Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Chor Sang, Chim"'
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a CpG island is present at the putative promoter region of its host gene, AATK, we postulated that the intronic miR-1250-5p is a tumor suppressor miRNA co-
Externí odkaz:
https://doaj.org/article/61b3baf18cab4d368945422ad0e06b29
Autor:
Kwan Yeung Wong, Gareth J. Morgan, Eileen M. Boyle, Alfred Sze Lok Cheng, Kevin Yuk-Lap Yip, Chor Sang Chim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Enhancer DNA methylation and expression of MYBPHL was studied in multiple myeloma (MM). By bisulfite genomic sequencing, among the three CpGs inside the MYBPHL enhancer, CpG1 was significantly hypomethylated in MM cell lines (6.7–50.0%) th
Externí odkaz:
https://doaj.org/article/d58c3083d67245f89af33385adaad2f0
Autor:
Zhenhai Li, Shaji Kumar, Dong-Yan Jin, George A. Calin, Wee-Joo Chng, Kam-Leung Siu, Ming-Wai Poon, Chor Sang Chim
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Long non-coding RNA (lncRNA) BM742401 is a tumor suppressor in gastric cancer and chronic lymphocytic leukemia. As the promoter and coding region of BM742401 are fully embedded in a CpG island, we hypothesized that BM742401 is a t
Externí odkaz:
https://doaj.org/article/d3c86104b68540d6a11e229081eaa60f
Autor:
Hoi Ki Karen Tang, Chi Yeung Fung, Gareth J. Morgan, Shaji Kumar, Lisa Siu, Ho Wan Alvin Ip, Sze Fai Yip, Ka Ngai Harry Lau, Chi Kuen Lau, Harold Lee, Kwan Hung Leung, Bonnie Kho, Howard Wong, Cheong Ngai, Yu Yan Hwang, Joycelyn Sim, Yok Lam Kwong, Chor Sang Chim
Publikováno v:
Therapeutic Advances in Hematology, Vol 13 (2022)
Introduction: Bortezomib has been reported to favourably impact the outcomes of t (4;14) and del(17p) in multiple myeloma (MM), but its impact on gain 1q (+1q) is unknown. Methods: To address this, 250 patients treated with bortezomib-based induction
Externí odkaz:
https://doaj.org/article/9e151dd4f498461cadbd594b9833c864
Publikováno v:
Therapeutic Advances in Hematology, Vol 12 (2021)
Complete response (CR) is an important favorable factor for survival in multiple myeloma (MM). However, CR patients continue to relapse, especially in the presence of minimal residual disease (MRD). Bone marrow (BM) MRD is predictive of progression-f
Externí odkaz:
https://doaj.org/article/b026b9fc3bb348f48f67b9ccca293b0c
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Here we compared clonotype identification by allele-specific oligonucleotide real-time quantitative-PCR (ASO RQ-PCR) and next-generation sequencing (NGS) in 80 multiple myeloma patients. ASO RQ-PCR was applicable in 49/55 (89%) and NGS in 62/78 (80%)
Externí odkaz:
https://doaj.org/article/d7e1321a42ff4a0c868eb821a207ba0d
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-4 (2018)
Abstract Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. Herein, promoter methylation stat
Externí odkaz:
https://doaj.org/article/37d552c1c0d04792b9a57adbab99d54c
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Next-generation sequencing (NGS) has been applied to monitor minimal residual disease (MRD) in multiple myeloma (MM). Standardized DNA input and sequencing depth is essential for achieving a uniform sensitivity in NGS-based MRD study. Herein, the sen
Externí odkaz:
https://doaj.org/article/95a5e973153148678046ecda34f8b8d5
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-3 (2016)
Abstract Allele-specific oligonucleotide real-time quantitative PCR (ASO-RQPCR) is a standardized technique for detection and monitoring of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) but not multiple myeloma (MM) due to a lo
Externí odkaz:
https://doaj.org/article/23f4677de1754b38bc4da4d58c770740
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a CpG island is present at the putative promoter region of its host gene, AATK, we postulated that the intronic miR-1250-5p is a tumor suppressor miRNA co-regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa059fd2b6cf37bb9d0cf3049b88ae21
https://doaj.org/article/61b3baf18cab4d368945422ad0e06b29
https://doaj.org/article/61b3baf18cab4d368945422ad0e06b29