Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Chong Hwan Chang"'
Autor:
Dianlin Xie, Jing Chen, Celia D’Arienzo, Jodi K. Muckelbauer, Nelly Aranibar, John S. Sack, Jeffrey Tredup, Christine Huang, Charu Chaudhry, Joann Strnad, Percy H. Carter, John S. Tokarski, Adriana Zupa-Fernandez, Joseph B. Santella, Yuval Blat, Gardner Daniel S, James R. Burke, James Lin, David S. Weinstein, Moslin Ryan M, Yifan Zhang, Lihong Cheng, Chong-Hwan Chang, Donna L. Pedicord, Chunjian Liu, J. V. Duncia, Huadong Sun
Publikováno v:
MedChemComm. 8:700-712
As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), and therefore represents an attractive potential target for treating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::552547d736fc9e5ccc4dd8b6c4e38854
https://doi.org/10.1039/c6md00560h
https://doi.org/10.1039/c6md00560h
Publikováno v:
Journal of Clinical Oncology. 38:e16027-e16027
e16027 Background: A metabolism modulatory anticancer durg candidate, OMT-110, has been applied for phase I clinical trial to evaluate the effect of OMT-110 on safety, efficacy, and biomarker in patients with refractory colorectal cancer resistant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ee6e5224821ca7625225aba04d6737
https://doi.org/10.1200/jco.2020.38.15_suppl.e16027
https://doi.org/10.1200/jco.2020.38.15_suppl.e16027
Autor:
Hwan Mook Kim, Jae Jun Sim, Min Hee Park, Chong-Hwan Chang, Hyunju Choi, Young-Kwon Jo, Jong-Moon Park, Hookeun Lee, Keun-Yeong Jeong
Publikováno v:
Nutrition and cancer. 69(4)
Methionine (Met) is involved in one-carbon de novo nucleotide synthesis and is an essential amino acid for cell survival. The impact of lactate calcium salt (CaLa) on the Met metabolism was investigated to evaluate the enhanced antitumor effect of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922dd4ce944841db117fe27851b7995c
https://pubmed.ncbi.nlm.nih.gov/28353361
https://pubmed.ncbi.nlm.nih.gov/28353361
Autor:
Zhong Yang, Jay O. Knipe, Susan B. Roberts, Yong Tu, Paul E. Morin, Ying-Kai Wang, John Wan, Andrew Nickel, Katharine A. Grant-Young, Piyasena Hewawasam, Sam T. Chao, Xiaoliang Zhuo, Bergstrom Carl P, Brett R. Beno, Qi Gao, Dianlin Xie, Chong-Hwan Chang, Dawn D. Parker, Mian Gao, Alicia Regueiro-Ren, Mengping Liu, Umesh Hanumegowda, Richard J. Colonno, Kathy Mosure, Nicholas A. Meanwell, Min Ding, Lenore A. Pelosi, John F. Kadow, Xiaofan Zheng, Steven Sheriff, Voss Stacey A, Alicia Ng, Kenneth S. Santone, Mark R. Witmer, Jung-Hui Sun, Robert G. Gentles, Bender John A, Min Gao, Yi Wang, Jeff Tredup, Daniel M. Camac, Scott W. Martin, Thomas W. Hudyma, Julie A. Lemm, Kap-Sun Yeung, Karen Rigat
Publikováno v:
Journal of Medicinal Chemistry. 57:1855-1879
Described herein are structure-activity relationship studies that resulted in the optimization of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors. Subsequent iterations of analogue design and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef74807d123b8140c1724c36314db30
https://doi.org/10.1021/jm4016894
https://doi.org/10.1021/jm4016894
Autor:
Kwang-Seop Song, Ji-Hyun Park, Hyun-Ju Park, Jooran Na, Suk Ho Lee, Myung Eun Jung, Suk Youn Kang, Jinhwa Lee, Hoseop Yun, Hee Jeong Seo, Chong-Hwan Chang, Sung-Han Lee, Min-ah Kim, Jeongmin Kim, Jakyung Yoo
Publikováno v:
Journal of Medicinal Chemistry. 51:7216-7233
Since the CB1 cannabinoid receptor antagonist 1 (SR141716, rimonabant) was previously reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. In the present study, biarylpyrazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f8e5ee6b2fc8a9e0812562b9ade540
https://doi.org/10.1021/jm800843r
https://doi.org/10.1021/jm800843r
Autor:
Jae-Wook Huh, Young Ho Kim, Betty W. Shen, Barry L. Stoddard, Jean-Man Kim, Paul Clinton Spiegel, Jung-Sik Lee, Chong-Hwan Chang
Publikováno v:
Blood. 111:1240-1247
Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates the assembly of a membrane-bound protease complex on the surface of activated platelets at the site of a vascular injury. Hemophilia A is caused by a variety of mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf39e594f6bb307668d25d6e9faa164e
https://doi.org/10.1182/blood-2007-08-109918
https://doi.org/10.1182/blood-2007-08-109918
Autor:
Steven P. Seitz, Sarah Cox, Pieter F. W. Stouten, Michael D. Boisclair, Stephen L. Brenner, Jay A. Markwalder, Karen A. Rossi, Leonardo Brizuela, Chong-Hwan Chang
Publikováno v:
Journal of Computer-Aided Molecular Design. 19:111-122
Cyclin-dependent kinases (CDKs) play a key role in regulating the cell cycle. The cyclins, their activating agents, and endogenous CDK inhibitors are frequently mutated in human cancers, making CDKs interesting targets for cancer chemotherapy. Our ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3c76fd64d0c81bfd1aa15bb3976390
https://doi.org/10.1007/s10822-005-1778-x
https://doi.org/10.1007/s10822-005-1778-x
Autor:
Angela Smallwood, Jodi K. Muckelbauer, Sarah Cox, C. Anne Higley, Steven P. Seitz, Eddy W. Yue, George L. Trainor, Dimeo Susan, Haiying Chen, Robert H. Grafstrom, Pamela A. Benfield, Jay A. Markwalder, Catherine R. Burton, Chong Hwan Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:343-346
New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eca9874d090f1248663ed651625ea7e
https://doi.org/10.1016/j.bmcl.2003.11.008
https://doi.org/10.1016/j.bmcl.2003.11.008
Autor:
Angela Smallwood, Dimeo Susan, Carrie Benware, Eddy W. Yue, David J. Carini, C. Anne Higley, Lisa M. Sisk, David A. Nugiel, Chong-Hwan Chang, Catherine R. Burton, Diane M. Sharp, Pamela A. Benfield, Jodi K. Muckelbauer, Sarah Cox, Steven P. Seitz, Haiying Chen, John F. Boylan, Robert H. Grafstrom, George L. Trainor
Publikováno v:
Journal of Medicinal Chemistry. 45:5233-5248
The identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and potent compounds. Herein, we report the effects of substitutions at C3 of the indeno[1,2-c]pyrazol-4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::275f3847362bdca5f8cb1694b8f56d26
https://doi.org/10.1021/jm0201722
https://doi.org/10.1021/jm0201722
Autor:
Jie Liu, John F. Boylan, Chong-Hwan Chang, Thais M. Sielecki, Haiying Chen, Robert H. Grafstrom, Angela Smallwood, Catherine R. Burton, Michael D. Boisclair, Steven P. Seitz, Tricia L. Johnson, Sarah Cox, George L. Trainor, Pamela A. Benfield, Jodi K. Muckelbauer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1157-1160
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ad1b9deac14818da4c2f1d31294004
https://doi.org/10.1016/s0960-894x(01)00185-8
https://doi.org/10.1016/s0960-894x(01)00185-8