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Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype

Autor: Chorba, John S., Galvan, Adri M., Shokat, Kevan M.

Publikováno v: In Journal of Biological Chemistry 9 February 2018 293(6):1875-1886

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Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor

Autor: Smith, Geoffrey A, Padmanabhan, Arun, Lau, Bryan H, Pampana, Akhil, Li, Li, Lee, Clara Y, Pelonero, Angelo, Nishino, Tomohiro, Sadagopan, Nandhini, Xia, Vivian Q, Jain, Rajan, Natarajan, Pradeep, Wu, Roland S, Black, Brian L, Srivastava, Deepak, Shokat, Kevan M, Chorba, John S

Publikováno v: Science translational medicine, vol 14, iss 662

The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::61e6fea383d4332d07409c16fe989e71
https://escholarship.org/uc/item/41x481zw

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Autor: Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O'Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher JP, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O'Neal, Michael C, Cai, Yiming, Chang, Jason CJ, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

Publikováno v: Nature, vol 583, iss 7816

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease2019 (COVID-19), has infected over 2.3million people, led to the death of more than 160,000 individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e8058324cbb409fab87343810c30041b
https://escholarship.org/uc/item/1ch8v2qc