Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Chong-Xu Fan"'
1
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus
Autor: Jia Li, Chong-Xu Fan, Yanping Li, Chao Bian, Xinxin You, Xueqiang Lin, Ruobo Gu, Yunyun Lv, Bingmiao Gao, Jiaan Yang, Ji-Sheng Chen, Kai Zhang, Qiong Shi, Chao Peng, Junmin Xu, Jieming Chen, Yanbin He, Ge Yao, Hui Jiang, Jie Liu, Xinhui Zhang, Zhiqiang Ruan, Yu Huang, Lin Zhilong, Yunhai Yi
Publikováno v: Cell Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Discovery
Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C. betulinus) as a representative, we sequenced and assembled the firs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ceadd5f9b5d8760e3edc795606acb3
https://doaj.org/article/e0a00a926885480ebe015ba142f251c0
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2
Contryphan-Bt: A pyroglutamic acid containing conopeptide isolated from the venom of Conus betulinus
Autor: Ying Cao, Shang-Yi Liu, Ge Yao, Chong-Xu Fan, Xiandong Dai, Wenjian Wu, Penggang Han, Ji-Sheng Chen
Publikováno v: Toxicon. 135:17-23
A new member of the contryphans family was isolated from the venom of Conus betilinus, a vermivorous species distributed in the South China Sea. Its sequence, ZSGCO(D-W)KPWC-NH 2 (Z, pyroglutamic acid), was established by a combination of de novo MS/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba706152d7b39e29aac31b685fadbda6
https://doi.org/10.1016/j.toxicon.2017.05.022
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3
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing
Autor: Qiong Shi, Ying Cao, Chao Peng, Ji-Sheng Chen, Chong-Xu Fan, Hui Jiang, Ge Yao, Yabing Zhu
Publikováno v: Marine Drugs, Vol 17, Iss 3, p 193 (2019)
Marine Drugs
Volume 17
Issue 3
The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f09d8c84b4fbb414856451e8dee06c
https://www.mdpi.com/1660-3397/17/3/193
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6
The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4
Autor: Shang-Yi Liu, Chong-Xu Fan, Kang Wang, Wenjian Wu, Ying Cao, Xiandong Dai, Penggang Han, Hui Jiang, Ji-Sheng Chen
Publikováno v: Marine Drugs, Vol 14, Iss 11, p 213 (2016)
Marine Drugs; Volume 14; Issue 11; Pages: 213
μ-Conotoxin GIIIA, a peptide toxin isolated from Conus geographus, preferentially blocks the skeletal muscle sodium channel NaV1.4. GIIIA folds compactly to a pyramidal structure stabilized by three disulfide bonds. To assess the contributions of in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1337bb88c63c45ffdb54d80598da373d
http://www.mdpi.com/1660-3397/14/11/213
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7
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing
Autor: Jie Bai, Ge Yao, Xinxin You, Ji-Sheng Chen, Jintu Wang, Qiong Shi, Ying Cao, Chao Bian, Jia Li, Steven L. Coon, Shijie Zou, Yabing Zhu, Zhiqiang Ruan, Chao Peng, Jiaan Yang, Bingmiao Gao, Bo Wen, Chong-Xu Fan, Xiaofei Zhao, Ying Qiu, Zhilong Lin, Xinhui Zhang, Jieming Chen
Publikováno v: GigaScience
Background The venom of predatory marine cone snails mainly contains a diverse array of unique bioactive peptides commonly referred to as conopeptides or conotoxins. These peptides have proven to be valuable pharmacological probes and potential drugs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff997bfce688c256146719c23e5b517
https://doi.org/10.1186/s13742-016-0122-9
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9
A novel M-superfamily conotoxin with a unique motif from Conus vexillum
Autor: Hui Jiang, Ji-Sheng Chen, Cheng-Zhong Wang, Cheng-Wu Chi, Chong-Xu Fan, Chenqi Xu, Xiandong Dai
Publikováno v: Peptides. 27:682-689
Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds for the purpose of feeding and defence, each evolved to act in a highly specific manner on different parts of the nervous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432dcb998d46dd25253bfc17ddc11e46
https://doi.org/10.1016/j.peptides.2005.08.004
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10
A Novel Conotoxin from Conus betulinus, κ-BtX, Unique in Cysteine Pattern and in Function as a Specific BK Channel Modulator
Autor: Chen Zhang, Xiao-Ke Chen, Ying Cao, Ming-Nai Zhong, Lin-Lin He, Kai-Lai Duan, Zhuan Zhou, Cheng-Wu Chi, Shang-Yi Liu, Jan Tytgat, Li-Xiu Wang, Chong-Xu Fan, Chris Ulens, Ji-Sheng Chen
Publikováno v: Journal of Biological Chemistry. 278:12624-12633
A novel conotoxin, kappa-conotoxin (kappa-BtX), has been purified and characterized from the venom of a worm-hunting cone snail, Conus betulinus. The toxin, with four disulfide bonds, shares no sequence homology with any other conotoxins. Based on a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144b13d5d6d1d1bdb7e1f93644848a08
https://doi.org/10.1074/jbc.m210200200
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