SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis.

Autor: Mendez Espinoza I; Department of Human Science, Georgetown University, Washington, District of Columbia, United States., Choos END; Department of Human Science, Georgetown University, Washington, District of Columbia, United States., Ecelbarger CM; Department of Medicine, Georgetown University, Washington, District of Columbia, United States., Shepard BD; Department of Human Science, Georgetown University, Washington, District of Columbia, United States.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2024 Aug 01; Vol. 327 (2), pp. G235-G253. Date of Electronic Publication: 2024 Jun 25.

Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice.

Autor: Kurtz R; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., Libby A; Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80012, USA., Jones BA; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA., Myakala K; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA., Wang X; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA., Lee Y; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA., Knoer G; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA., Lo Cascio JN; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., McCormack M; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA., Nguyen G; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., Choos END; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA., Rodriguez O; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA., Rosenberg AZ; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Ranjit S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA.; Microscopy & Imaging Shared Resources, Georgetown University Medical Center, Washington, DC 20057, USA., Albanese C; Department Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.; Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA.; Department of Radiology, Georgetown University Medical Center, Washington, DC 20057, USA., Levi M; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA., Ecelbarger CM; Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA., Shepard BD; Department of Human Science, Georgetown University Medical Center, Washington, DC 20057, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 May 18; Vol. 23 (10). Date of Electronic Publication: 2022 May 18.