Zobrazeno 1 - 10
of 4 855
pro vyhledávání: '"Chong Y."'
Autor:
Jiehan Li, Christopher Jin, Stefan Gustafsson, Abhiram Rao, Martin Wabitsch, Chong Y. Park, Thomas Quertermous, Joshua W. Knowles, Ewa Bielczyk-Maczynska
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-10 (2023)
Abstract Adipogenesis is a process in which fat-specific progenitor cells (preadipocytes) differentiate into adipocytes that carry out the key metabolic functions of the adipose tissue, including glucose uptake, energy storage, and adipokine secretio
Externí odkaz:
https://doaj.org/article/0a722d0cb0694bfa8551d9ed0044cc3d
Autor:
Nour Elkhateeb, Sarah Hyde, Sarah L. Hogg, Daniel Allsop, Arun Shankar, Patrick Deegan, Chong Y. Tan
Publikováno v:
JIMD Reports, Vol 64, Iss 3, Pp 238-245 (2023)
Abstract Classical homocystinuria (HCU) is caused by cystathionine β‐synthase deficiency leading to impaired homocysteine transsulfuration and accumulation of homocysteine and methionine. Patients present with a wide spectrum of manifestations inc
Externí odkaz:
https://doaj.org/article/d8483ff8492747449f659891716e346e
Autor:
Ewa Bielczyk-Maczynska, Meng Zhao, Peter-James H. Zushin, Theresia M. Schnurr, Hyun-Jung Kim, Jiehan Li, Pratima Nallagatla, Panjamaporn Sangwung, Chong Y. Park, Cameron Cornn, Andreas Stahl, Katrin J. Svensson, Joshua W. Knowles
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Rare variants in the G-protein coupled receptor 151 (GPR151) gene in humans are associated with lower odds ratio for type 2 diabetes, but the mechanism behind this association has remained elusive. Here, the authors show that GPR151 regulates the pro
Externí odkaz:
https://doaj.org/article/7da455b1ee0c4c06b9aef46bc756c01c
Autor:
Simona D’Amore, Kathleen Page, Aimée Donald, Khadijeh Taiyari, Brian Tom, Patrick Deegan, Chong Y. Tan, Kenneth Poole, Simon A. Jones, Atul Mehta, Derralynn Hughes, Reena Sharma, Robin H. Lachmann, Anupam Chakrapani, Tarekegn Geberhiwot, Saikat Santra, Siddarth Banka, Timothy M. Cox, the MRC GAUCHERITE Consortium
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-22 (2021)
Abstract Background The Gaucher Investigative Therapy Evaluation is a national clinical cohort of 250 patients aged 5–87 years with Gaucher disease in the United Kingdom—an ultra-rare genetic disorder. To inform clinical decision-making and impro
Externí odkaz:
https://doaj.org/article/2d16bd7af15d425fa25f19e95c76a8ad
Autor:
Aimee Donald, Chong Y. Tan, Anupam Chakrapani, Derralyn A. Hughes, Reena Sharma, Duncan Cole, Stanislav Bardins, Martin Gorges, Simon A. Jones, Erich Schneider
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-12 (2020)
Abstract Background Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy. Systemic manifestations of disease ar
Externí odkaz:
https://doaj.org/article/3f8f71dec2714dcc9f882df4b03a3181
Autor:
Banerjee, Rimi, Mandal, Subhaskar, Terh, Yun Yong, Lin, Shuxin, Liu, Gui-Geng, Zhang, Baile, Chong, Y. D.
We show that a non-Hermitian lattice with a disclination can host topological disclination states that are induced by on-site gain and loss. The disclination states are inherently non-Hermitian as they do not exist in the limit of zero gain/loss. The
Externí odkaz:
http://arxiv.org/abs/2406.03455
Among the most intriguing features of non-Hermitian (NH) systems is the ability of complex energies to form braids under parametric variation. Several braiding behaviors, including link and knot formation, have been observed in experiments on synthet
Externí odkaz:
http://arxiv.org/abs/2406.00726
Autor:
Yosuke Tanigawa, Jiehan Li, Johanne M. Justesen, Heiko Horn, Matthew Aguirre, Christopher DeBoever, Chris Chang, Balasubramanian Narasimhan, Kasper Lage, Trevor Hastie, Chong Y. Park, Gill Bejerano, Erik Ingelsson, Manuel A. Rivas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
While many pleiotropic genetic loci have been identified, how they contribute to phenotypes across traits and diseases is unclear. Here, the authors propose decomposition of genetic associations (DeGAs), which uses singular value decomposition, to ch
Externí odkaz:
https://doaj.org/article/444dcf6d4db4447e90c469502f9a36e5
Autor:
Yu, Letian, Xue, Haoran, Guo, Ruixiang, Chan, Eng Aik, Terh, Yun Yong, Soci, Cesare, Zhang, Baile, Chong, Y. D.
Mass is commonly regarded as an intrinsic property of matter, but modern physics reveals particle masses to have complex origins, such as the Higgs mechanism in high-energy physics. In crystal lattices such as graphene, relativistic Dirac particles c
Externí odkaz:
http://arxiv.org/abs/2401.15528
We study a non-Hermitian variant of the (2+1)-dimensional Dirac wave equation, which hosts a real energy spectrum with pairwise-orthogonal eigenstates. In the spatially uniform case, the Hamiltonian's non-Hermitian symmetries allow its eigenstates to
Externí odkaz:
http://arxiv.org/abs/2304.10757