Výsledky vyhledávání - "Chong Hui Lua"

ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells

Autor: Winston Shim, Chrishan J A Ramachandra, Chong Hui Lua, K P Myu Mai Ja, Anuja Chitre, Ashish Mehta

Publikováno v: Stem Cells. 34:2461-2470

Mechanisms determining intrinsic differentiation bias inherent to human pluripotent stem cells (hPSCs) toward cardiogenic fate remain elusive. We evaluated the interplay between ErbB4 and Epidemal growth factor receptor (EGFR or ErbB1) in determining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b353af96052478876ba895d5687ef7
https://doi.org/10.1002/stem.2420

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Identification of a targeted and testable antiarrhythmic therapy for long-QT syndrome type 2 using a patient-specific cellular model

Autor: Lia Crotti, Massimiliano Gnecchi, Chrishan J A Ramachandra, Anuja Chitre, Ashish Mehta, Chong Hui Lua, Peter J. Schwartz, Philip Wong, Winston Shim, Pritpal Singh, Manuela Mura

Aims Loss-of-function mutations in the hERG gene causes long-QT syndrome type 2 (LQT2), a condition associated with reduced IKr current. Four different mutation classes define the molecular mechanisms impairing hERG. Among them, Class 2 mutations det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752e722a3a747ac8f1a1d89eb9f38386
http://hdl.handle.net/10281/189446

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Acetylated Signal Transducer and Activator of Transcription 3 Functions as Molecular Adaptor Independent of Transcriptional Activity During Human Cardiogenesis

Autor: Chong Hui Lua, Winston Shim, Ashish Mehta, Pritpal Singh, Anuja Chitre, Chrishan J A Ramachandra

Publikováno v: Stem cells (Dayton, Ohio). 35(10)

Activation of signal transducer and activator of transcription 3 (STAT3) is imperative for mammalian development, specifically cardiogenesis. STAT3 phosphorylation and acetylation are key post-translational modifications that regulate its transcripti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fdbcd345f555ac58822d1f8108f643
https://pubmed.ncbi.nlm.nih.gov/28699232

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