Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Choon Hong Tan"'
Publikováno v:
FEBS Open Bio, Vol 14, Iss 7, Pp 1057-1071 (2024)
There has been renewed interest in using mitochondrial uncoupler compounds such as niclosamide and carbonyl cyanide p‐(trifluoromethoxy)phenylhydrazone (FCCP) for the treatment of obesity, hepatosteatosis and diseases where oxidative stress plays a
Externí odkaz:
https://doaj.org/article/e1952b0b5d03465797688ea67c60bdfd
Autor:
Mei Ying Ng, Zhi Jian Song, Gopalakrishnan Venkatesan, Sergio Rodriguez-Cuenca, James A. West, Shili Yang, Choon Hong Tan, Paul Chi-Lui Ho, Julian L. Griffin, Antonio Vidal-Puig, Marcella Bassetto, Thilo Hagen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract One potential approach for treating obesity is to increase energy expenditure in brown and white adipose tissue. Here we aimed to achieve this outcome by targeting mitochondrial uncoupler compounds selectively to adipose tissue, thus avoidin
Externí odkaz:
https://doaj.org/article/1cb8ab98e74f4ee794d196ce80370f84
Autor:
Choon Hong Tan, Hawa Rahmat, Wei Fern Siew, Alexius Weng Onn Cheang, Ah Choo Koo, Elyna Amir Sharji
Publikováno v:
F1000Research, Vol 11 (2022)
Background: eHealth makes use of information and communication technologies (ICT) to improve health. In the digital age, the use of eHealth applications and other health-related applications has gained popularity, particularly during the COVID-19 pan
Externí odkaz:
https://doaj.org/article/73e6b681bc0641e398c8c2fda04a16e2
Autor:
July Fong, Kim T. Mortensen, Amalie Nørskov, Katrine Qvortrup, Liang Yang, Choon Hong Tan, Thomas E. Nielsen, Michael Givskov
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2019)
Pseudomonas aeruginosa is known as an opportunistic pathogen that often causes persistent infections associated with high level of antibiotic-resistance and biofilms formation. Chemical interference with bacterial cell-to-cell communication, termed q
Externí odkaz:
https://doaj.org/article/bc1d1d7b987144d1a00125b26f3fe487
Autor:
Wentao Wu, Esther Cai Xia Ang, Xinru Xu, Qi Wang, Hong Wang, Richmond Lee, Choon-Hong Tan, Xinyi Ye
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract N-oxides play a pivotal role in natural products and emerging drug design, while also serving as valuable ligand scaffolds in organometallic chemistry. Among heteroatom oxidations, the conversion of amines to N-oxides is a critical and chall
Externí odkaz:
https://doaj.org/article/158bfaea71ac4792b0bfdb931bd304b4
Autor:
Qiaoqiang Li, Yuqing Dai, Xinru Xu, Wentao Wu, Wenchao Chen, Hong Wang, Choon-Hong Tan, Xinyi Ye
Publikováno v:
Organic Letters; 7/26/2024, Vol. 26 Issue 29, p6241-6246, 6p
Publikováno v:
Green Synthesis and Catalysis, Vol 2, Iss 1, Pp 6-18 (2021)
The construction of chiral phosphorus molecules with asymmetric center on the phosphorus atom has always been considered to be challenging in synthetic chemistry. Such P-stereogenic compounds possess many unique properties allowing many potential app
Externí odkaz:
https://doaj.org/article/6787178495914df589849dd9e57df56e
Autor:
Yuheng Zhang, Haimeng Zhu, Boyuan Zhang, Huijuan Yang, Choon-Hong Tan, Chao Wang, Jin Wen, Lili Zong
Publikováno v:
ACS Catalysis. 13:7103-7109
Autor:
Mingjun Yuan, Song Lin Chua, Yang Liu, Daniela I. Drautz-Moses, Joey Kuok Hoong Yam, Thet Tun Aung, Roger W. Beuerman, May Margarette Santillan Salido, Stephan C. Schuster, Choon-Hong Tan, Michael Givskov, Liang Yang, Thomas E. Nielsen
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 3059-3069 (2018)
Antibiotic resistance threatens effective treatment of microbial infections globally. This situation has spurred the hunt for new antimicrobial compounds in both academia and the pharmaceutical industry. Here, we report how the widely used antitumor
Externí odkaz:
https://doaj.org/article/753a8d0395f842239fb8a40c6d273c36
Publikováno v:
JACS Au. 3:700-714
Sulfur can form diverse S(IV) and S(VI) stereogenic centers, of which some have gained significant attention recently due to their increasing use as pharmacophores in drug discovery programs. The preparation of these sulfur stereogenic centers in the