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Publikováno v:
Expert Opinion on Therapeutic Patents. 9:1197-1206
S-Adenosyl-L-homocysteine (SAH) hydrolase is a ubiquitous cellular enzyme catalysing the hydrolysis of SAH to adenosine (Ado) and homocysteine (Hcy) in vivo. Due to its central role in regulation o...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a88ad783210453cfbd39bf5bce7ac7
https://doi.org/10.1517/13543776.9.9.1197
https://doi.org/10.1517/13543776.9.9.1197
Autor:
Ronald T. Borchardt, Yang X, Jan Balzarini, Stanislaw F. Wnuk, De Clercq E, Morris J. Robins, Chong-Sheng Yuan
Publikováno v:
Journal of Medicinal Chemistry. 41:3857-3864
Treatment of a protected 9-(5, 6-dideoxy-beta-D-ribo-hex-5-ynofuranosyl)adenine derivative with silver nitrate and N-iodosuccinimide (NIS) and deprotection gave the 6'-iodo acetylenic nucleoside analogue 3c. Halogenation of 3-O-benzoyl-5,6-dideoxy-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3b99c57db44d4702bedef4c8fb06bd
https://doi.org/10.1021/jm980163m
https://doi.org/10.1021/jm980163m
Autor:
Jan Balzarini, Yue Mao, Chong-Sheng Yuan, Ronald T. Borchardt, Morris J. Robins, Graciela Andrei, Stanislaw F. Wnuk, Erik De Clercq
Publikováno v:
Journal of Medicinal Chemistry. 41:3078-3083
Treatment of the 5'-carboxaldehyde derived by Moffatt oxidation of 6-N-benzoyl-2',3'-O-isopropylideneadenosine (1) with the "(bromofluoromethylene)triphenylphosphorane" reagent and deprotection gave 9-(6-bromo-5, 6-dideoxy-6-fluoro-beta-d-ribo-hex-5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e876caf903f9b0b582c0052f2f92bed9
https://doi.org/10.1021/jm9801410
https://doi.org/10.1021/jm9801410
Autor:
Ronald T. Borchardt, Morris J. Robins, Stanislaw F. Wnuk, Vladimir Neschadimenko, Chong-Sheng Yuan, Bong-Oh Ro
Publikováno v:
The Journal of Organic Chemistry. 63:1205-1211
S-Adenosyl-l-homocysteine (AdoHcy) hydrolase is crucial for the maintenance of biomethylation. The usual mechanistic sequence involves oxidation of AdoHcy at C3‘ followed by elimination of l-homocysteine, Michael addition of water, and reduction to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::849793b889314132740b978a0fde6aac
https://doi.org/10.1021/jo971741u
https://doi.org/10.1021/jo971741u
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 17:99-113
Moffatt oxidation of 2′,3′-O-isopropylidenearisteromycin (1a) and treatment of the 5′-carboxaldehyde with [(p-tolylsulfonyl)methylene]triphenylphosphorane gave the homologated vinylsulfone 2. Treatment of 2 with tributylstannane/AIBN gave the (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a19a8a068ffbabfbd4a03493c28095
https://doi.org/10.1080/07328319808005161
https://doi.org/10.1080/07328319808005161
Autor:
Ronald T. Borchardt, De Clercq E, Morris J. Robins, Stanislaw F. Wnuk, Chong-Sheng Yuan, Jan Balzarini
Publikováno v:
Journal of Medicinal Chemistry. 40:1608-1618
Selectively protected adenine nucleosides were converted into 5'-carboxaldehyde analogues by Moffatt oxidation (dimethyl sulfoxide/dicyclohexylcarbodiimide/dichloroacetic acid) or with the Dess-Martin periodinane reagent. Hydrolysis of a 5'-fluoro-5'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4f74cbabd77af9e5772cdbd06ff8b9
https://doi.org/10.1021/jm960828p
https://doi.org/10.1021/jm960828p
Publikováno v:
The Journal of Organic Chemistry. 61:8636-8641
A novel phosphate prodrug system for amines, amino acids, peptides, and peptide mimetics, which utilizes a fast hydroxy amide lactonization of a 3-(2‘-hydroxy-4‘,6‘-dimethylphenyl)-3,3-dimethylpropionic amide system, was developed. Prodrugs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98c0a11730677be840f5cfa0f997536f
https://doi.org/10.1021/jo961477p
https://doi.org/10.1021/jo961477p
Publikováno v:
Archives of Biochemistry and Biophysics. 319:365-371
S -Adenosylhomocysteine (AdoHcy) hydrolase was subjected to limited proteolytic digestion utilizing the proteases trypsin, V8, and papain. Results of the trypsin digest revealed one major susceptible peptide bond between amino acid residues 103 and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8358e1a64aa07003f38a0e42973da9e1
https://doi.org/10.1006/abbi.1995.1306
https://doi.org/10.1006/abbi.1995.1306