Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Chongzhen Yuan"'
Autor:
Farida El Gaamouch, Hsiao-yun Lin, Qian Wang, Wei Zhao, Jiangping Pan, Kalena Liu, Jean Wong, Clark Wu, Chongzhen Yuan, Haoxiang Cheng, Weiping Qin, Ke Hao, Bin Zhang, Jun Wang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population. In this study, we explore the effect of high
Externí odkaz:
https://doaj.org/article/54a39f6f1c824a2b8a526cfa49487755
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer′s disease (AD) is an irreversible progressive neurodegenerative disease affecting approximately 50 million people worldwide. It is estimated to reach 152 million by the year 2050. AD is the fifth leading cause of death among Americans age
Externí odkaz:
https://doaj.org/article/b66407b0ac2e448085e79b8d9d67fc2e
Autor:
Farida El Gaamouch, Hsiao-yun Lin, Qian Wang, Wei Zhao, Jiangping Pan, Kalena Liu, Jean Wong, Clark Wu, Chongzhen Yuan, Haoxiang Cheng, Weiping Qin, Ke Hao, Bin Zhang, Jun Wang
Publikováno v:
Scientific reports. 12(1)
Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population. In this study, we explore the effect of high fat diet
Autor:
El Gaamouch, Farida, Chen, Fiona, Lap Ho, Hsiao-Yun Lin, Chongzhen Yuan, Wong, Jean, Jun Wang
Publikováno v:
Frontiers in Aging Neuroscience; 12/13/2022, Vol. 14, p01-11, 11p
Autor:
Long Li, Romain Durand-de Cuttoli, Antonio V. Aubry, C. Joseph Burnett, Flurin Cathomas, Lyonna F. Parise, Kenny L. Chan, Carole Morel, Chongzhen Yuan, Yusuke Shimo, Hsiao-yun Lin, Jun Wang, Scott J. Russo
Publikováno v:
Nature.
In humans, traumatic social experiences can contribute to psychiatric disorders1. It is suggested that social trauma impairs brain reward function such that social behaviour is no longer rewarding, leading to severe social avoidance2,3. In rodents, t
Autor:
Hong Zhang, Keyu Chen, Mingjie Zhang, Jianchao Li, Ruichi Zhu, Hui Zheng, Hongyu Zhao, Chao Wang, Chongzhen Yuan
Publikováno v:
Nature Chemical Biology. 14:778-787
The mammalian Atg8 family proteins are central drivers of autophagy and contain six members, classified into the LC3 and GABARAP subfamilies. Due to their high sequence similarity and consequent functional overlaps, it is difficult to delineate speci
Publikováno v:
Autophagy
Genetic screens have identified two sets of genes that act at distinct steps of basal autophagy in higher eukaryotes: the pan-eukaryotic ATG genes and the metazoan-specific EPG genes. Very little is known about whether these core macroautophagy/autop
Autor:
Xiaochen Wang, Chongzhen Yuan, Hong Zhang, Dongfeng Zhao, Yanan Sun, Zhaoyu Wang, Hongyu Zhao
Publikováno v:
Journal of cell science. 132(19)
Vici syndrome is a severe and progressive multisystem disease caused by mutations in the EPG5 gene. In patient tissues and animal models, loss of EPG5 function is associated with defective autophagy caused by accumulation of non-degradative autolysos
Autor:
Xue Xue, Xiangyang Guo, Zhaoyu Wang, Hong Zhang, Zheng Wang, Gangming Zhang, Yingyu Chen, Junjie Hu, Du Feng, Guangyan Miao, Chongzhen Yuan
Publikováno v:
Molecular Cell. 63:781-795
Mutations in the human autophagy gene EPG5 cause the multisystem disorder Vici syndrome. Here we demonstrated that EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. EPG5 is recruited to la
Publikováno v:
Molecular Medicine Reports
XRCC4-like factor (XLF) is involved in non-homologous end joining-mediated repair of DNA double-strand breaks (DSBs). Mutations in the WRN gene results in the development of Werner syndrome (WS), a rare autosomal recessive disorder characterized by p