Zobrazeno 1 - 10 of 105 pro vyhledávání: '"Chon-Hwa Tsai Morris"'
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Akademický článek
Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for in vivo screening of candidate therapeutic compounds
Autor: Wei-Chia Tseng, Hannah E. Loeb, Wuhong Pei, Chon-Hwa Tsai-Morris, Lisha Xu, Celine V. Cluzeau, Christopher A. Wassif, Benjamin Feldman, Shawn M. Burgess, William J. Pavan, Forbes D. Porter
Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Niemann-Pick disease type C1 (NPC1) is a rare autosomal recessive lysosomal storage disease primarily caused by mutations in NPC1. NPC1 is characterized by abnormal accumulation of unesterified cholesterol and glycolipids in late endosomes and lysoso
Externí odkaz: https://doaj.org/article/56fcfa5c85bd4a1eb7330a4d2e257a35
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2
Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis
Autor: Raghuveer Kavarthapu, Chon-Hwa Tsai Morris, Rajakumar Anbazhagan, Murugananthkumar Raju, James Pickel, Maria L. Dufau
Publikováno v: Hum Mol Genet
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis specific member of the DEAD-box family of RNA helicases expressed in meiotic and haploid germ cells which plays an essential role in spermatogenesis. There are two species of GRT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663f53cc04c9818e605ceed6ee705915
https://doi.org/10.1093/hmg/ddz079
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3
Detection of precisely edited CRISPR/Cas9 alleles through co-introduced restriction-fragment length polymorphisms
Autor: Ryan K. Dale, James R. Iben, Rosario Y, Kaler Sg, Chang E, Hertafeld S, Yi L, Benjamin Feldman, Chon-Hwa Tsai-Morris, Steve Coon
CRISPR/Cas9 is a powerful tool for producing genomic insertions and deletions (indels) to interrogate gene function. Modified CRISPR/Cas9 protocols can produce targeted genetic changes that are more precise than indels, but founder recovery is less e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caff6b87c4b220ab8d5c8af336967291
https://doi.org/10.1101/2021.04.20.440537
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4
The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish
Autor: Benjamin Feldman, Laura C. Hernández-Ramírez, Giampaolo Trivellin, Harold A. Burgess, Amit Tirosh, Constantine A. Stratakis, Chon Hwa Tsai-Morris, Fabio R. Faucz, Tripti Gupta
Publikováno v: Mol Cell Endocrinol
We recently described X-linked acrogigantism (X-LAG), a condition of early childhood-onset pituitary gigantism associated with microduplications of the GPR101 receptor. The expression of GPR101 in hyperplastic pituitary regions and tumors in X-LAG pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754bb9afaec2d6f7cd3d3b9c33034f32
https://europepmc.org/articles/PMC8771005/
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5
Generation of large genomic deletions to remove zebrafish rca2.1
Autor: Chon-Hwa Tsai-Morris, Margolin, Gennady, R Dale, D Chauss, Kemper, Claudia, B Afzali, Feldman, Benjamin
CD-46 plays a crucial role in the human immune system. We wish to illuminate the role of zebrafish rca2.1, a CD-46 ortholog, in development and health. The sequence and expression of rca2.1 suggests it is a better orthologue to human CD-46 than murin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9148679948cbf2d91b403f2f49bc38cd
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7
Akademický článek
Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis.
Autor: Chon-Hwa Tsai-Morris, Hisashi Sato, Ravi Gutti, Maria L Dufau
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32470 (2012)
Gonadotropin Regulated Testicular RNA Helicase (GRTH/Ddx25) is a testis-specific multifunctional RNA helicase and an essential post-transcriptional regulator of spermatogenesis. GRTH transports relevant mRNAs from nucleus to cytoplasmic sites of meio
Externí odkaz: https://doaj.org/article/8522baf43a994053b0df50e0197808df
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8
SUN-038 Role Of The Satb 1 Gene In Growth Across Species: Findings In A Cohort Of Patients With Short Stature And In A Knockout Zebrafish Model
Autor: Andrea Gutierrez Maria, Laura Hernandez-Ramirez, Giampaolo Trivellin, Fanny Chasseloup, Margarita Dionysiou, Gabriela Vasques, Benjamin Feldman, Chon-Hwa Tsai-Morris, Fabio Faucz, Alexander Jorge, Constantine Stratakis
Publikováno v: Journal of the Endocrine Society
Background: Short stature is a common pediatric disorder, affecting 3% of the population; however, the identification of its cause is limited by its largely variable clinical presentation and genetic heterogeneity. Identification of novel genetic cau
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4311ad9896632352cb4fe8352e04cf6e
http://europepmc.org/articles/PMC6553095
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9
The role of Niemann-Pick type C2 in zebrafish embryonic development
Autor: Chon-Hwa Tsai-Morris, Christopher A. Wassif, Wei-Chia Tseng, Benjamin Feldman, Ana J Johnson Escauriza, Forbes D. Porter, Ryan K. Dale
Publikováno v: Development
Niemann-Pick disease type C (NPC) is a rare, fatal, neurodegenerative lysosomal disease caused by mutations of either NPC1 or NPC2. NPC2 is a soluble lysosomal protein which functions in coordination with NPC1 to efflux cholesterol from the lysosomal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9ea3d5360bd8a8b31c5cde9d3e3a82
https://doi.org/10.1242/dev.194258
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