β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells

Autor: Lee, Eun Joo Jung, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Choong Won Kim, Won Sup

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9867

β-lapachone (β-Lap), a topoisomerase inhibitor, is a naturally occurring ortho-naphthoquinone phytochemical and is involved in drug resistance mechanisms. Oxaliplatin (OxPt) is a commonly used chemotherapeutic drug for metastatic colorectal cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::0ba8449beb6429a06fe0b51e3aeb05d6

Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation

Autor: Eun Joo Jung, Anjugam Paramanantham, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Ky Hyun Chung, Choong Won Kim, Won Sup Lee

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1598, p 1598 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1598

The anticancer effects of natural phytochemicals are relevant to the modulation of cytokine signaling pathways in various cancer cells with stem-like properties as well as immune cells. The aim of this study was to elucidate a novel anticancer mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e4dcdbe31b98f40cafc7a558937d99
https://www.mdpi.com/1422-0067/23/3/1598

Artemisia annua L. Polyphenol-Induced Cell Death Is ROS-Independently Enhanced by Inhibition of JNK in HCT116 Colorectal Cancer Cells

Autor: Choong Won Kim, Anjugam Paramanantham, Hye Jung Kim, Jin-Myung Jung, Eun Joo Jung, Gon Sup Kim, Soon-Chan Hong, Won Sup Lee, Sung Chul Shin, Ky Hyun Chung, Chung Ho Ryu

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 1366, p 1366 (2021)
Volume 22
Issue 3

c-Jun N-terminal kinase (JNK) is activated by chemotherapeutic reagents including natural plant polyphenols, and cell fate is determined by activated phospho-JNK as survival or death depending on stimuli and cell types. The purpose of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccad30ece7fff5cef2e5a5b4717a85d
http://europepmc.org/articles/PMC7866371

p53 Enhances

Autor: Eun Joo, Jung, Won Sup, Lee, Anjugam, Paramanantham, Hye Jung, Kim, Sung Chul, Shin, Gon Sup, Kim, Jin-Myung, Jung, Chung Ho, Ryu, Soon Chan, Hong, Ky Hyun, Chung, Choong Won, Kim

Publikováno v: International Journal of Molecular Sciences

Plant-derived natural polyphenols exhibit anticancer activity without showing any noticeable toxicities to normal cells. The aim of this study was to investigate the role of p53 on the anticancer effect of polyphenols isolated from Korean Artemisia a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f562e983fa84cbfd7bdca9249a7072b0
https://pubmed.ncbi.nlm.nih.gov/33297377

Identification of simvastatin-regulated targets associated with JNK activation in DU145 human prostate cancer cell death signaling

Autor: Eun Joo Jung, Ky Hyun Chung, Choong Won Kim

Publikováno v: BMB Reports
BMB REPORTS(50): 9

The results of this study show that c-Jun N-terminal kinase (JNK) activation was associated with the enhancement of docetaxel-induced cytotoxicity by simvastatin in DU145 human prostate cancer cells. To better understand the basic molecular mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e78e585a671bef4ae8685941c2a2a5f
http://europepmc.org/articles/PMC5625694