janis Tener, Meenakshi Sambharia, Mony Fraer, Lama Nourredine, Douglas Somers, Jonathan Nizar, Lisa Antes, Sarat Kuppachi, Melissa Swee, Elizabeth Kuo, Chou-Long Huang, Diana I Jalal, Benjamin R Griffin
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0278550 (2023)
BackgroundFilter clotting is a major issue in continuous kidney replacement therapy (CKRT) that interrupts treatment, reduces delivered effluent dose, and increases cost of care. While a number of variables are involved in filter life, treatment moda
Externí odkaz:
https://doaj.org/article/89ba3fc1c9c34b6cae73bfd26a7050a4
Autor:
Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L. J. Tybulewicz, Teresa Fernandes-Alnemri, Emad S. Alnemri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses.
Externí odkaz:
https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6c
Autor:
Meng-Hsuan Lin, Jen-Chi Chen, Xuejiao Tian, Chia-Ming Lee, I-Shing Yu, Yi-Fen Lo, Shinichi Uchida, Chou-Long Huang, Bi-Chang Chen, Chih-Jen Cheng
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
The prevailing view is that the ClC-Ka chloride channel (mouse Clc-k1) functions in the thin ascending limb to control urine concentration, whereas the ClC-Kb channel (mouse Clc-k2) functions in the thick ascending limb (TAL) to control salt reabsorp
Externí odkaz:
https://doaj.org/article/1179e61209f04855a4e431e99348e335
Autor:
Dingxiao Liu, Qiong Ding, Dao-Fu Dai, Biswajit Padhy, Manasa K. Nayak, Can Li, Madison Purvis, Heng Jin, Chang Shu, Anil K. Chauhan, Chou-Long Huang, Massimo Attanasio
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Loss of function of the lipid kinase diacylglycerol kinase ε (DGKε), encoded by the gene DGKE, causes a form of atypical hemolytic uremic syndrome that is not related to abnormalities of the alternative pathway of the complement, by mechanisms that
Externí odkaz:
https://doaj.org/article/e2727f9ef2284dc1bee239ff707aae6f
Autor:
Ru-pin Alicia Chi, Tianyuan Wang, Chou-Long Huang, San-pin Wu, Steven L. Young, John P. Lydon, Francesco J. DeMayo
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
WNK1 (with no lysine [K] kinase 1) is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans, which is associated with abnormal ion homeostasis. WNK1 is critical for in vitr
Externí odkaz:
https://doaj.org/article/9cd769b8a4f046ccbce9ce99614ee48b
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229799 (2020)
α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and functions as a circulating cardioprotective hormone. Diacylglycer
Externí odkaz:
https://doaj.org/article/e2b07f9005b64c349dcc5e3f50ed897f