Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Chong Ock Lee"'
Autor:
Minsung Kim, Suhkneung Pyo, Chung Hyo Kang, Chong Ock Lee, Heung Kyoung Lee, Sang Un Choi, Chi Hoon Park
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198347 (2018)
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1) is overexpressed on the cell surfa
Externí odkaz:
https://doaj.org/article/9ea7f921dc354f5faa19662885bab7d9
Autor:
Heung Kyoung Lee, Ara Go, Jong Yeon Hwang, Sung Goo Park, Young Uk Jeon, Jae Du Ha, Sung Yun Cho, Chi Hoon Park, Pilho Kim, Sun Jun Park, Ji-Eun Kim, Jeong Hoon Kim, Seung-Hyun Jo, Byoung Chul Park, Chong-Ock Lee, Sung Ah Kim, Sunhong Kim
Publikováno v:
European Journal of Medicinal Chemistry. 166:65-74
Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon (CRBN) and subsequently degrading IKZF1/3. Recently, their ability to recruit E3 ubiquitin ligase has been used in the proteolysis targeting chimera (PROTAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1926b61f0b5589af19191e24dea31c1f
https://doi.org/10.1016/j.ejmech.2019.01.023
https://doi.org/10.1016/j.ejmech.2019.01.023
Autor:
Ji-Eun Kim, Chong Ock Lee, Young Hun Kim, Yeongrin Kim, Kwan-Young Jung, Miyoun Yoo, Chi Hoon Park, Sang Un Choi, Heung Kyoung Lee, Min Sung Kim, Minjin Yoo
Publikováno v:
Oncology Letters
Since bromodomain containing 4 (brd4) has been considered as a prominent cancer target, numerous attempts have been made to develop potent brd4 bromodomain inhibitors. The present study provided a novel chemical scaffold which inhibited brd4 activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68bf0638afe151f704eca3e256f84eb
https://doi.org/10.3892/ol.2021.12734
https://doi.org/10.3892/ol.2021.12734
Autor:
Chong Ock Lee, Akshay. D. Takwale, Jeong Hoon Kim, Seung-Hyun Jo, Hyung-Soo Kim, Sunjoo Ahn, Jae Du Ha, Jong Yeon Hwang, Choong Hoon Shin, Yeong Uk Jeon, Heung Kyoung Lee
Publikováno v:
European journal of medicinal chemistry. 208
Proteolysis-targeting chimera (PROTAC)-mediated protein degradation is a rapidly emerging therapeutic intervention that induces the degradation of targeted proteins. Herein, we report the design and biological evaluation of a series of androgen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3be12fd913cfdfcdff9d3d08c755cca
https://pubmed.ncbi.nlm.nih.gov/32961381
https://pubmed.ncbi.nlm.nih.gov/32961381
Publikováno v:
Biochemical and Biophysical Research Communications. 505:542-547
Recently, proteolysis targeting chimera (PROTAC) technology is highlighted in drug discovery area as a new therapeutic approach. PROTAC as a heterobifunctional molecule is comprised of two ligands, which recruit target protein and E3 ligase, respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c158f5e3d87fc5196daa918444bd6a9
https://doi.org/10.1016/j.bbrc.2018.09.169
https://doi.org/10.1016/j.bbrc.2018.09.169
Autor:
Chong Ock Lee, Sung Woong Moon, Heung Kyoung Lee, Chul Woong Chung, Sang Un Choi, Minjin Yoo, Young Hun Kim, Minsung Kim, Miyoun Yoo, Hye Kyung Chang, Chi Hoon Park, Ji-Eun Kim, Suhkneung Pyo, Kwan-Young Jung, Jung-Nyoung Heo, Chang-Soo Yun
Publikováno v:
Biochemical and Biophysical Research Communications. 503:882-887
Bromodomain-containing protein 4 (Brd4) is known to play a key role in tumorigenesis. It binds acetylated histones to regulate the expression of numerous genes. Because of the importance of brd4 in tumorigenesis, much research has been undertaken to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36e94d2e06ef81c94be197122569424
https://doi.org/10.1016/j.bbrc.2018.06.091
https://doi.org/10.1016/j.bbrc.2018.06.091
Autor:
Seung-Tae Kang, Chong Ock Lee, Byung Jin Byun, Sung Yun Cho, Hyoung Rae Kim, Hee Jung Jung, Chang-Soo Yun, Jae Du Ha, Do Hyun Ryu, Chi Hoon Park, Eun Young Kim, Jong Yeon Hwang
Publikováno v:
Archives of Pharmacal Research. 39:453-464
A series of pyridazin-3-one substituted with morpholino-pyrimidine derivatives was synthesized and evaluated as tyrosine kinase inhibitors against c-Met enzyme, and anti-proliferative activities of Hs746T human gastric cancer cell line. Most of compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f651e8f14746e27bf155c9a13ee3e85a
https://doi.org/10.1007/s12272-015-0703-7
https://doi.org/10.1007/s12272-015-0703-7
Autor:
Chong Ock Lee, Heung Kyoung Lee, Minsung Kim, Sang Un Choi, Chi Hoon Park, Chung Hyo Kang, Suhkneung Pyo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198347 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198347 (2018)
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1) is overexpressed on the cell surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2719d65fc0eeb8afd451ef1b5f2aac6e
http://europepmc.org/articles/PMC5991383
http://europepmc.org/articles/PMC5991383
Autor:
Ae Nim Pae, Ambily Nath Indu Viswanath, Woo-Kyu Park, Eun Joo Roh, Ho Jun Seol, Chong-Ock Lee, Heeyeong Cho, Hyeon Young Kim, Jin-Chul Heo, Heekyoung Yang, Do-Hyun Nam, Ahmed Elkamhawy, Kang Ho Kim
Publikováno v:
European Journal of Medicinal Chemistry. 103:210-222
Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells. Low micromolar IC₅₀ values were exhibited over a panel of three primary GBM patient-derived cell cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09fc74632b29907234c4e0a339130f3
https://doi.org/10.1016/j.ejmech.2015.08.001
https://doi.org/10.1016/j.ejmech.2015.08.001
Autor:
Ho Jin Kwon, Byung Cheol Shin, Yeongseon Byeon, Hat Nim Jeon, Chong Ock Lee, Ye Won Jeon, Hee Dong Han, Sun Hang Cho
Publikováno v:
Acta Biomaterialia. 24:279-285
Drug delivery using thermosensitive liposomes (TSL) has significant potential for tumor drug targeting and can be combined with local hyperthermia to trigger drug release. Although TSL-mediated drug delivery can be effective by itself, we developed d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42073f957ea6de37c34206276a66b9e
https://doi.org/10.1016/j.actbio.2015.06.019
https://doi.org/10.1016/j.actbio.2015.06.019