Dengue virus activates cGAS through the release of mitochondrial DNA

Autor: Bo Sun, Karin B. Sundström, Jun Jie Chew, Pradeep Bist, Esther S. Gan, Hwee Cheng Tan, Kenneth C. Goh, Tanu Chawla, Choon Kit Tang, Eng Eong Ooi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)

Abstract Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting po

Externí odkaz: https://doaj.org/article/b41daa6c581143b7a27dd423f55e72bf

Dengue virus activates cGAS through the release of mitochondrial DNA

Autor: Jun Jie Chew, Kenneth C. Goh, Tanu Chawla, Hwee Cheng Tan, Pradeep Bist, Bo Sun, Choon Kit Tang, Eng Eong Ooi, Esther S. Gan, Karin B. Sundstrom

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports

Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting positive-se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f45c7181d2d67b02f8f21fdc74815d
https://doaj.org/article/b41daa6c581143b7a27dd423f55e72bf

Molecular determinants of plaque size as an indicator of dengue virus attenuation

Autor: Choon Kit Tang, Andrew D. Davidson, Kenneth C. Goh, Ashley L. St. John, Duane J. Gubler, Hwee Cheng Tan, October M. Sessions, Diana Norton, Yin Bun Cheung, Xin Mei Ong, Uma S. Kamaraj, Eng Eong Ooi, Bo Sun, Ayesa Syenina, Amjad Yousuf, Esther S. Gan

Publikováno v: Goh, K C M, Tang, C K, Norton, D, Gan, E S, Tan, H C, Sun, B, Syenina, A, Yousuf, A, Ong, X M, Kamaraj, U S, Cheung, Y B, Gubler, D J, Davidson, A, St John, A L, Sessions, O M & Ooi, E E 2016, ' Molecular determinants of plaque size as an indicator of dengue virus attenuation ', Scientific Reports, vol. 6, 26100 . https://doi.org/10.1038/srep26100
Scientific Reports

The development of live viral vaccines relies on empirically derived phenotypic criteria, especially small plaque sizes, to indicate attenuation. However, while some candidate vaccines successfully translated into licensed applications, others have f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b912dd57764a85f8f37b4f5109d78be1
https://research-information.bris.ac.uk/en/publications/cd168f74-5b6f-488b-acf6-57791253e69c

Mixed Vector Immunization With Recombinant Adenovirus and MVA Can Improve Vaccine Efficacy While Decreasing Antivector Immunity

Autor: Karolis Bauza, Adrian V. S. Hill, Matthew D. J. Dicks, Anita Milicic, Arturo Reyes-Sandoval, Christine S. Rollier, Choon-Kit Tang, David H. Wyllie, Rhea J. Longley, Dong Wang, Matthew G. Cottingham

Publikováno v: Molecular Therapy

Substantial protection can be provided against the pre-erythrocytic stages of malaria by vaccination first with an adenoviral and then with an modified vaccinia virus Ankara (MVA) poxviral vector encoding the same ME.TRAP transgene. We investigated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0911e9908c9edef609bf97e12447935c
https://doi.org/10.1038/mt.2012.25

Intracellular detection and immune signaling pathways of DNA vaccines

Autor: Choon-Kit Tang, Geoffrey A. Pietersz

Publikováno v: Expert Review of Vaccines. 8:1161-1170

Parallel to attenuated and subunit vaccines, DNA vaccines require adjuvant signals in addition to antigen presentation for the induction of adaptive immune responses. As opposed to common beliefs, increasing evidence is showing that Toll-like recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e410239781d07e3438b98a65a12b6b00
https://doi.org/10.1586/erv.09.79