Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chongzhuang Tang"'
Autor:
Xinyu Ge, Sheng Ma, Shu Yan, Yali Wu, Chong Chen, Chongzhuang Tang, Yan Zhan, Yi-cong Bian, Kai Shen, Sheng Feng, Xuehu Gao, Dafang Zhong, Hua Zhang, Li-yan Miao, Xing-xing Diao
Publikováno v:
Xenobiotica. 53:69-83
Publikováno v:
Current Drug Metabolism. 22:870-881
Background: The hepatotoxic pyrrolizidine alkaloids (PAs) were reported to increase bile acid (BA) levels in the rat. However, it is still unclear whether the production of highly reactive dehydropyrrolizidine through CYP450s is directly relevant to
Publikováno v:
Drug Metabolism and Disposition. 49:434-441
Disulfiram, an antialcoholism drug, could potentially be repurposed as an anticancer drug because of the formation of copper(II) diethyldithiocarbamate (CuET) from dithiocarb (DTC, a reduced metabolite of disulfiram) and Cu2+. CuET exhibited preferen
Publikováno v:
Current Drug Metabolism. 21:1040-1051
Background: Retrorsine is one of the hepatotoxic pyrrolizidine alkaloids, which could be converted into a highly reactive metabolite, dehydroretrorsine, by CYP3A, and to a lesser extent by CYP2C and CYP2B. Objective: We employed Cyp3a knockout (3AKO)
Publikováno v:
Pharmacology & Therapeutics. 233:108020
Oxidative metabolism is one of the major biotransformation reactions that regulates the exposure of xenobiotics and their metabolites in the circulatory system and local tissues and organs, and influences their efficacy and toxicity. Although cytochr
Publikováno v:
Biomedical Chromatography. 34
From the point of view of drug efficacy and safety, pharmacokinetic profiles of both In this work, a sensitive and reliable liquid chromatographic-tandem mass spectrometric method was established for simultaneous determination of sutetinib and N-oxid
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(6)
Racemic proton pump inhibitors (PPIs) have been developed into pure enantiomers given superior pharmacokinetic profiles. However, after doses of single enantiomer PPIs, different degrees of chiral inversion were observed. We investigated the relation
Autor:
Liang Li, Bo Chen, Xifeng Ma, Xiaojian Dai, Chongzhuang Tang, Yifan Zhang, Jin Wang, Xiaoyan Chen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 183:113146
Anaprazole is a novel proton pump inhibitor under development for the treatment of gastric and duodenal ulcers. In the present study, an ultra-performance liquid chromatography-ultraviolet detector/quadrupole time-of-flight mass spectrometry method w