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pro vyhledávání: '"Chon-Chon Zhao"'
Autor:
Zi-Chao Li, Zhen-Zhen Fan, Ting Tian, Wen-Ting Guo, Chon-Chon Zhao, Hong-Bin Cai, Zhao-Ming Ge
Publikováno v:
Journal of Alzheimer's Disease. :1-10
The connection between diabetes and Alzheimer’s disease (AD) is not fully determined. Hyperphosphorylation of tau protein is mediated by binding and stabilization of truncated p25 with cyclin-dependent kinase-5 (CDK5) in AD. We recently showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179fbad0564425d501bf9aa8606bde7d
https://doi.org/10.3233/jad-200163
https://doi.org/10.3233/jad-200163
Epigenetic Control of CDK5 Promoter Regulates Diabetes-Associated Development of Alzheimer’s Disease
Publikováno v:
Journal of Alzheimer's Disease. 69:743-750
Cyclin-dependent kinase-5 (CDK5) is activated by p35 and then binds to both p35 and its truncated form p25 to promote hyperphosphorylation of tau protein, thereby facilitating the pathological progression of Alzheimer's disease (AD). However, it is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2cfb59fb77506c8040ab3c5a8b0871
https://doi.org/10.3233/jad-190227
https://doi.org/10.3233/jad-190227