Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

Autor: Pablo García-Molina, Alberto Sola-Leyva, Pilar M. Luque-Navarro, Alejandro Laso, Pablo Ríos-Marco, Antonio Ríos, Daniela Lanari, Archimede Torretta, Emilio Parisini, Luisa C. López-Cara, Carmen Marco, María P. Carrasco-Jiménez

Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 426 (2022)

A large number of different types of cancer have been shown to be associated with an abnormal metabolism of phosphatidylcholine (PC), the main component of eukaryotic cell membranes. Indeed, the overexpression of choline kinase α1 (ChoKα1), the enz

Externí odkaz: https://doaj.org/article/52feff0c502f4225b33e95e0ef1959fd

Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors

Autor: Santiago Schiaffino-Ortega, Elena Mariotto, Pilar María Luque-Navarro, María Kimatrai-Salvador, Pablo Rios-Marco, Ramon Hurtado-Guerrero, Carmen Marco, María Paz Carrasco-Jimenez, Giampietro Viola, Luisa Carlota López-Cara

Publikováno v: Pharmaceutics, Vol 13, Iss 9, p 1360 (2021)

Choline kinase inhibitors are an outstanding class of cytotoxic compounds useful for the treatment of different forms of cancer since aberrant choline metabolism is a feature of neoplastic cells. Here, we present the most in-depth structure-activity

Externí odkaz: https://doaj.org/article/bd84aa4beeae4625a0949687619ee237

Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors

Autor: Giampietro Viola, Ramon Hurtado-Guerrero, Carmen Marco, María Kimatrai-Salvador, Pilar María Luque-Navarro, Elena Mariotto, Luisa Carlota Lopez-Cara, Pablo Ríos-Marco, María Paz Carrasco-Jiménez, Santiago Schiaffino-Ortega

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1360, p 1360 (2021)

This research was funded by Convocatoria 2019 Proyectos de I + D + i - RTI Tipo B "Ministerio de Innovacion y Ciencia" grant number PID2019-109294RB-I00 and University of Granada, Cei-BioticProject grant number CEI2013-MP-1.
Choline kinase inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118ae8f8ccd0cb0801e411d802ec4054
http://hdl.handle.net/10481/71080

Mechanism of Action of β -bungarotoxin on Synaptosomal Preparations

Autor: Sen, Indira, Grantham, Patricia A., Cooper, Jack R.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1976 Aug 01. 73(8), 2664-2668.

Externí odkaz: https://www.jstor.org/stable/66024

The Heterogeneous Metabolic Patterns of Ganglia in 68Ga-PSMA, 11C-choline, and 18F-FDG PET/CT in Prostate Cancer Patients

Autor: Yinjie Zhu, Gan Huang, Yiping Shi, Ruohua Chen, Jianjun Liu, Lian Xu, Jian Guo Wu, Yining Wang

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

PurposeStudies have indicated that PSMA-positive ganglia represent a diagnostic pitfall for nuclear medicine physicians. No studies have described choline and FDG uptake in ganglia, which may be a source of misdiagnosis. Herein, we described the perc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4245a27a9456de0cfd1798d9b5a56449
https://www.frontiersin.org/articles/10.3389/fonc.2021.666308/full