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AKI Risk Score (AKI-RiSc): Developing an Interpretable Clinical Score for Early Identification of Acute Kidney Injury for Patients Presenting to the Emergency Department

Autor: Wah Ho Af, Choong L, Koniman R, Ang Y, Bibhas Chakraborty, Hock Ong Me, Nan Liu, Su Hooi Teo, Feng Xie

BackgroundAcute kidney injury (AKI) in hospitalised patients is a common syndrome associated with poorer patient outcomes. Clinical risk scores can be used for the early identification of patients at risk of AKI.MethodsWe conducted a retrospective st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::879d5aff2365fa62ad59cdf67d571dd2
https://doi.org/10.1101/2021.06.18.21259146

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Constrained Bithiazoles: Small Molecule Correctors of Defective ΔF508–CFTR Protein Trafficking

Autor: Choong L. Yoo, Baoxue Yang, Brandi M. Hudson, Mark J. Kurth, Gui J. Yu, Huy Nguyen, Dean J. Tantillo, Alan S. Verkman, Michael W. Lodewyk, Puay Wah Phuan, Deanna Montgomery, Alex L. Bagdasarian, Keith C. Coffman

Publikováno v: Journal of Medicinal Chemistry

Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the ΔF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41d6e8404d5899fdc52c2ea8d8d05ff
https://doi.org/10.1021/jm5007885

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Akademický článek

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Akademický článek

KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane

Autor: Kuen Kuen Lam, Yee Syuen Low, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile Tan, Aik Yong Chok, Isaac Seow-En, Siew Heng Wong, Peh Yean Cheah

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

Colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality worldwide. To date, chemotherapeutic treatment of advanced CRC that has metastasized has a dismayed success rate of less than 30%. Further, most (80

Externí odkaz: https://doaj.org/article/81b1cebe13f34c0d82560ad6fed3b289

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Akademický článek

KRAS mutation‐independent downregulation of MAPK/PI3K signaling in colorectal cancer

Autor: Kuen Kuen Lam, Choong Leong Tang, Emile Tan, Siew Heng Wong, Peh Yean Cheah

Publikováno v: Molecular Oncology, Vol 16, Iss 5, Pp 1171-1183 (2022)

KRAS is a gatekeeper gene in human colorectal tumorigenesis. KRAS is ‘undruggable’; hence, efforts have been diverted to inhibit downstream RAF/MEK/ERK and PI3K/Akt signaling. Nevertheless, none of these inhibitors has progressed to clinical use

Externí odkaz: https://doaj.org/article/9a6cf8a0a2734ec799f79027954a5b05

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Self-Reported Medication Adherence Among Patients with Ulcerative Colitis in Japan and the United Kingdom: A Secondary Analysis for Cross-Cultural Comparison

Autor: Kawakami A, Tanaka M, Choong LM, Kunisaki R, Maeda S, Bjarnason I, Hayee B

Publikováno v: Patient Preference and Adherence, Vol Volume 16, Pp 671-678 (2022)

Aki Kawakami,1,2 Makoto Tanaka,2 Lee Meng Choong,1 Reiko Kunisaki,3 Shin Maeda,4 Ingvar Bjarnason,1 Bu’Hussain Hayee1 1Department of Gastroenterology, King’s College Hospital, London, UK; 2Department of Critical and Invasive-Palliative Care Nursi

Externí odkaz: https://doaj.org/article/4319daac131c45fe9259f1ff26a1c66e

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Akademický článek

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Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles

Autor: Thomas C. Sparks, Lorsbach Beth, Kristin A. Milinkevich, Mark J. Kurth, Choong L. Yoo

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:5796-5798

Acid hydrazides were coupled with acrylic acid derivatives and cyclodehydration gave 1,3,4-oxadiazoles. Lastly, in-situ nitrile oxide formation from aryl oximes treated with sodium hypochlorite, and subsequent 1,3-dipolar cycloaddition to the exometh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd549898189577f64050921fa87c7868
https://doi.org/10.1016/j.bmcl.2009.07.139

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Solitary Plasmacytoma of Bone: An Unusual Cause of Severe Sacral Pain in a Young Man

Autor: Choong L. Wong, Robert Mansberg

Publikováno v: Clinical Nuclear Medicine. 30:612-614

A 35-year-old man presented with insidious onset of severe sacral pain. Plain radiography, computed tomography, and magnetic resonance imaging revealed a large, locally invasive mass within the sacrum. Skeletal scintigraphy showed marked hyperemia an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbba294df843e39417593f883f644d84
https://doi.org/10.1097/01.rlu.0000174234.70583.13

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