Zobrazeno 1 - 10
of 1 872
pro vyhledávání: '"Cholinesterase Inhibitor"'
Autor:
Presenjit, Shubhra Chaturvedi, Akanksha, Deepika Sharma, Ritika Chaudhary, Prachi Verma, Ankita Singh, Kaman Singh
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100759- (2024)
A variety of Tacrine-modified Schiff base analogues were developed via solvent free (green) method and structurally elucidated using 1HNMR, FTIR and UV–Vis analysis. High product yield was obtained from the synthesised molecules, which were prod
Externí odkaz:
https://doaj.org/article/c54b016e0c2444db9be46c3eb0c2aac3
Publikováno v:
Asia Pacific Journal of Medical Toxicology, Vol 12, Iss 4, Pp 165-171 (2023)
Background: Cholinesterase inhibitor (ChEI) insecticide is a common cause of poisoning in developing countries. Toxicity occurs by ingestion, inhalation, or dermal absorption. However, only a few cases of parenteral poisoning have been reported. Inhi
Externí odkaz:
https://doaj.org/article/d826dcf3dc034d6c8cbc961e8a42b971
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Sulphur fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulphur connective hubs. Here, we reported an efficient synthesis and in situ screening method for building a library of sulphon
Externí odkaz:
https://doaj.org/article/bb4c5948d926499ca421b0401a8f881a
Autor:
Hanifa R. Putri, Rhesi Kristiana, I Wayan Mudianta, Edwin Setiawan, Aty Widyawaruyanti, Nitra Nuengchamnong, Nungruthai Suphrom, Suciati Suciati
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 1, Pp 129-136 (2023)
Context: Marine sources such as sponges have shown a significant impact on the drug development from nature. Metabolites isolated from sponges show diversity in terms of structural features and pharmacological properties. Several sponges have been re
Externí odkaz:
https://doaj.org/article/8b0404484d504e8e9d5602ee893598e9
Autor:
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2605-2620 (2022)
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the mo
Externí odkaz:
https://doaj.org/article/1b4b604d4ed2463eadfec515d42a5564
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2099-2111 (2022)
Novel scaffolds are expected to treat Alzheimer’s disease, pyrazole-5-fluorosulfates were found as selective BuChE inhibitors. Compounds K1–K26 were assayed for ChE inhibitory activity, amongst them, compound K3 showed potent BuChE and hBuChE inh
Externí odkaz:
https://doaj.org/article/609e92067768441e9a26d2302814caec
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 505 (2024)
Mefloquine (MQ) is a quinoline-based anti-malarial drug used for chemoprophylaxis or as a treatment in combination with artesunate. Although MQ has clear anti-Plasmodium falciparum properties, it can induce neurotoxicity and undesired neuropsychiatri
Externí odkaz:
https://doaj.org/article/d9f07d5516424c9d994058486121e2ab
Autor:
Varish Ahmad, Ibrahim Alotibi, Anwar A. Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastava
Publikováno v:
Molecules, Vol 29, Iss 3, p 674 (2024)
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ACh). This can cause a variety of cognitive and neurological problems, including Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/bde69f0b5ee8473eaf6194ab13c22636
Akademický článek
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Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionThis study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the p
Externí odkaz:
https://doaj.org/article/c15337b45c694d8e84d3fc8e3ae5630b