Výsledky vyhledávání - "Chondrogenesis/drug effects"

BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner

Autor: Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron

Publikováno v: PLOS ONE, 17(2):e0263430. Public Library of Science
PLoS ONE, Vol 17, Iss 2 (2022)

BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b91411d9a3772f259276cff0fffa8e
https://doi.org/10.1371/journal.pone.0263430

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Impact of Endotoxins in Gelatine Hydrogels on Chondrogenic Differentiation and Inflammatory Cytokine Secretion In Vitro

Autor: Groen, Wilhelmina M.G.A.C., Utomo, Lizette, Castilho, Miguel, Gawlitta, Debby, Malda, Jos, van Weeren, P. René, Levato, Riccardo, Korthagen, Nicoline M., LS Equine Muscoskeletal Biology, Chirurgie, Equine Musculoskeletal Biology, dES RMSC, Dep Clinical Sciences, dES AVR

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8571, p 8571 (2020)
International Journal of Molecular Sciences, 21(22), 1. MDPI AG
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, 21(22):8571, 1-17. Multidisciplinary Digital Publishing Institute (MDPI)

Gelatine methacryloyl (GelMA) hydrogels are widely used in studies aimed at cartilage regeneration. However, the endotoxin content of commercially available GelMAs and gelatines used in these studies is often overlooked, even though endotoxins may in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe464524d89acc2c89a32a6ab7eda176
https://doi.org/10.3390/ijms21228571

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BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner

Autor: Elena Della Bella, Hagen Schmal, Martin J. Stoddart, Mauro Alini, Nikolas J. Kovermann, Eva Johanna Kubosch, Christoph Lischer, Valentina Basoli

Publikováno v: Kovermann, N J, Basoli, V, Della Bella, E, Alini, M, Lischer, C, Schmal, H, Kubosch, E J & Stoddart, M J 2019, ' BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner ', Cells, vol. 8, no. 6, 636 . https://doi.org/10.3390/cells8060636
Cells
Volume 8
Issue 6
Cells, Vol 8, Iss 6, p 636 (2019)

Recent studies highlighting mesenchymal stem cell (MSC) epigenetic memory suggest that a different differentiation medium may be required depending on the tissue of origin. As synovial-derived stem cells (SDSCs) attract interest we aimed to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438fc51a088aa63945b0ef596fe45cb
https://doi.org/10.3390/cells8060636

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Effects of oxygen and culture system on in vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes

Autor: David I. Leavesley, Zee Upton, Travis J. Klein, Karsten Schrobback, Jos Malda, Ross Crawford

Publikováno v: Cell and Tissue Research

Regenerative medicine-based approaches for the repair of damaged cartilage rely on the ability to propagate cells while promoting their chondrogenic potential. Thus, conditions for cell expansion should be optimized through careful environmental cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b7e18ab8633628a54aec120d293251
https://doi.org/10.1007/s00441-011-1193-7

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FGF-2 abolishes the chondrogenic effect of combined BMP-6 and TGF-beta in human adipose derived stem cells

Autor: Christian Gabriel, Florian Hildner, Heinz Redl, Stefan Marlovits, Susanne Wolbank, Sylvia Nürnberger, Anja Peterbauer, Martijn van Griensven

Publikováno v: Journal of biomedical materials research. Part A. 94(3)

In this study, we investigated the influence of transforming growth factor beta 3 (TGF-beta3), bone morphogenetic protein 6 (BMP-6) and basic fibroblast growth factor (FGF-2) on chondrogenesis in adipose derived stem cells (ASC). Cells were isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456cf85fece7af1a4e0ebe82fa60c85b
https://pubmed.ncbi.nlm.nih.gov/20730935

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Implication of C-type natriuretic peptide-3 signaling in glycosaminoglycan synthesis and chondrocyte hypertrophy during TGF-β1 induced chondrogenic differentiation of chicken bone marrow-derived mesenchymal stem cells

Autor: Kocamaz E, Gok D, Cetinkaya A, A. Cevik Tufan

Publikováno v: Europe PubMed Central

This study investigated the involvement of CNP-3, chick homologue for human C-type natriuretic peptide (CNP), in TGF-β1 induced chondrogenic differentiation of chicken bone marrow-derived mesenchymal stem cells (MSCs). Chondrogenic differentiation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2bd4c3271804ac86cd66ea7f9f3f139f
http://europepmc.org/abstract/med/22714108

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