Výsledky vyhledávání - "Chongkun Shen"

Akademický článek

Network pharmacology- and molecular docking-based investigation on the mechanism of action of Si-ni San in the treatment of depression combined with anxiety and experimental verification in adolescent rats

Autor: Zhiping Li, Shimin Liang, Xulan Cui, Chongkun Shen, Zaibin Xu, Wei Chen, Mingan Wu, Chao Liang, Jinman Liu, Jiawen Huang, Weirong Li

Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)

BackgroundThe incidence rate of adolescent depression and anxiety has been increasing since the outbreak of COVID-19, which there are no effective therapeutic drugs available. Si-ni San is commonly used in traditional Chinese medicine for the treatme

Externí odkaz: https://doaj.org/article/15e7c41005874c72b8fb46a1f77c2748

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Akademický článek

The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

Autor: Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong Li

Publikováno v: Frontiers in Psychiatry, Vol 12 (2021)

Our aims were to evaluate the depression model of early maternal separation (MS) combined with adolescent chronic unpredictable mild stress (CUMS) in female adult SD rats to observe the behavior and the expressions of synaptic proteins in rats and to

Externí odkaz: https://doaj.org/article/6af22f880ac54aa7acd111e47a16abd7

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Akademický článek

SiNiSan ameliorates depression-like behavior in rats by enhancing synaptic plasticity via the CaSR-PKC-ERK signaling pathway

Autor: Chongkun Shen, Kerun Cao, Sainan Cui, Yongfei Cui, Haixin Mo, Wenhao Wen, Zhaoyang Dong, Huiyuan Lin, Shasha Bai, Lei Yang, Rong Zhang, Yafei Shi

Publikováno v: Biomedicine & Pharmacotherapy, Vol 124, Iss , Pp 109787- (2020)

Background: Adverse stress in early life negatively influences psychiatric health by increasing the risk of developing depression and suicide in adulthood. Clinical antidepressants, such as fluoxetine, exhibit unsatisfactory results due to their low

Externí odkaz: https://doaj.org/article/cd97a34a012848f0aef45a0007d64df6

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Akademický článek

Early-Life Stress Induces Depression-Like Behavior and Synaptic-Plasticity Changes in a Maternal Separation Rat Model: Gender Difference and Metabolomics Study

Autor: Yongfei Cui, Kerun Cao, Huiyuan Lin, Sainan Cui, Chongkun Shen, Wenhao Wen, Haixin Mo, Zhaoyang Dong, Shasha Bai, Lei Yang, Yafei Shi, Rong Zhang

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

More than 300 million people suffer from depressive disorders globally. People under early-life stress (ELS) are reportedly vulnerable to depression in their adulthood, and synaptic plasticity can be the molecular mechanism underlying such depression

Externí odkaz: https://doaj.org/article/bb981e5198474b5e8fcd569ae4267fe5

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Akademický článek

SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway

Autor: Kerun Cao, Chongkun Shen, Yumei Yuan, Shasha Bai, Lei Yang, Lili Guo, Rong Zhang, Yafei Shi

Publikováno v: Frontiers in Psychiatry, Vol 10 (2019)

Background: Early adverse life stress is an important dangerous factor in the development of psychiatric disorders, particularly depression. Available clinical antidepressant agents, such as fluoxetine, [a selective serotonin reuptake inhibitor (SSRI

Externí odkaz: https://doaj.org/article/40f096e104834de7bbced0e0d2722092

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Stress causes cognitive impairment by affecting cholesterol efflux and reuptake leading to abnormalities in lipid metabolism of rats

Autor: Miao Zhang, Lei Yang, Rong Zhang, Zhangyu Jiang, Qiang Cai, Yafei Shi, Shasha Bai, Song Zhang, Chongkun Shen, Kerun Cao, Ran Ye

Publikováno v: Journal of Integrative Neuroscience, Vol 19, Iss 1, Pp 39-49 (2020)

Depression is a common mental health disorder that can impair normal functions, cause distress, and adversely affect the quality of life. Cognitive impairment is considered one of the characteristics of major depression disorders-related dysfunction,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d998f60ac52e70b67d70266b2f9f7e2
https://jin.imrpress.com/fileup/1757-448X/PDF/1585708660932-732311879.pdf

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Depression promotes lung carcinoma progression by regulating the tumor microenvironment in tumor-bearing models of C57BL/6J mice

Autor: Rong Zhang, Yafei Shi, Yongfei Cui, Sainan Cui, Shasha Bai, Haixin Mo, Huiyuan Lin, Chongkun Shen, Wenhao Wen, Lei Yang, Xulan Cui

Publikováno v: Neuroscience letters. 754

Psychological stress is a common etiology among patients with lung cancer and serves as a potential indication of poor prognosis and advanced cancer clinical stage. Evidence indicates that depression is positively correlated with the evolvement of lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b828b68a2e5b2bf5a69cde485c4ceea
https://pubmed.ncbi.nlm.nih.gov/33781910

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SiNiSan ameliorates depression-like behavior in rats by enhancing synaptic plasticity via the CaSR-PKC-ERK signaling pathway

Autor: Rong Zhang, Lei Yang, Sainan Cui, Yafei Shi, Zhaoyang Dong, Wenhao Wen, Yongfei Cui, Kerun Cao, Huiyuan Lin, Shasha Bai, Haixin Mo, Chongkun Shen

Publikováno v: Biomedicine & Pharmacotherapy, Vol 124, Iss, Pp 109787-(2020)

Background Adverse stress in early life negatively influences psychiatric health by increasing the risk of developing depression and suicide in adulthood. Clinical antidepressants, such as fluoxetine, exhibit unsatisfactory results due to their low e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1462fb717aa7ecd524cd828ca19cfae6
http://www.sciencedirect.com/science/article/pii/S0753332219354095

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