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Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer.

Autor: Fang K; Data Science Institute, MCW Cancer Center and Mellowes Center for Genome Science and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Ohihoin AG; Cell and Developmental Biology PhD Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Liu T; Data Science Institute, MCW Cancer Center and Mellowes Center for Genome Science and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Choppavarapu L; Data Science Institute, MCW Cancer Center and Mellowes Center for Genome Science and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Nosirov B; Department of Cancer Research, Luxembourg Institute of Health, NORLUX Neuro-Oncology Laboratory and Multiomics Data Science Research Group, Strassen, L-1445, Luxembourg., Wang Q; Department of Pathology and Duke Cancer Institute, Duke University, Durham, NC, 27710, USA., Yu XZ; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Kamaraju S; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Leone G; Department of Pathology and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Jin VX; Data Science Institute, MCW Cancer Center and Mellowes Center for Genome Science and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. vjin@mcw.edu.

Publikováno v: Genome medicine [Genome Med] 2024 Nov 18; Vol. 16 (1), pp. 134. Date of Electronic Publication: 2024 Nov 18.

Reprogramming of 3D chromatin domains by antagonizing the β-catenin/CBP interaction attenuates insulin signaling in pancreatic cancer.

Autor: Zhou Y, Li T, He Z, Choppavarapu L, Hu X, Cao R, Leone GW, Kahn M, Jin VX

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 14. Date of Electronic Publication: 2023 Nov 14.